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Breast Cancer Research and Treatment

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01-05-2021 | Breast Cancer | Clinical trial

Performance of dedicated breast positron emission tomography in the detection of small and low-grade breast cancer

Authors: Satoshi Sueoka, Shinsuke Sasada, Norio Masumoto, Akiko Emi, Takayuki Kadoya, Morihito Okada

Published in: Breast Cancer Research and Treatment | Issue 1/2021

Abstract

Purpose

This study compares the sensitivity of dedicated breast positron emission tomography (DbPET) and whole body positron emission tomography (WBPET) in detecting invasive breast cancer based on tumor size and biology. Further, we explored the relationship between maximum standardized uptake value (SUVmax) of DbPET and biological features of the tumor.

Methods

A total of 639 invasive breast cancer lesions subjected to both DbPET and WBPET before surgery, between January 2016 and May 2019, were included in the study. The sensitivity of DbPET and WBPET in detection and the biology of the tumor according to the clinicopathological features were retrospectively evaluated.

Results

The overall sensitivity of DbPET was higher than that of WBPET (91.4% vs. 80.3%, p < 0.001). Subcentimetric tumors were significant (80.9% vs. 54.3%, p < 0.001). Regardless of the nuclear grade, DbPET could detect more lesions than WBPET. The SUVmax was positively correlated with tumor size (R = 0.395, p < 0.001) and the nuclear grade (p < 0.001). Luminal A-like breast cancer had significantly lower SUVmax values than the other subtypes (p < 0.001).

Conclusions

DbPET is superior to WBPET in the detection of subcentimetric, low-grade breast cancers. Further, by using SUVmax, DbPET can distinguish luminal A-like breast cancer from the other subtypes.

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Title: Performance of dedicated breast positron emission tomography in the detection of small and low-grade breast cancer
Authors: Satoshi Sueoka
Shinsuke Sasada
Norio Masumoto
Akiko Emi
Takayuki Kadoya
Morihito Okada
Publication date: 01-05-2021
Publisher: Springer US
Keywords: Breast Cancer
Breast Cancer
Positron Emission Tomography
Published in: Breast Cancer Research and Treatment / Issue 1/2021
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-020-06088-1

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