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Breast Cancer Research and Treatment

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01-03-2008 | Epidemiology

Alcohol intake and breast cancer risk among young women

Authors: Paula Berstad, Huiyan Ma, Leslie Bernstein, Giske Ursin

Published in: Breast Cancer Research and Treatment | Issue 1/2008

Abstract

Introduction

Alcohol intake has been consistently associated with breast cancer risk, but the importance of timing of intake and the impact of beverage type are unclear.

Methods

We evaluated whether early, lifetime or recent alcohol intake was associated with breast cancer risk, and whether risk varied by type of alcoholic drinks in 1,728 newly diagnosed population-based breast cancer patients and 435 control subjects aged 20–49 years. We used multivariable logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) as measures of the relative risk of breast cancer associated with intake of alcoholic drinks.

Results

Intake of alcoholic drinks during the recent five year period before the breast cancer diagnosis was associated with increased breast cancer risk (P _trend = 0.04). Intake of two or more alcoholic drinks per day during this five year period was associated with an 82% increase in breast cancer risk relative to never drinkers (OR = 1.82, 95% CI = 1.01–3.28). No risk increase was observed for alcohol intake at ages 15–20 years or for lifetime alcohol intake. Risk did not vary by type of alcohol consumed.

Conclusions

Our results suggest that recent alcohol consumption may be associated with increased breast cancer risk in young women.

Hamajima N, Hirose K, Tajima K, Rohan T, Calle EE, Heath CW, Jr. Coates RJ, Liff JM, Talamini R, Chantarakul N et al (2002) Alcohol, tobacco and breast cancer–collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 87(11):1234–1245PubMedCrossRef

Key J, Hodgson S, Omar RZ, Jensen TK, Thompson SG, Boobis AR, Davies DS, Elliott P (2006) Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues. Cancer Causes Control 17(6):759–770PubMedCrossRef

Holmberg L, Baron JA, Byers T, Wolk A, Ohlander EM, Zack M, Adami HO (1995) Alcohol intake and breast cancer risk: effect of exposure from 15 years of age. Cancer Epidemiol Biomarkers Prev 4(8):843–847PubMed

Longnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Clapp RW, Bogdan GF, Baron J, MacMahon B, Willett WC (1995) Risk of breast cancer in relation to lifetime alcohol consumption. J Natl Cancer Inst 87(12):923–929PubMedCrossRef

McDonald JA, Mandel MG, Marchbanks PA, Folger SG, Daling JR, Ursin G, Simon MS, Bernstein L, Strom BL, Norman SA et al (2004) Alcohol exposure and breast cancer: results of the women’s contraceptive and reproductive experiences study. Cancer Epidemiol Biomarkers Prev 13(12):2106–2116PubMed

Van’t Veer P, Kok FJ, Hermus RJ, Sturmans F (1989) Alcohol dose, frequency and age at first exposure in relation to the risk of breast cancer. Int J Epidemiol 18(3):511–517PubMedCrossRef

Okasha M, McCarron P, Gunnell D, Smith GD (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat 78(2):223–276PubMedCrossRef

Horn-Ross PL, Canchola AJ, West DW, Stewart SL, Bernstein L, Deapen D, Pinder R, Ross RK, Anton-Culver H, Peel D et al (2004) Patterns of alcohol consumption and breast cancer risk in the California Teachers Study cohort. Cancer Epidemiol Biomarkers Prev 13(3):405–411PubMed

Tjonneland A, Christensen J, Thomsen BL, Olsen A, Stripp C, Overvad K, Olsen JH (2004) Lifetime alcohol consumption and postmenopausal breast cancer rate in Denmark: a prospective cohort study. J Nutr 134(1):173–178PubMed

10.

Terry MB, Zhang FF, Kabat G, Britton JA, Teitelbaum SL, Neugut AI, Gammon MD (2006) Lifetime alcohol intake and breast cancer risk. Ann Epidemiol 16(3):230–240PubMedCrossRef

11.

Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC (1999) Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25–42 years of age. Cancer Epidemiol Biomarkers Prev 8(11):1017–1021PubMed

12.

Kinney AY, Millikan RC, Lin YH, Moorman PG, Newman B (2000) Alcohol consumption and breast cancer among black and white women in North Carolina (United States). Cancer Causes Control 11(4):345–357PubMedCrossRef

13.

Ma H, Bernstein L, Ross RK, Ursin G (2006) Hormone-related risk factors for breast cancer in women under age 50 years by estrogen and progesterone receptor status: results from a case-control and a case-case comparison. Breast Cancer Res 8(4):R39PubMedCrossRef

14.

