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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 1/2010

01-02-2010 | Review

Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications

Authors: Xuefen Le Bourhis, Rodrigue Romon, Hubert Hondermarck

Published in: Breast Cancer Research and Treatment | Issue 1/2010

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Abstract

Blood vessel formation (neovascularization) in tumors can occur through two mechanisms: angiogenesis and vasculogenesis. Angiogenesis results from proliferation and sprouting of existing blood vessels close to the tumor, while vasculogenesis is believed to arise from recruitment of circulating cells, largely derived from the bone marrow, and de novo clonal formation of blood vessels from these cells. Increasing evidence in animal models indicate that bone marrow-derived endothelial precursor cells (EPC) can contribute to tumor angiogenesis. This review aims to collate existing literature and provide an overview on the current knowledge of EPC involvement in breast cancer angiogenesis. We also discuss recent attempts to use EPC as biomarker and therapeutic target in clinical trials.
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Metadata
Title
Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications
Authors
Xuefen Le Bourhis
Rodrigue Romon
Hubert Hondermarck
Publication date
01-02-2010
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2010
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-009-0686-5

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