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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 3/2009

01-04-2009 | Epidemiology

Mutations of the MYH gene do not substantially contribute to the risk of breast cancer

Authors: Mario E. Beiner, William W. Zhang, Shiyu Zhang, Steven Gallinger, Ping Sun, Steven A. Narod

Published in: Breast Cancer Research and Treatment | Issue 3/2009

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Abstract

Purpose To explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer. Methods 691 breast cancer patients and 812 healthy controls were genotyped for the MYH Y165C and G382D mutations. The frequencies of heterozygotes, homozygotes and compound heterozygotes were compared for the two groups. Results Four (0.6%) of 691 breast cancer cases carried a MYH Y165C mutant allele, compared to five (0.6%) of the controls (OR 1.1, 95%CI 0.29–4.0, P = 0.9). Eight (1.2%) cases carried a MYH G382D mutant allele, compared to eight (1.0%) of the controls (OR 1.2, 95%CI 0.44–3.3, P = 0.7). No case or control was homozygous for the variant and none were compound heterozygotes. Conclusion Carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer.
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Metadata
Title
Mutations of the MYH gene do not substantially contribute to the risk of breast cancer
Authors
Mario E. Beiner
William W. Zhang
Shiyu Zhang
Steven Gallinger
Ping Sun
Steven A. Narod
Publication date
01-04-2009
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 3/2009
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-008-0042-1

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