Skip to main content
Top
Published in: Breast Cancer Research and Treatment 1/2017

01-08-2017 | Clinical trial

First international consensus conference on standardization of oncoplastic breast conserving surgery

Authors: Walter P. Weber, Savas D. Soysal, Mahmoud El-Tamer, Virgilio Sacchini, Michael Knauer, Christoph Tausch, Nik Hauser, Andreas Günthert, Yves Harder, Elisabeth A. Kappos, Fabienne Schwab, Florian Fitzal, Peter Dubsky, Vesna Bjelic-Radisic, Roland Reitsamer, Rupert Koller, Jörg Heil, Markus Hahn, Jens-Uwe Blohmer, Jürgen Hoffmann, Christine Solbach, Christoph Heitmann, Bernd Gerber, Martin Haug, Christian Kurzeder

Published in: Breast Cancer Research and Treatment | Issue 1/2017

Login to get access

Abstract

Purpose

To obtain consensus recommendations for the standardization of oncoplastic breast conserving surgery (OPS) from an international panel of experts in breast surgery including delegates from the German, Austrian and Swiss societies of senology.

Methods

A total of 52 questions were addressed by electronic voting. The panel’s recommendations were put into context with current evidence and the report was circled in an iterative open email process until consensus was obtained.

Results

The panelists considered OPS safe and effective for improving aesthetic outcomes and broadening the indication for breast conserving surgery (BCS) towards larger tumors. A slim majority believed that OPS reduces the rate of positive margins; however, there was consensus that OPS is associated with an increased risk of complications compared to conventional BCS. The panel strongly endorsed patient-reported outcomes measurement, and recommended selected scales of the Breast-Q™-Breast Conserving Therapy Module for that purpose. The Clough bi-level classification was recommended for standard use in clinical practice for indicating, planning and performing OPS, and the Hoffmann classification for surgical reports and billing purposes. Mastopexy and reduction mammoplasty were the only two recognized OPS procedure categories supported by a majority of the panel. Finally, the experts unanimously supported the statement that every OPS procedure should be tailored to each individual patient.

