Skip to main content
Top
Published in: Breast Cancer Research and Treatment 1/2009

01-05-2009 | Review

An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature

Authors: Sumanta Kumar Pal, Kathleen Blazer, Jeffrey Weitzel, George Somlo

Published in: Breast Cancer Research and Treatment | Issue 1/2009

Login to get access

Abstract

The possibility of an association between primary hyperparathyroidism and breast cancer has been postulated. We report here a sibship with three premenopausal breast cancers and hyperparathyroidism, and no detectable BRCA or MEN1 gene mutations. We explore genetic and molecular rationales for an association between these metabolic and neoplastic processes.
Literature
2.
3.
go back to reference Heath H, Hodgson SF, Kennedy MA (1980) Primary hyperparathyroidism incidence, morbidity and potential economic impact in the community. N Engl J Med 302(4):189–193PubMed Heath H, Hodgson SF, Kennedy MA (1980) Primary hyperparathyroidism incidence, morbidity and potential economic impact in the community. N Engl J Med 302(4):189–193PubMed
6.
go back to reference Corte MD, Tamargo F, Alvarez A et al (2006) Cytosolic levels of TFF1/pS2 in breast cancer: their relationship to clinical-pathological parameters and their prognostic significance. Breast Cancer Res Treat 96(1):63–72. doi:10.1007/s10549-005-9041-7 PubMedCrossRef Corte MD, Tamargo F, Alvarez A et al (2006) Cytosolic levels of TFF1/pS2 in breast cancer: their relationship to clinical-pathological parameters and their prognostic significance. Breast Cancer Res Treat 96(1):63–72. doi:10.​1007/​s10549-005-9041-7 PubMedCrossRef
11.
go back to reference Nilsson IL, Zedenius J, Yin L et al (2007) The association between primary hyperparathyroidism and malignancy: nationwide cohort on cancer incidence after parathyroidectomy. Endocr Relat Cancer 14(1):135–140. doi:10.1677/erc.1.01261 PubMedCrossRef Nilsson IL, Zedenius J, Yin L et al (2007) The association between primary hyperparathyroidism and malignancy: nationwide cohort on cancer incidence after parathyroidectomy. Endocr Relat Cancer 14(1):135–140. doi:10.​1677/​erc.​1.​01261 PubMedCrossRef
12.
go back to reference Fierabracci P, Pinchera A, Miccoli P et al (2001) Increased prevalence of primary hyperparathyroidism in treated breast cancer. J Endocrinol Invest 24(5):315–320PubMed Fierabracci P, Pinchera A, Miccoli P et al (2001) Increased prevalence of primary hyperparathyroidism in treated breast cancer. J Endocrinol Invest 24(5):315–320PubMed
13.
go back to reference Axelrod DM, Bockman RS, Wong GY et al (1987) Distinguishing features of primary hyperparathyroidism in patients with breast cancer. Cancer 60(7):1620–1624. doi:10.1002/1097-0142(19871001)60:7≤1620::AID-CNCR2820600733≥3.0.CO;2-3PubMedCrossRef Axelrod DM, Bockman RS, Wong GY et al (1987) Distinguishing features of primary hyperparathyroidism in patients with breast cancer. Cancer 60(7):1620–1624. doi:10.1002/1097-0142(19871001)60:7≤1620::AID-CNCR2820600733≥3.0.CO;2-3PubMedCrossRef
14.
go back to reference Kristensen B, Mouridsen HT, Holmegaard SN et al (1989) Amelioration of postmenopausal primary hyperparathyroidism during adjuvant tamoxifen for breast cancer. Cancer 64(9):1965–1967. doi:10.1002/1097-0142(19891101)64:9≤1965::AID-CNCR2820640933≥3.0.CO;2-GPubMedCrossRef Kristensen B, Mouridsen HT, Holmegaard SN et al (1989) Amelioration of postmenopausal primary hyperparathyroidism during adjuvant tamoxifen for breast cancer. Cancer 64(9):1965–1967. doi:10.1002/1097-0142(19891101)64:9≤1965::AID-CNCR2820640933≥3.0.CO;2-GPubMedCrossRef
16.
go back to reference Birch MA, Carron JA, Scott M et al (1995) Parathryoid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines. Br J Cancer 721:90–95 Birch MA, Carron JA, Scott M et al (1995) Parathryoid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines. Br J Cancer 721:90–95
17.
go back to reference Hoey RP, Sanderson C, Iddon J et al (2003) The parathyroid-hormone related protein receptor is expressed in bone metastases and promotes autocrine proliferation of breast cancer cells. Br J Cancer 884:567–573. doi:10.1038/sj.bjc.6600757 CrossRef Hoey RP, Sanderson C, Iddon J et al (2003) The parathyroid-hormone related protein receptor is expressed in bone metastases and promotes autocrine proliferation of breast cancer cells. Br J Cancer 884:567–573. doi:10.​1038/​sj.​bjc.​6600757 CrossRef
18.
go back to reference Bianchi GV, Loibl S, Zamagni C et al (2007) Phase II multicenter trial of sorafenib in the treatment of patients with metastatic breast cancer. Proc Amer Soc Clin Oncol Breast Cancer Symposium 2007 (Abstract #164) Bianchi GV, Loibl S, Zamagni C et al (2007) Phase II multicenter trial of sorafenib in the treatment of patients with metastatic breast cancer. Proc Amer Soc Clin Oncol Breast Cancer Symposium 2007 (Abstract #164)
20.
go back to reference Nishioka C, Ikeoze T, Yang J et al (2007) Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. Leuk Res (epub ahead of print.) Nishioka C, Ikeoze T, Yang J et al (2007) Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene. Leuk Res (epub ahead of print.)
21.
Metadata
Title
An association between invasive breast cancer and familial idiopathic hyperparathyroidism: a case series and review of the literature
Authors
Sumanta Kumar Pal
Kathleen Blazer
Jeffrey Weitzel
George Somlo
Publication date
01-05-2009
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-008-0056-8

Other articles of this Issue 1/2009

Breast Cancer Research and Treatment 1/2009 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine