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Cancer Causes & Control
Published in: Cancer Causes & Control 10/2007

01-12-2007 | Original Paper

Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California

Authors: June M. Chan, Furong Wang, Elizabeth A. Holly

Published in: Cancer Causes & Control | Issue 10/2007

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Abstract

Objective

The associations between animal protein or fat and risk of pancreatic cancer have been reported previously with inconsistent results. A population-based case–control study of pancreatic cancer was conducted in the San Francisco Bay Area to examine these associations.

Methods

A semi-quantitative food-frequency questionnaire was administered to 532 cases and 1,701 controls between 1995 and 1999. Odds ratios (OR) and 95% confidence intervals (CI) were computed as estimates of the relative risk of pancreatic cancer.

Results

When comparing highest versus lowest levels of intake in multivariable adjusted models, positive associations were observed for several beef/lamb and individual animal protein items, including beef/lamb as a main dish (OR = 2.2, 95% CI: 1.0–4.5), regular hamburger (OR = 1.7, 95% CI: 1.2–2.4), whole eggs (OR = 1.6, 95% CI: 1.0–2.4), butter (OR = 2.4, 95% CI: 1.6–3.5), and total dairy not including butter (OR = 2.6, 95% CI: 1.8–3.7). Some high-fat/processed-meat products (i.e., sausage, salami, bacon), but not all (i.e., beef, pork, or poultry hot dogs), also were positively associated with risk. An inverse association was noted for greater chicken/turkey consumption (OR = 0.7, 95% CI: 0.5–1.0). The risk comparing the highest versus lowest quartiles for fats and cholesterol consumption were: total fat (OR = 1.6, 95% CI: 1.2–2.1); animal fat (OR = 1.9, 95% CI: 1.4–2.5); saturated fat (OR = 1.9, 95% CI: 1.4–2.6); monounsaturated fat (OR = 1.3, 95% CI: 1.0–1.8); and dietary cholesterol (OR = 1.5, 95% CI: 1.1–2.0, all p-trends ≤ 0.02).

Conclusions

These data provide some evidence that beef or lamb, eggs, dairy, fat, or cholesterol may increase the risk of pancreatic cancer.
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Metadata
Title
Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California
Authors
June M. Chan
Furong Wang
Elizabeth A. Holly
Publication date
01-12-2007
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 10/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-007-9054-0

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