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01-10-2011 | Letter to the Editor

RAD51C germline mutations in Chinese women with familial breast cancer

Authors: Zhiyuan Pang, Lu Yao, Juan Zhang, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Published in: Breast Cancer Research and Treatment | Issue 3/2011

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To the Editor, …

Li WF, Hu Z, Rao NY, Song CG, Zhang B, Cao MZ, Su FX, Wang YS, He PQ, Di GH, Shen KW, Wu J, Lu JS, Luo JM, Liu XY, Zhou J, Wang L, Zhao L, Liu YB, Yuan WT, Yang L, Shen ZZ, Huang W, Shao ZM (2008) The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified. Breast Cancer Res Treat 110(1):99–109PubMedCrossRef

Wu GJ, Sinclair CS, Paape J, Ingle JN, Roche PC, James CD, Couch FJ (2000) 17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes. Cancer Res 60(19):5371–5375PubMed

Dosanjh MK, Collins DW, Fan W, Lennon GG, Albala JS, Shen Z, Schild D (1998) Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Nucleic Acids Res 26(5):1179–1184PubMedCrossRef

French CA, Masson JY, Griffin CS, O’Regan P, West SC, Thacker J (2002) Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem 277(22):19322–19330PubMedCrossRef

Liu Y, Masson JY, Shah R, O’Regan P, West SC (2004) RAD51C is required for Holliday junction processing in mammalian cells. Science 303(5655):243–246PubMedCrossRef

Sharan SK, Kuznetsov SG (2007) Resolving RAD51C function in late stages of homologous recombination. Cell Div 2:15PubMedCrossRef

Smeenk G, de Groot AJ, Romeijn RJ, van Buul PP, Zdzienicka MZ, Mullenders LH, Pastink A, Godthelp BC (2010) Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability. Mutat Res 689(1–2):50–58PubMed

Badie S, Liao C, Thanasoula M, Barber P, Hill MA, Tarsounas M (2009) RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J Cell Biol 185(4):587–600PubMedCrossRef

Vaz F, Hanenberg H, Schuster B, Barker K, Wiek C, Erven V, Neveling K, Endt D, Kesterton I, Autore F, Fraternali F, Freund M, Hartmann L, Grimwade D, Roberts RG, Schaal H, Mohammed S, Rahman N, Schindler D, Mathew CG (2010) Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet 42(5):406–409PubMedCrossRef

10.

Meindl A, Hellebrand H, Wiek C, Erven V, Wappenschmidt B, Niederacher D, Freund M, Lichtner P, Hartmann L, Schaal H, Ramser J, Honisch E, Kubisch C, Wichmann HE, Kast K, Deissler H, Engel C, Muller-Myhsok B, Neveling K, Kiechle M, Mathew CG, Schindler D, Schmutzler RK, Hanenberg H (2010) Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet 42(5):410–414PubMedCrossRef

Title: RAD51C germline mutations in Chinese women with familial breast cancer
Authors: Zhiyuan Pang
Lu Yao
Juan Zhang
Tao Ouyang
Jinfeng Li
Tianfeng Wang
Zhaoqing Fan
Tie Fan
Benyao Lin
Yuntao Xie
Publication date: 01-10-2011
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2011
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-011-1574-3

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