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01-07-2019 | Obesity | Epidemiology

Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients

Authors: Jung Youn Kim, Dae-Won Lee, Kyung-Hun Lee, Ahrum Min, Han Suk Ryu, Han-Byoel Lee, Hyeong-Gon Moon, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Wonshik Han, In Ae Park, Dong-Young Noh, Seock-Ah Im, Sukil Kim

Published in: Breast Cancer Research and Treatment | Issue 2/2019

Abstract

Purpose

Although controversial, obesity and underweight may have a negative impact on breast cancer outcome. However, the relationship between body mass index (BMI) and breast cancer outcomes according to tumor subtype and menopausal status remains unclear.

Methods

This study investigated the association between BMI and breast cancer outcome in stage I–III breast cancer patients. The relationships were further evaluated according to tumor subtype and menopausal status.

Results

A total of 5919 patients, 3475 (58.7%) hormone receptor (HR)(+) human epidermal growth factor receptor 2 (HER2)(–), 608 (10.3%) HR(+)HER2(+), 621 (10.5%) HR(–)HER2(+), and 1079 (18.2%) HR(–)HER2(–) were included. Underweight and obesity had a negative impact on relapse-free survival but did not affect overall survival. Importantly, the prognostic role of BMI was different according to tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight was associated with poor relapse-free survival and overall survival in pre-menopausal women. In contrast, obesity had negative impact on relapse-free survival and overall survival in HR(+)HER2(–) post-menopausal patients. Underweight may have a negative prognostic role in HR(+)HER2(+) patients. However, BMI did not impact the outcome of HR(–)HER2(+) and HR(–)HER2(–) patients.

Conclusions

The impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population.

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Title: Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients
Authors: Jung Youn Kim
Dae-Won Lee
Kyung-Hun Lee
Ahrum Min
Han Suk Ryu
Han-Byoel Lee
Hyeong-Gon Moon
Tae-Yong Kim
Sae-Won Han
Do-Youn Oh
Wonshik Han
In Ae Park
Dong-Young Noh
Seock-Ah Im
Sukil Kim
Publication date: 01-07-2019
Publisher: Springer US
Keywords: Obesity
Obesity
Breast Cancer
Underweight
Breast Cancer
Underweight
Published in: Breast Cancer Research and Treatment / Issue 2/2019
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-019-05249-1

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