Conclusions

When implemented into clinical practice, the panel recommendations may improve safety and effectiveness of OPS. The attendees agreed that there is a need for prospective multicenter studies to optimize patient selection and for standardized criteria to qualify and accredit OPS training centers.
Appendix
Available only for authorised users
Literature
1.
go back to reference Benelli L (1990) A new periareolar mammaplasty: the “round block” technique. Aesthet Plast Surg 14:93–100CrossRef Benelli L (1990) A new periareolar mammaplasty: the “round block” technique. Aesthet Plast Surg 14:93–100CrossRef
2.
go back to reference Clough KB, Nos C, Salmon RJ, Soussaline M, Durand JC (1995) Conservative treatment of breast cancers by mammaplasty and irradiation: a new approach to lower quadrant tumors. Plast Reconstr Surg 96:363–370CrossRefPubMed Clough KB, Nos C, Salmon RJ, Soussaline M, Durand JC (1995) Conservative treatment of breast cancers by mammaplasty and irradiation: a new approach to lower quadrant tumors. Plast Reconstr Surg 96:363–370CrossRefPubMed
3.
go back to reference Galimberti V, Zurrida S, Zanini V, Callegari M, Veronesi P, Catania S, Luini A, Greco M, Grisotti A (1993) Central small size breast cancer: how to overcome the problem of nipple and areola involvement. Eur J Cancer 29A:1093–1096CrossRefPubMed Galimberti V, Zurrida S, Zanini V, Callegari M, Veronesi P, Catania S, Luini A, Greco M, Grisotti A (1993) Central small size breast cancer: how to overcome the problem of nipple and areola involvement. Eur J Cancer 29A:1093–1096CrossRefPubMed
4.
go back to reference Silverstein MJ, Mai T, Savalia N, Vaince F, Guerra L (2014) Oncoplastic breast conservation surgery: the new paradigm. J Surg Oncol 110:82–89CrossRefPubMed Silverstein MJ, Mai T, Savalia N, Vaince F, Guerra L (2014) Oncoplastic breast conservation surgery: the new paradigm. J Surg Oncol 110:82–89CrossRefPubMed
5.
go back to reference Anderson BO, Masetti R, Silverstein MJ (2005) Oncoplastic approaches to partial mastectomy: an overview of volume-displacement techniques. Lancet Oncol 6:145–157CrossRefPubMed Anderson BO, Masetti R, Silverstein MJ (2005) Oncoplastic approaches to partial mastectomy: an overview of volume-displacement techniques. Lancet Oncol 6:145–157CrossRefPubMed
6.
go back to reference Clough KB, Kaufman GJ, Nos C, Buccimazza I, Sarfati IM (2010) Improving breast cancer surgery: a classification and quadrant per quadrant atlas for oncoplastic surgery. Ann Surg Oncol 17:1375–1391CrossRefPubMed Clough KB, Kaufman GJ, Nos C, Buccimazza I, Sarfati IM (2010) Improving breast cancer surgery: a classification and quadrant per quadrant atlas for oncoplastic surgery. Ann Surg Oncol 17:1375–1391CrossRefPubMed
7.
go back to reference Hoffmann J, Wallwiener D (2009) Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients. BMC Cancer 9:108CrossRefPubMedPubMedCentral Hoffmann J, Wallwiener D (2009) Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients. BMC Cancer 9:108CrossRefPubMedPubMedCentral
8.
go back to reference Iwuchukwu OC, Harvey JR, Dordea M, Critchley AC, Drew PJ (2012) The role of oncoplastic therapeutic mammoplasty in breast cancer surgery–a review. Surg Oncol 21:133–141CrossRefPubMed Iwuchukwu OC, Harvey JR, Dordea M, Critchley AC, Drew PJ (2012) The role of oncoplastic therapeutic mammoplasty in breast cancer surgery–a review. Surg Oncol 21:133–141CrossRefPubMed
10.
go back to reference Rainsbury RM (2007) Surgery insight: oncoplastic breast-conserving reconstruction–indications, benefits, choices and outcomes. Nat Clin Pract Oncol 4:657–664CrossRefPubMed Rainsbury RM (2007) Surgery insight: oncoplastic breast-conserving reconstruction–indications, benefits, choices and outcomes. Nat Clin Pract Oncol 4:657–664CrossRefPubMed
11.
