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Published in: Breast Cancer Research and Treatment 2/2012

01-01-2012 | Epidemiology

Aspirin use and breast cancer risk: a meta-analysis

Authors: Ting Luo, Hua-Mei Yan, Ping He, Yong Luo, Yuan-Fu Yang, Hong Zheng

Published in: Breast Cancer Research and Treatment | Issue 2/2012

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Abstract

Animal and in vitro studies suggest that the use of aspirin may be associated with reduced risk for breast cancer, but results from these studies of the association have been inconsistent. The objective of this meta-analysis was to quantitatively summarize the current evidence for such a relationship. We searched MEDLINE for studies of aspirin use and breast cancer risk that were published in any language, from January 1, 1966, to July 1, 2011. A total of 33 studies (19 cohort studies, 13 case–control studies, and 1 randomized controlled trial [RCT]) that included 1,916,448 subjects were identified. We pooled the relative risks from individual studies using a random-effects model, heterogeneity, and publication bias analyses. In a pooled analysis of all studies, aspirin use was associated with reduced risk for breast cancer (odds ratio [OR] = 0.86, 95% confidence interval [CI] = 0.81, 0.92). In the subgroup analysis by study design, results were similar except for RCT (OR = 0.98, 95% CI = 0.87, 1.09). In conclusion, this meta-analysis indicated that regular use of aspirin may be associated with reduced risk of breast cancer. More RCT were needed to confirm this association in the future.
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Metadata
Title
Aspirin use and breast cancer risk: a meta-analysis
Authors
Ting Luo
Hua-Mei Yan
Ping He
Yong Luo
Yuan-Fu Yang
Hong Zheng
Publication date
01-01-2012
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 2/2012
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-011-1747-0

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