Ursin G, Peters RK, Henderson BE, d’Ablaing G, III Monroe KR, Pike MC (1994) Oral contraceptive use and adenocarcinoma of cervix. Lancet 344(8934):1390–1394PubMedCrossRef

15.

Marchbanks PA, McDonald JA, Wilson HG, Burnett NM, Daling JR, Bernstein L, Malone KE, Strom BL, Norman SA, Weiss LK et al (2002) The NICHD women’s contraceptive and reproductive experiences study: methods and operational results. Ann Epidemiol 12(4):213–221PubMedCrossRef

16.

Rothman KJ, Greenland S (1998) Modern Epidemiology. 2nd edn. Lippincott Williams & Wilkins, Philadelphia, PA, USA

17.

Swanson CA, Coates RJ, Malone KE, Gammon MD, Schoenberg JB, Brogan DJ, McAdams M, Potischman N, Hoover RN, Brinton LA (1997) Alcohol consumption and breast cancer risk among women under age 45 years. Epidemiology 8(3):231–237PubMedCrossRef

18.

Harvey EB, Schairer C, Brinton LA, Hoover RN, Fraumeni JF Jr. (1987) Alcohol consumption and breast cancer. J Natl Cancer Inst 78(4):657–661PubMed

19.

Männistö S, Virtanen M, Kataja V, Uusitupa M, Pietinen P (2000) Lifetime alcohol consumption and breast cancer: a case-control study in Finland. Public Health Nutr 3(1):11–18PubMedCrossRef

20.

Dees WL, Srivastava VK, Hiney JK (2001) Alcohol and female puberty: the role of intraovarian systems. Alcohol Res Health 25(4):271–275PubMed

21.

Petri AL, Tjonneland A, Gamborg M, Johansen D, Hoidrup S, Sorensen TI, Gronbaek M (2004) Alcohol intake, type of beverage, and risk of breast cancer in pre- and postmenopausal women. Alcohol Clin Exp Res 28(7):1084–1090PubMedCrossRef

22.

Mattisson I, Wirfalt E, Wallstrom P, Gullberg B, Olsson H, Berglund G (2004) High fat and alcohol intakes are risk factors of postmenopausal breast cancer: a prospective study from the Malmo diet and cancer cohort. Int J Cancer 110(4):589–597PubMedCrossRef

23.

Halvorsen BL, Carlsen MH, Phillips KM, Bohn SK, Holte K, Jacobs DR, Jr. Blomhoff R (2006) Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr 84(1):95–135PubMed

24.

Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La VC (2005) Resveratrol and breast cancer risk. Eur J Cancer Prev 14(2):139–142PubMedCrossRef

25.

Klatsky AL, Armstrong MA, Kipp H (1990) Correlates of alcoholic beverage preference: traits of persons who choose wine, liquor or beer. Br J Addict 85(10):1279–1289PubMedCrossRef

26.

Rinaldi S, Peeters PH, Bezemer ID, Dossus L, Biessy C, Sacerdote C, Berrino F, Panico S, Palli D, Tumino R et al (2006) Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nutrition. Cancer Causes Control 17(8):1033–1043PubMedCrossRef

27.

Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PH, Biessy C, Dossus L, Lukanova A, Bingham S, Khaw KT et al (2005) Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 12(4):1071–1082PubMedCrossRef

28.

Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H et al (2005) Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 97(10):755–765PubMedCrossRef

29.

Stoll BA (1999) Alcohol intake and late-stage promotion of breast cancer. Eur J Cancer 35(12):1653–1658PubMedCrossRef

30.

Vachon CM, Kushi LH, Cerhan JR, Kuni CC, Sellers TA (2000) Association of diet and mammographic breast density in the Minnesota breast cancer family cohort. Cancer Epidemiol Biomarkers Prev 9(2):151–160PubMed

31.

Tjonneland A, Thomsen BL, Stripp C, Christensen J, Overvad K, Mellemkaer L, Gronbaek M, Olsen JH (2003) Alcohol intake, drinking patterns and risk of postmenopausal breast cancer in Denmark: a prospective cohort study. Cancer Causes Control 14(3):277–284PubMedCrossRef

32.

Willett WC (2001) Diet and breast cancer. J Intern Med 249(5):395–411PubMedCrossRef

33.

Larsson SC, Giovannucci E, Wolk A (2007) Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 99(1):64–76PubMedCrossRef

Title: Alcohol intake and breast cancer risk among young women
Authors: Paula Berstad
Huiyan Ma
Leslie Bernstein
Giske Ursin
Publication date: 01-03-2008
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 1/2008
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9578-8

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