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01-10-2009 | Letter to the Editor

A BRCA2 founder mutation and seven novel deleterious BRCA mutations in southern Chinese women with breast and ovarian cancer

Authors: Ava Kwong, L. P. Wong, H. N. Wong, F. B. F. Law, E. K. O. Ng, Y. H. Tang, W. K. Chan, L. S. Ho, K. H. Kwan, M. Poon, T. T. Wong, F. C. S. Leung, S. W. W. Chan, M. W. L. Ying, E. S. K. Ma, J. M. Ford

Published in: Breast Cancer Research and Treatment | Issue 3/2009

Excerpt

Breast cancer incidence in Asia has doubled over the past 10 years and is one of the highest in Hong Kong [1]. Studies in western populations have found differences in breast cancer epidemiology between Asian and Caucasian populations, potentially due to interactions between different lifestyle and genetic characteristics [2‐4]. As the genetic predisposition to breast cancer is increasingly understood, it has been suggested that there are differences in different ethnic populations. To date, only a few investigations on the spectrum of BRCA [5, 6] mutations in Chinese populations have been performed, most of which were performed in single institutions or a small number of medical centers [7‐9]. Some studied only the BRCA1 gene [10, 11] and most did not perform mutational screening using conventional full gene sequencing [12, 13]. …

The Hong Kong Cancer Registry (2005) Fast stats for female breast cancer. http://www3.ha.org.hk/cancereg/

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Title: A BRCA2 founder mutation and seven novel deleterious BRCA mutations in southern Chinese women with breast and ovarian cancer
Authors: Ava Kwong
L. P. Wong
H. N. Wong
F. B. F. Law
E. K. O. Ng
Y. H. Tang
W. K. Chan
L. S. Ho
K. H. Kwan
M. Poon
T. T. Wong
F. C. S. Leung
S. W. W. Chan
M. W. L. Ying
E. S. K. Ma
J. M. Ford
Publication date: 01-10-2009
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-009-0385-2

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