go back to reference Rezai M, Kraemer S, Kimmig R, Kern P (2015) Breast conservative surgery and local recurrence. Breast 24(Suppl 2):S100–S107CrossRefPubMed Rezai M, Kraemer S, Kimmig R, Kern P (2015) Breast conservative surgery and local recurrence. Breast 24(Suppl 2):S100–S107CrossRefPubMed
12.
go back to reference Urban C, Lima R, Schunemann E, Spautz C, Rabinovich I, Anselmi K (2011) Oncoplastic principles in breast conserving surgery. Breast 20(Suppl 3):S92–S95CrossRefPubMed Urban C, Lima R, Schunemann E, Spautz C, Rabinovich I, Anselmi K (2011) Oncoplastic principles in breast conserving surgery. Breast 20(Suppl 3):S92–S95CrossRefPubMed
13.
go back to reference Weber WP, Soysal SD, Fulco I, Barandun M, Babst D, Kalbermatten D, Schaefer DJ, Oertli D, Kappos EA, Haug M (2017) Standardization of oncoplastic breast conserving surgery. Eur J Surg Oncol. doi:10.1016/j.ejso.2017.01.006 Weber WP, Soysal SD, Fulco I, Barandun M, Babst D, Kalbermatten D, Schaefer DJ, Oertli D, Kappos EA, Haug M (2017) Standardization of oncoplastic breast conserving surgery. Eur J Surg Oncol. doi:10.​1016/​j.​ejso.​2017.​01.​006
14.
go back to reference Haloua MH, Krekel NM, Winters HA, Rietveld DH, Meijer S, Bloemers FW, van den Tol MP (2013) A systematic review of oncoplastic breast-conserving surgery: current weaknesses and future prospects. Ann Surg 257:609–620CrossRefPubMed Haloua MH, Krekel NM, Winters HA, Rietveld DH, Meijer S, Bloemers FW, van den Tol MP (2013) A systematic review of oncoplastic breast-conserving surgery: current weaknesses and future prospects. Ann Surg 257:609–620CrossRefPubMed
15.
go back to reference Panhofer P, Ferenc V, Schutz M, Gleiss A, Dubsky P, Jakesz R, Gnant M, Fitzal F (2014) Standardization of morbidity assessment in breast cancer surgery using the Clavien Dindo classification. Int J Surg 12:334–339CrossRefPubMed Panhofer P, Ferenc V, Schutz M, Gleiss A, Dubsky P, Jakesz R, Gnant M, Fitzal F (2014) Standardization of morbidity assessment in breast cancer surgery using the Clavien Dindo classification. Int J Surg 12:334–339CrossRefPubMed
16.
go back to reference Carter SA, Lyons GR, Kuerer HM, Bassett RL Jr, Oates S, Thompson A, Caudle AS, Mittendorf EA, Bedrosian I, Lucci A, DeSnyder SM, Babiera G, Yi M, Baumann DP, Clemens MW, Garvey PB, Hunt KK, Hwang RF (2016) Operative and oncologic outcomes in 9861 patients with operable breast cancer: single-institution analysis of breast conservation with oncoplastic reconstruction. Ann Surg Oncol. doi:10.1245/s10434-016-5407-9 PubMedCentral Carter SA, Lyons GR, Kuerer HM, Bassett RL Jr, Oates S, Thompson A, Caudle AS, Mittendorf EA, Bedrosian I, Lucci A, DeSnyder SM, Babiera G, Yi M, Baumann DP, Clemens MW, Garvey PB, Hunt KK, Hwang RF (2016) Operative and oncologic outcomes in 9861 patients with operable breast cancer: single-institution analysis of breast conservation with oncoplastic reconstruction. Ann Surg Oncol. doi:10.​1245/​s10434-016-5407-9 PubMedCentral
17.
go back to reference De La Cruz L, Blankenship SA, Chatterjee A, Geha R, Nocera N, Czerniecki BJ, Tchou J, Fisher CS (2016) Outcomes After oncoplastic breast-conserving surgery in breast cancer patients: a systematic literature review. Ann Surg Oncol 23(10):3247–3258CrossRef De La Cruz L, Blankenship SA, Chatterjee A, Geha R, Nocera N, Czerniecki BJ, Tchou J, Fisher CS (2016) Outcomes After oncoplastic breast-conserving surgery in breast cancer patients: a systematic literature review. Ann Surg Oncol 23(10):3247–3258CrossRef
18.
go back to reference van Maaren MC (2016) de ML, de Bock GH, Jobsen JJ, van DT, Linn SC, Poortmans P, Strobbe LJ, Siesling S: 10 year survival after breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer in the Netherlands: a population-based study. Lancet Oncol 17:1158–1170CrossRefPubMed van Maaren MC (2016) de ML, de Bock GH, Jobsen JJ, van DT, Linn SC, Poortmans P, Strobbe LJ, Siesling S: 10 year survival after breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer in the Netherlands: a population-based study. Lancet Oncol 17:1158–1170CrossRefPubMed
