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Cancer Causes & Control
Published in: Cancer Causes & Control 2/2008

01-03-2008 | Original Paper

Spectrum of HIV/AIDS related cancers in India

Authors: Aruna Alahari Dhir, Sheela Sawant, Rajesh P. Dikshit, Purvish Parikh, Shyam Srivastava, Rajan Badwe, Sunil Rajadhyaksha, K. A. Dinshaw

Published in: Cancer Causes & Control | Issue 2/2008

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Abstract

Objective

To study the cancer pattern among HIV positive cancer cases.

Method

The study group included patients registered in the HIV Cancer clinic at the Tata Memorial Hospital (TMH), Mumbai, which is the largest tertiary referral cancer center in India. We used the gender and age-specific proportions of each cancer site of the year 2002 that was recorded in the Hospital Cancer Registry to estimate an expected number of various cancer sites among HIV positive cancer patients during the period 2001–2005. The observed number of site-specific cancer cases was divided by the expected number to obtain proportional incidence ratio (PIR).

Results

No case of Kaposi’s sarcoma was observed. Increased proportion of non- Hodgkin’s lymphoma (NHL) was observed (PIR in males = 17.1, 95%CI 13.33-21.84, females = 10.3, 95%CI 6.10-17.41).In males, PIR was increased for anal cancer (PIR = 10.3, 95%CI 4.30–24.83), Hodgkin’s disease, testicular cancer, colon cancer, and few head and neck cancer sites. Among females, the PIRs for cervical cancer (PIR = 4.1, 95%CI 2.90–5.75), vaginal cancer (PIR = 7.7, 95%CI 2.48–23.85), and anal cancer (PIR = 6.5, 95%CI 0.91–45.88) were increased.

