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01-02-2010 | Preclinical Study

The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer

Authors: Marieke E. Straver, Annuska M. Glas, Juliane Hannemann, Jelle Wesseling, Marc J. van de Vijver, Emiel J. Th. Rutgers, Marie-Jeanne T. F. D. Vrancken Peeters, Harm van Tinteren, Laura J. van‘t Veer, Sjoerd Rodenhuis

Published in: Breast Cancer Research and Treatment | Issue 3/2010

Abstract

The 70-gene signature (MammaPrint™) is a prognostic tool used to guide adjuvant treatment decisions. The aim of this study was to assess its value to predict chemosensitivity in the neoadjuvant setting. We obtained the 70-gene profile of stage II–III patients prior to neoadjuvant chemotherapy and classified the prognosis-signatures. Pathological complete remission (pCR) was used to measure chemosensitivity. Among 167 patients, 144 (86%) were having a poor and 23 (14%) a good prognosis-signature. None of the good prognosis-signature patients achieved a pCR (0/23), whereas 29/144 patients (20%) in the poor prognosis-signature group did (P = 0.015). All triple-negative tumors (n = 38) had a poor prognosis-signature. Within the non triple-negative subgroup, the response of the primary tumor remained associated with the classification of the prognosis-signature (P = 0.023). A pCR is unlikely to be achieved in tumors that have a good prognosis-signature. Tumors with a poor prognosis-signature are more sensitive to chemotherapy.

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Title: The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer
Authors: Marieke E. Straver
Annuska M. Glas
Juliane Hannemann
Jelle Wesseling
Marc J. van de Vijver
Emiel J. Th. Rutgers
Marie-Jeanne T. F. D. Vrancken Peeters
Harm van Tinteren
Laura J. van‘t Veer
Sjoerd Rodenhuis
Publication date: 01-02-2010
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2010
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-009-0333-1

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