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01-07-2009 | Original Paper

Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers

Authors: Cari L. Meinhold, Amy Berrington de Gonzalez, Demetrius Albanes, Stephanie J. Weinstein, Philip R. Taylor, Jarmo Virtamo, Rachael Z. Stolzenberg-Solomon

Published in: Cancer Causes & Control | Issue 5/2009

Abstract

Objectives

A history of type 2 diabetes is one of few consistent risk factors for pancreatic cancer. Potentially modifiable factors related to fasting insulin and glucose concentrations may influence pancreatic cancer risk.

Methods

Multiple linear regression models were used to identify anthropometric, clinical, behavioral, and dietary factors associated with fasting insulin and glucose in a subcohort of non-diabetics in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 366). Hazards ratios (HRs) and 95% confidence intervals (CIs) were calculated among the larger cohort (n = 27,035).

Results

During follow-up (median 16.1 years), 305 participants developed pancreatic cancer. Fasting insulin and/or glucose were positively associated with body mass index (BMI), height, and dietary total and saturated fat and inversely associated with serum high-density lipoprotein cholesterol (HDL) and dietary available carbohydrates, sucrose, and alcohol. Comparing highest to lowest quintiles, total fat (HR = 1.54, 95% CI 1.05–2.25, p-trend = 0.01) and saturated fat (HR = 1.38, 95% CI 0.97–1.98, p-trend = 0.06) were positively associated and available carbohydrates (HR = 0.63, 95% CI 0.44–0.90, p-trend = 0.01), particularly sucrose (HR = 0.62, 95% CI 0.43–0.89, p-trend = 0.09), were inversely associated with risk of pancreatic cancer. BMI, HDL, height, and alcohol were not associated with pancreatic cancer risk.

Conclusion

Dietary fat is associated with higher fasting insulin concentrations and may increase pancreatic cancer risk in smokers.

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Title: Predictors of fasting serum insulin and glucose and the risk of pancreatic cancer in smokers
Authors: Cari L. Meinhold
Amy Berrington de Gonzalez
Demetrius Albanes
Stephanie J. Weinstein
Philip R. Taylor
Jarmo Virtamo
Rachael Z. Stolzenberg-Solomon
Publication date: 01-07-2009
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 5/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9281-z

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