Conclusions

The absence of Kaposi’s sarcoma and increased PIRs for certain non –AIDS defining cancers among HIV infected cancer cases indicates a different spectrum of HIV associated malignancies in this region. The raised PIR for cervical cancer emphasizes the urgent need for screening programs for cervical cancer among HIV infected individuals in India.
Literature
1.
Friedman-Kien AE (1981) Disseminated Kaposi’s sarcoma syndrome in young homosexual men. J Am Acad Dermatol 5(4):468–471PubMed
2.
Centers for disease control: Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome (1987) Morb Mortal Wkly Rep 36:1S–15S
3.
1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults (1992) MMWR Recomm Rep 41:961–962
4.
Goedert JJ, Coté TR, Virgo P et al (1998) Spectrum of AIDS-associated malignant disorders. Lancet 351:1833–1839PubMedCrossRef
5.
UNAIDS/WHO AIDS epidemic update: December 2006
6.
Goedert JJ (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 27(4):390–401PubMed
7.
Dal Maso L, Serraino D, Franceschi S (2001) Epidemiology of AIDS-related tumors in developed and developing countries. Eur J Cancer 37(10):1188–1201PubMedCrossRef
8.
Mbulaiteye SM, Katabira ET, Wabinga H et al (2006) Spectrum of cancers among HIV infected individuals in Africa: The Uganda AIDS –Cancer Registry Match Study. Int J Cancer 118:985–990PubMedCrossRef
9.
Boyle P, Parkin DM (1991) Statistical methods for registries In: Jensen OM, Parkin DM, Maclennan R, Muir CS, Skeet RG (eds), Cancer registration principles and methods. IARC scientific publications, Lyon, pp 126–158
10.
Kumarasamy N, Solomon S, Yesudian P, Sugumar P (1996) First report of Kaposi’s sarcoma in an AIDS patient from Madras, India. Ind J Dermatol 41(1):23–25
11.
Shroff HJ, Dashtawar DR, Deshpande RR, Waigmann HR (1993) AIDS-associated Kaposi’s sarcoma in an Indian female. J Assoc Physicians India 41(4):241–242PubMed
12.
Chandan K, Madnani N, Desai D, Deshpande D (2002) AIDS—associated Kaposi’s sarcoma in a heterosexual male—a case report. Dermatol Online J 8(2):19PubMed
13.
Two year report of population based cancer registries (1999–2000) Incidence and distribution of cancer.National Cancer Registry Programme.ICMR, New Delhi
14.
Boshoff C, Weiss RA (2001) Epidemiology and pathogenesis of Kaposi’s sarcoma associated herpes virus. Philos Trans R Soc Lond B Biol Sci 356(1408):517–534PubMedCrossRef
15.
Ablashi D, Chatlynne L, Cooper H et al (1999) Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa. Br J Cancer 81:893–897PubMedCrossRef
16.
Ayuthaya PI, Katano H, Inagi R et al (2002) The seroprevalence of human herpes virus 8 infection in Thai population. Southeast Asian J Trop Med Public Health 33(2):297–305PubMed
17.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: Human Immunodeficiency Viruses and Human T-Cell Lymphotropic Viruses. Lyon, France 1996, 1–18. IARC Monogr Eval Carcinog Risks Hum 67:1–424
18.
Dal Maso, L, Rezza G, Zambon P et al. (2001) Non-Hodgkin lymphoma among young adults with and without AIDS in Italy. Int J Cancer 93(3):430–435PubMedCrossRef
19.
Grulich AE, Wan X, Law MG, Coates M ,Kaldor JM (1999) Risk of cancer in people with AIDS. AIDS 13(7):839–843PubMedCrossRef
20.
Bower M, Palmary C, Dhillon T (2006) AIDS-related malignancies: Changing epidemiology and the impact of highly active antiretroviral therapy. Curr Opin Infect Dis 19(1):14–19PubMedCrossRef
21.
Wabinga HR, Parkin DM, Warbwire-Mangen F, Nambooze S (2000) Trends in cancer incidence in Kyadondo Country, Uganda, 1960–1997. Br J Cancer 82:1585–1592PubMedCrossRef
22.
Franceschi S, Dal Maso L, Arniani S et al (1998) Risk of cancer other than Kaposi’s sarcoma and non-Hodgkin’s lymphoma in persons with AIDS in Italy. Br J Cancer 78(7):966–970PubMed
23.
Serraino D, Carrieri P, Pradier C et al. (1999) Risk of invasive cervical cancer among women with, or at risk for, HIV infection. Int J Cancer 82(3):334 – 337PubMedCrossRef
24.
Sekirime WK, Gray R (2007) HIV Infection among Uganda Women with Cervical Cancer: a Retrospective Study. Gynecol Obstet Invest 63(4):222–228PubMedCrossRef
25.
La Ruche G, Ramon R, Mensah-Ado I (1998) Squamous intraepithelial lesions of the cervix, invasive cervical carcinoma, and immunosuppression induced by human immunodeficiency virus in Africa. Dyscer-CI Group. Cancer 82(12):2401–2408
26.
Walboomers JM, Jacobs MV, Manos MM et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189(1):12–19PubMedCrossRef
27.
Stier E (2003) Cervical neoplasia and the HIV-infected patient. Hematol Oncol Clin North Am 17 (3):873–887PubMedCrossRef
28.
Palefsky JM, Holly EA (2003) Immunosuppression and co infection with HIV In: J Nat Cancer Inst Monogr 31:41–46
29.
Hutcha S, Parkin DM Trends in the incidence of acquired immunodeficiency syndrome-related malignancies in Thailand.Cancer 101(11):2660–2666
30.
Pantanowitz L, Schlecht HP, Dezube BJ (2006) The growing problem of non-AIDS-defining malignancies in HIV. Curr Opin Oncol 18(5):469–478PubMedCrossRef
31.
Frisch M, Biggar RJ, Goedert JJ (2000) Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 92(18):1500–1510PubMedCrossRef
32.
Petruckevitsh A, Amo JD, Phillips AN, Stephenson JM, Johnson AM, Kock KMD (1999) Risk of cancer in patients with HIV disease. Int J STD AIDS 10(1):38–42CrossRef
33.
Grulich AE, Li Y, McDonald A (2002) Rates of non-AIDS-defining cancers in people with HIV infection before and after AIDS diagnosis. AIDS 16(8):1155–1161PubMedCrossRef
34.
Roland JT Jr, Rothstein SG, Mittal KR, Perky MS (1993) Squamous cell carcinoma in HIV positive individuals under age 45. Laryngoscope 103(5):509–511PubMedCrossRef
35.
Powles T, Powles J, Nelson M et al (2004) Head and neck cancer in patients with human immunodeficiency virus-1 infection :incidence , outcome and association with Epstein –Barr virus. J Laryngol Otol 118(3):207–212PubMedCrossRef
36.
Burgi A, Brodine S, Wegner S et al (2005) Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer 104(7):1505–1511PubMedCrossRef
37.
Moran CA, Tuur S, Angritt P, Reid AH, O’Leary TJ (1992) Epstein-Barr virus in Hodgkin’s disease from patients with human immunodeficiency virus infection. Mod Pathol 5(1):85–88PubMed
38.
Frisch M, Biggar RJ, Engels EA, Goedert JJ (2001) Association of cancer with AIDS-related immunosuppression in adults AIDS-Cancer Match Registry Study Group. JAMA 285(13):1736–1745PubMedCrossRef
Metadata
Title
Spectrum of HIV/AIDS related cancers in India
Authors
Aruna Alahari Dhir
Sheela Sawant
Rajesh P. Dikshit
Purvish Parikh
Shyam Srivastava
Rajan Badwe
Sunil Rajadhyaksha
K. A. Dinshaw
Publication date
01-03-2008
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 2/2008
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-007-9080-y

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