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01-06-2009 | Review

Acupuncture for treating hot flashes in breast cancer patients: a systematic review

Authors: Myeong Soo Lee, Kun-Hyung Kim, Sun-Mi Choi, Edzard Ernst

Published in: Breast Cancer Research and Treatment | Issue 3/2009

Abstract

The objective of this review was to assess the effectiveness of acupuncture as a treatment option for hot flashes in patients with breast cancer. We searched the literature using 14 databases from their inceptions to August 2008, without language restrictions. We included randomised clinical trials (RCTs) comparing real with sham acupuncture or another active treatment or no treatment. Their methodological quality was assessed using the modified Jadad score. Three RCTs compared the effects of manual acupuncture with sham acupuncture. One RCT showed favourable effects of acupuncture in reducing hot flash frequency, while other two RCTs failed to do so. The meta-analysis show significant effects of acupuncture compared with sham acupuncture (n = 189, weight mean difference, 3.09, 95% confidence intervals −0.04 to 6.23, P = 0.05) but marked heterogeneity was observed in this model (χ ² = 8.32, P = 0.02, I ² = 76%). One RCT compared the effects of electroacupuncture (EA) with hormone replacement therapy. Hormone therapy was more effective than EA. Another RCT compared acupuncture with venlafaxine and reported no significant intergroup difference. A further RCT compared acupuncture with applied relaxation and failed to show a significant intergroup difference. In conclusion, the evidence is not convincing to suggest acupuncture is an effective treatment of hot flash in patients with breast cancer. Further research is required to investigate whether there are specific effects of acupuncture for treating hot flash in patients with breast cancer.

Stearns V, Loprinzi CL (2003) New therapeutic approaches for hot flashes in women. J Support Oncol 1:11–21 discussion 14–15, 19–21PubMed

Antoine C, Vandromme J, Fastrez M, Carly B, Liebens F, Rozenberg S (2008) A survey among breast cancer survivors: treatment of the climacteric after breast cancer. Climacteric 11:322–328. doi:10.1080/13697130802244422 PubMedCrossRef

Daley A, MacArthur C, McManus R et al (2006) Factors associated with the use of complementary medicine and non-pharmacological interventions in symptomatic menopausal women. Climacteric 9:336–346. doi:10.1080/13697130600864074 PubMedCrossRef

Kessel B, Kronenberg F (2004) The role of complementary and alternative medicine in management of menopausal symptoms. Endocrinol Metab Clin North Am 33:717–739. doi:10.1016/j.ecl.2004.07.004 PubMedCrossRef

Kronenberg F, Fugh-Berman A (2002) Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 137:805–813PubMed

Newton KM, Buist DS, Keenan NL, Anderson LA, LaCroix AZ (2002) Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet Gynecol 100:18–25. doi:10.1016/S0029-7844(02)02005-7 PubMedCrossRef

Arai YC, Ushida T, Osuga T et al (2008) The effect of acupressure at the extra 1 point on subjective and autonomic responses to needle insertion. Anesth Analg 107:661–664PubMedCrossRef

Backer M, Grossman P, Schneider J et al (2008) Acupuncture in migraine: investigation of autonomic effects. Clin J Pain 24:106–115PubMedCrossRef

Uchida S, Hotta H (2008) Acupuncture affects regional blood flow in various organs. Evid Based Complement Altern Med 5:145–151. doi:10.1093/ecam/nem051 CrossRef

10.

Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12. doi:10.1016/0197-2456(95)00134-4 PubMedCrossRef

11.

White AR, Ernst E (1999) A systematic review of randomized controlled trials of acupuncture for neck pain. Rheumatology 38:143–147. doi:10.1093/rheumatology/38.2.143 PubMedCrossRef

12.

Follmann D, Elliott P, Suh I, Cutler J (1992) Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 45:769–773. doi:10.1016/0895-4356(92)90054-Q PubMedCrossRef

13.

Deng G, Vickers A, Yeung S, Cassileth B (2007) Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients. J Clin Oncol 25:5584–5590. doi:10.1200/JCO.2007.12.0774 PubMedCrossRef

14.

Davies FM (2001) The effect of acupuncture treatment on the incidence and severity of hot flushes experienced by women following treatment for breast cancer: a comparison of traditional and minimal acupuncture. Eur J Cancer 37:S438–S438. doi:10.1016/S0959-8049(01)82079-7 CrossRef

15.

Hervik J, Mjåland O (2008) Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial. Breast Cancer Res Treat. doi:10.1007/s10549-008-0210-3

16.

Frisk J, Carlhall S, Kallstrom AC, Lindh-Astrand L, Malmstrom A, Hammar M (2008) Long-term follow-up of acupuncture and hormone therapy on hot flushes in women with breast cancer: a prospective, randomized, controlled multicenter trial. Climacteric 11:166–174. doi:10.1080/13697130801958709 PubMedCrossRef

17.

Walker EM, Rodriguez AI, Kohn B, Pegg J, Bell RM, Levine RA (2008) Acupuncture for the treatment of vasomotor symptoms in breast cancer patients receiving hormone suppression treatment. Int J Radiat Oncol Biol Phys 72:S103–S103. doi:10.1016/j.ijrobp.2008.06.1000

18.

Nedstrand E, Wijma K, Wyon Y, Hammar M (2005) Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study. Climacteric 8:243–250. doi:10.1080/13697130500118050 PubMedCrossRef

19.

Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273:408–412. doi:10.1001/jama.273.5.408 PubMedCrossRef

20.

Day SJ, Altman DG (2000) Statistics notes: blinding in clinical trials and other studies. BMJ 321:504. doi:10.1136/bmj.321.7259.504 PubMedCrossRef

21.

Ernst E, Pittler MH (1997) Alternative therapy bias. Nature 385:480. doi:10.1038/385480c0 PubMedCrossRef

22.

Pittler MH, Abbot NC, Harkness EF, Ernst E (2000) Location bias in controlled clinical trials of complementary/alternative therapies. J Clin Epidemiol 53:485–489. doi:10.1016/S0895-4356(99)00220-6 PubMedCrossRef

Title: Acupuncture for treating hot flashes in breast cancer patients: a systematic review
Authors: Myeong Soo Lee
Kun-Hyung Kim
Sun-Mi Choi
Edzard Ernst
Publication date: 01-06-2009
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-008-0230-z

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