19.
go back to reference Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M (2014) Society of surgical oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Ann Surg Oncol 21:704–716CrossRefPubMed Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M (2014) Society of surgical oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Ann Surg Oncol 21:704–716CrossRefPubMed
20.
go back to reference Santos G, Urban C, Edelweiss MI, Zucca-Matthes G, de Oliveira VM, Arana GH, Iera M, Rietjens M, de Lima RS, Spautz C, Kuroda F, Anselmi K, Capp E (2015) Long-term comparison of aesthetical outcomes after oncoplastic surgery and lumpectomy in breast cancer patients. Ann Surg Oncol 22:2500–2508CrossRefPubMed Santos G, Urban C, Edelweiss MI, Zucca-Matthes G, de Oliveira VM, Arana GH, Iera M, Rietjens M, de Lima RS, Spautz C, Kuroda F, Anselmi K, Capp E (2015) Long-term comparison of aesthetical outcomes after oncoplastic surgery and lumpectomy in breast cancer patients. Ann Surg Oncol 22:2500–2508CrossRefPubMed
21.
go back to reference Losken A, Dugal CS, Styblo TM, Carlson GW (2014) A meta-analysis comparing breast conservation therapy alone to the oncoplastic technique. Ann Plast Surg 72:145–149CrossRefPubMed Losken A, Dugal CS, Styblo TM, Carlson GW (2014) A meta-analysis comparing breast conservation therapy alone to the oncoplastic technique. Ann Plast Surg 72:145–149CrossRefPubMed
22.
go back to reference Down SK, Jha PK, Burger A, Hussien MI (2013) Oncological advantages of oncoplastic breast-conserving surgery in treatment of early breast cancer. Breast J 19:56–63CrossRefPubMed Down SK, Jha PK, Burger A, Hussien MI (2013) Oncological advantages of oncoplastic breast-conserving surgery in treatment of early breast cancer. Breast J 19:56–63CrossRefPubMed
23.
go back to reference Chang EI, Peled AW, Foster RD, Lin C, Zeidler KR, Ewing CA, Alvarado M, Hwang ES, Esserman LJ (2012) Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy. Ann Surg 255:1151–1157CrossRefPubMed Chang EI, Peled AW, Foster RD, Lin C, Zeidler KR, Ewing CA, Alvarado M, Hwang ES, Esserman LJ (2012) Evaluating the feasibility of extended partial mastectomy and immediate reduction mammoplasty reconstruction as an alternative to mastectomy. Ann Surg 255:1151–1157CrossRefPubMed
24.
go back to reference Clough KB, Gouveia PF, Benyahi D, Massey EJ, Russ E, Sarfati I, Nos C (2015) Positive margins after oncoplastic surgery for breast cancer. Ann Surg Oncol 22:4247–4253CrossRefPubMed Clough KB, Gouveia PF, Benyahi D, Massey EJ, Russ E, Sarfati I, Nos C (2015) Positive margins after oncoplastic surgery for breast cancer. Ann Surg Oncol 22:4247–4253CrossRefPubMed
26.
go back to reference Gennari R, Griguolo G, Dieci MV, Guarneri V, Tavaniello B, Sibilio A, Conte P (2016) Fat grafting for breast cancer patients: from basic science to clinical studies. Eur J Surg Oncol 42:1088–1102CrossRefPubMed Gennari R, Griguolo G, Dieci MV, Guarneri V, Tavaniello B, Sibilio A, Conte P (2016) Fat grafting for breast cancer patients: from basic science to clinical studies. Eur J Surg Oncol 42:1088–1102CrossRefPubMed
27.
go back to reference Masia J, Bordoni D, Pons G, Liuzza C, Castagnetti F, Falco G (2015) Oncological safety of breast cancer patients undergoing free-flap reconstruction and lipofilling. Eur J Surg Oncol 41:612–616CrossRefPubMed Masia J, Bordoni D, Pons G, Liuzza C, Castagnetti F, Falco G (2015) Oncological safety of breast cancer patients undergoing free-flap reconstruction and lipofilling. Eur J Surg Oncol 41:612–616CrossRefPubMed
28.
go back to reference Mestak O, Hromadkova V, Fajfrova M, Molitor M, Mestak J (2016) Evaluation of oncological safety of fat grafting after breast-conserving therapy: a prospective study. Ann Surg Oncol 23:776–781CrossRefPubMed Mestak O, Hromadkova V, Fajfrova M, Molitor M, Mestak J (2016) Evaluation of oncological safety of fat grafting after breast-conserving therapy: a prospective study. Ann Surg Oncol 23:776–781CrossRefPubMed
