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Published in: Breast Cancer Research and Treatment 1/2016

01-05-2016 | Review

Potential of breastmilk analysis to inform early events in breast carcinogenesis: rationale and considerations

Authors: Jeanne Murphy, Mark E. Sherman, Eva P. Browne, Ana I. Caballero, Elizabeth C. Punska, Ruth M. Pfeiffer, Hannah P. Yang, Maxwell Lee, Howard Yang, Gretchen L. Gierach, Kathleen F. Arcaro

Published in: Breast Cancer Research and Treatment | Issue 1/2016

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Abstract

This review summarizes methods related to the study of human breastmilk in etiologic and biomarkers research. Despite the importance of reproductive factors in breast carcinogenesis, factors that act early in life are difficult to study because young women rarely require breast imaging or biopsy, and analysis of critical circulating factors (e.g., hormones) is often complicated by the requirement to accurately account for menstrual cycle date. Accordingly, novel approaches are needed to understand how events such as pregnancy, breastfeeding, weaning, and post-weaning breast remodeling influence breast cancer risk. Analysis of breastmilk offers opportunities to understand mechanisms related to carcinogenesis in the breast, and to identify risk markers that may inform efforts to identify high-risk women early in the carcinogenic process. In addition, analysis of breastmilk could have value in early detection or diagnosis of breast cancer. In this article, we describe the potential for using breastmilk to characterize the microenvironment of the lactating breast with the goal of advancing research on risk assessment, prevention, and detection of breast cancer.
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Metadata
Title
Potential of breastmilk analysis to inform early events in breast carcinogenesis: rationale and considerations
Authors
Jeanne Murphy
Mark E. Sherman
Eva P. Browne
Ana I. Caballero
Elizabeth C. Punska
Ruth M. Pfeiffer
Hannah P. Yang
Maxwell Lee
Howard Yang
Gretchen L. Gierach
Kathleen F. Arcaro
Publication date
01-05-2016
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2016
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-016-3796-x

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Breast Cancer Research and Treatment 1/2016 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
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