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01-08-2014 | Preclinical study

RETRACTED ARTICLE: Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression

Authors: Zhongxing Liang, Xuehai Bian, Hyunsuk Shim

Published in: Breast Cancer Research and Treatment | Issue 3/2014

Abstract

Metastasis remains a main cause of mortality from breast cancer and an unresolved issue. The purpose of this study is to investigate the role of miR-302a in the development of breast cancer metastasis mediated by CXCR4, a critical regulator of metastasis, and to identify miR-302a as an effective therapeutic agent for therapy and prevention of breast cancer metastasis. Our studies show that miR-302a expression levels were downregulated in metastatic breast cancer cells and tumor tissues. Additionally, the expression levels of miR-302a were inversely correlated with CXCR4 levels. More promisingly, miR-302a inhibited the invasion and metastasis of breast cancer cells in vitro and in vivo and reduced the expression of CXCR4. Our findings demonstrated that the repression of miR-302a levels contributes to breast cancer metastasis and restoration of miR-302a baseline expression inhibits the invasion and metastasis of breast cancer cells. These data suggest that miR-302a mimics are potential therapeutic agents for breast cancer metastasis.

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Title: RETRACTED ARTICLE: Inhibition of breast cancer metastasis with microRNA-302a by downregulation of CXCR4 expression
Authors: Zhongxing Liang
Xuehai Bian
Hyunsuk Shim
Publication date: 01-08-2014
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2014
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-014-3053-0

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