29.
go back to reference Pusic AL, Klassen AF, Scott AM, Klok JA, Cordeiro PG, Cano SJ (2009) Development of a new patient-reported outcome measure for breast surgery: the BREAST-Q. Plast Reconstr Surg 124:345–353CrossRefPubMed Pusic AL, Klassen AF, Scott AM, Klok JA, Cordeiro PG, Cano SJ (2009) Development of a new patient-reported outcome measure for breast surgery: the BREAST-Q. Plast Reconstr Surg 124:345–353CrossRefPubMed
30.
go back to reference Cardoso JS, Cardoso MJ (2007) Towards an intelligent medical system for the aesthetic evaluation of breast cancer conservative treatment. Artif Intell Med 40:115–126CrossRefPubMed Cardoso JS, Cardoso MJ (2007) Towards an intelligent medical system for the aesthetic evaluation of breast cancer conservative treatment. Artif Intell Med 40:115–126CrossRefPubMed
31.
go back to reference Fitzal F, Krois W, Trischler H, Wutzel L, Riedl O, Kuhbelbock U, Wintersteiner B, Cardoso MJ, Dubsky P, Gnant M, Jakesz R, Wild T (2007) The use of a breast symmetry index for objective evaluation of breast cosmesis. Breast 16:429–435CrossRefPubMed Fitzal F, Krois W, Trischler H, Wutzel L, Riedl O, Kuhbelbock U, Wintersteiner B, Cardoso MJ, Dubsky P, Gnant M, Jakesz R, Wild T (2007) The use of a breast symmetry index for objective evaluation of breast cosmesis. Breast 16:429–435CrossRefPubMed
32.
go back to reference Cardoso MJ, Cardoso J, Santos AC, Vrieling C, Christie D, Liljegren G, Azevedo I, Johansen J, Rosa J, Amaral N, Saaristo R, Sacchini V, Barros H, Oliveira MC (2007) Factors determining esthetic outcome after breast cancer conservative treatment. Breast J 13:140–146CrossRefPubMed Cardoso MJ, Cardoso J, Santos AC, Vrieling C, Christie D, Liljegren G, Azevedo I, Johansen J, Rosa J, Amaral N, Saaristo R, Sacchini V, Barros H, Oliveira MC (2007) Factors determining esthetic outcome after breast cancer conservative treatment. Breast J 13:140–146CrossRefPubMed
33.
go back to reference Fitzal F, Mittlboeck M, Trischler H, Krois W, Nehrer G, Deutinger M, Jakesz R, Gnant M (2008) Breast-conserving therapy for centrally located breast cancer. Ann Surg 247:470–476CrossRefPubMed Fitzal F, Mittlboeck M, Trischler H, Krois W, Nehrer G, Deutinger M, Jakesz R, Gnant M (2008) Breast-conserving therapy for centrally located breast cancer. Ann Surg 247:470–476CrossRefPubMed
34.
go back to reference Baildam A, Bishop H, Boland G, Dalglish M, Davies L, Fatah F, Gooch H, Harcourt D, Martin L, Rainsbury D, Rayter Z, Sheppard C, Smith J, Weiler-Mithoff E, Winstanley J, Church J (2007) Oncoplastic breast surgery–a guide to good practice. Eur J Surg Oncol 33(Suppl 1):S1–S23PubMed Baildam A, Bishop H, Boland G, Dalglish M, Davies L, Fatah F, Gooch H, Harcourt D, Martin L, Rainsbury D, Rayter Z, Sheppard C, Smith J, Weiler-Mithoff E, Winstanley J, Church J (2007) Oncoplastic breast surgery–a guide to good practice. Eur J Surg Oncol 33(Suppl 1):S1–S23PubMed
Metadata
Title
First international consensus conference on standardization of oncoplastic breast conserving surgery
Authors
Walter P. Weber
Savas D. Soysal
Mahmoud El-Tamer
Virgilio Sacchini
Michael Knauer
Christoph Tausch
Nik Hauser
Andreas Günthert
Yves Harder
Elisabeth A. Kappos
Fabienne Schwab
Florian Fitzal
Peter Dubsky
Vesna Bjelic-Radisic
Roland Reitsamer
Rupert Koller
Jörg Heil
Markus Hahn
Jens-Uwe Blohmer
Jürgen Hoffmann
Christine Solbach
Christoph Heitmann
Bernd Gerber
Martin Haug
Christian Kurzeder
Publication date
01-08-2017
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2017
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-017-4314-5

Other articles of this Issue 1/2017

Breast Cancer Research and Treatment 1/2017 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine