Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Brain Topography
Published in: Brain Topography 3/2016

01-05-2016 | Original Paper

Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder

Authors: Youxue Zhang, Bing Xie, Heng Chen, Meiling Li, Feng Liu, Huafu Chen

Published in: Brain Topography | Issue 3/2016

Login to get access

Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs in individuals who have experienced life-threatening mental traumas. Previous neuroimaging studies have indicated that the pathology of PTSD may be associated with the abnormal functional integration among brain regions. In the current study, we used functional connectivity density (FCD) mapping, a novel voxel-wise data-driven approach based on graph theory, to explore aberrant FC through the resting-state functional magnetic resonance imaging of the PTSD. We calculated both short- and long-range FCD in PTSD patients and healthy controls (HCs). Compared with HCs, PTSD patients showed significantly increased long-range FCD in the left dorsolateral prefrontal cortex (DLPFC), but no abnormal short-range FCD was found in PTSD. Furthermore, seed-based FC analysis of the left DLPFC showed increased connectivity in the left superior parietal lobe and visual cortex of PTSD patients. The results suggested that PTSD patients experienced a disruption of intrinsic long-range functional connections in the fronto-parietal network and visual cortex, which are associated with attention control and visual information processing.
Appendix
Available only for authorised users
Literature
Barcelo F, Suwazono S, Knight RT (2000) Prefrontal modulation of visual processing in humans. Nat Neurosci 3:399–403CrossRefPubMed
Barkhof F, Haller S, Rombouts SA (2014) Resting-state functional MR imaging: a new window to the brain. Radiology 272:29–49CrossRefPubMed
Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM (1995) The development of a clinician-administered PTSD scale. J Trauma Stress 8:75–90CrossRefPubMed
Blatt GJ, Pandya DN, Rosene DL (2003) Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study. J Comp Neurol 466:161–179CrossRefPubMed
Bradley R, Greene J, Russ E, Dutra L, Westen D (2005) A multidimensional meta-analysis of psychotherapy for PTSD. Am J Psychiatry 162:214–227CrossRefPubMed
Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3:201–215CrossRefPubMed
Egner T, Hirsch J (2005) The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage 24:539–547CrossRefPubMed
Fani N, Jovanovic T, Ely TD, Bradley B, Gutman D, Tone EB, Ressler KJ (2012) Neural correlates of attention bias to threat in post-traumatic stress disorder. Biol Psychol 90:134–142CrossRefPubMedPubMedCentral
Francati V, Vermetten E, Bremner J (2007) Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings. Depress Anxiety 24:202–218CrossRefPubMedPubMedCentral
Friston KJ, Williams S, Howard R, Frackowiak RS, Turner R (1996) Movement-related effects in fMRI time-series. Magn Reson Med 35:346–355CrossRefPubMed
Gazzaley A, D’Esposito M (2007) Unifying prefrontal cortex function: executive control, neural networks, and top-down modulation. The human frontal lobes: Functions and disorders. Guilford Press, New York, NY, pp 187–206
Guo W-B, Liu F, Xue Z-M, Yu Y, Ma C-Q, Tan C-L, Sun X-L, Chen J-D, Liu Z-N, Xiao C-Q (2011) Abnormal neural activities in first-episode, treatment-naive, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study. J Affect Disord 135:326–331CrossRefPubMed
Guo W, Liu F, Xue Z, Gao K, Liu Z, Xiao C, Chen H, Zhao J (2013) Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression. Prog Neuropsychopharmacol Biol Psychiatry 44:51–57CrossRefPubMed
Hopfinger JB, Buonocore MH, Mangun GR (2000) The neural mechanisms of top-down attentional control. Nat Neurosci 3:284–291CrossRefPubMed
Kastner S, Ungerleider LG (2000) Mechanisms of visual attention in the human cortex. Annu Rev Neurosci 23:315–341CrossRefPubMed
Lanius R, Bluhm R, Coupland N, Hegadoren K, Rowe B, Theberge J, Neufeld R, Williamson P, Brimson M (2010) Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects. Acta Psychiatr Scand 121:33–40CrossRefPubMed
Liu F, Hu M, Wang S, Guo W, Zhao J, Li J, Xun G, Long Z, Zhang J, Wang Y, Zeng L, Gao Q, Wooderson SC, Chen J, Chen H (2012) Abnormal regional spontaneous neural activity in first-episode, treatment-naive patients with late-life depression: a resting-state fMRI study. Prog Neuropsychopharmacol Biol Psychiatry 39:326–331CrossRefPubMed
Liu F, Guo W, Liu L, Long Z, Ma C, Xue Z, Wang Y, Li J, Hu M, Zhang J, Du H, Zeng L, Liu Z, Wooderson SC, Tan C, Zhao J, Chen H (2013) Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study. J Affect Disord 146:401–406CrossRefPubMed
Liu F, Guo W, Fouche J-P, Wang Y, Wang W, Ding J, Zeng L, Qiu C, Gong Q, Zhang W (2015a) Multivariate classification of social anxiety disorder using whole brain functional connectivity. Brain Struct Funct 220:101–115CrossRef
Liu F, Xie B, Wang Y, Guo W, Fouche J-P, Long Z, Wang W, Chen H, Li M, Duan X (2015b) Characterization of post-traumatic stress disorder using resting-state fMRI with a multi-level parametric classification approach. Brain Topogr 28:221–237CrossRefPubMed
Liu F, Zhu C, Wang Y, Guo W, Li M, Wang W, Long Z, Meng Y, Cui Q, Zeng L, Gong Q, Zhang W, Chen H (2015c) Disrupted cortical hubs in functional brain networks in social anxiety disorder. Clin Neurophysiol 126:1711–1716CrossRefPubMed
Makris N, Kennedy DN, McInerney S, Sorensen AG, Wang R, Caviness VS, Pandya DN (2005) Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb Cortex 15:854–869CrossRefPubMed
Malt U (1988) The long-term psychiatric consequences of accidental injury. A longitudinal study of 107 adults. Br J Psychiatry 153:810–818CrossRefPubMed
Moores KA, Clark CR, McFarlane AC, Brown GC, Puce A, Taylor DJ (2008a) Abnormal recruitment of working memory updating networks during maintenance of trauma-neutral information in post-traumatic stress disorder. Psychiatry Res 163:156–170CrossRefPubMed
Moores KA, Clark CR, McFarlane AC, Brown GC, Puce A, Taylor DJ (2008b) Abnormal recruitment of working memory updating networks during maintenance of trauma-neutral information in post-traumatic stress disorder. Psychiatry Res 163:156–170CrossRefPubMed
Olff M, Polak AR, Witteveen AB, Denys D (2014) Executive function in posttraumatic stress disorder (PTSD) and the influence of comorbid depression. Neurobiol Learn Mem 112:114–121CrossRefPubMed
Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142–2154CrossRefPubMedPubMedCentral
Rauch SL, van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jenike MA, Pitman RK (1996) A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry 53:380–387CrossRefPubMed
Scolari M, Seidl-Rathkopf KN, Kastner S (2015) Functions of the human frontoparietal attention network: evidence from neuroimaging. Curr Opin Behav Sci 1:32–39CrossRef
Sripada RK, King AP, Garfinkel SN, Wang X, Sripada CS, Welsh RC, Liberzon I (2012) Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder. J Psychiatry Neurosci 37:241CrossRefPubMedPubMedCentral
Suo X, Lei D, Li K, Chen F, Li F, Li L, Huang X, Lui S, Li L, Kemp GJ (2015) Disrupted brain network topology in pediatric posttraumatic stress disorder: a resting-state fMRI study. Hum Brain Mapp 36:3677–3686CrossRefPubMed
Sylvester C, Corbetta M, Raichle M, Rodebaugh T, Schlaggar B, Sheline Y, Zorumski C, Lenze E (2012) Functional network dysfunction in anxiety and anxiety disorders. Trends Neurosci 35:527–535CrossRefPubMedPubMedCentral
Ungerleider L, Gaffan D, Pelak V (1989) Projections from inferior temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys. Exp Brain Res 76:473–484CrossRefPubMed
Vanni S, Tanskanen T, Seppä M, Uutela K, Hari R (2001) Coinciding early activation of the human primary visual cortex and anteromedial cuneus. Proc Natl Acad Sci 98:2776–2780CrossRefPubMedPubMedCentral
Vasterling JJ, Brailey K, Constans JI, Sutker PB (1998) Attention and memory dysfunction in posttraumatic stress disorder. Neuropsychology 12:125CrossRefPubMed
Wang J, Wang L, Zang Y, Yang H, Tang H, Gong Q, Chen Z, Zhu C, He Y (2009) Parcellation-dependent small-world brain functional networks: a resting-state fMRI study. Hum Brain Mapp 30:1511–1523CrossRefPubMed
Wang J, Zuo X, Dai Z, Xia M, Zhao Z, Zhao X, Jia J, Han Y, He Y (2013) Disrupted functional brain connectome in individuals at risk for Alzheimer’s disease. Biol Psychiatry 73:472–481CrossRefPubMed
White SF, Costanzo ME, Blair JR, Roy MJ (2015) PTSD symptom severity is associated with increased recruitment of top-down attentional control in a trauma-exposed sample. NeuroImage 7:19–27CrossRefPubMedPubMedCentral
Yago E, Duarte A, Wong T, Barceló F, Knight RT (2004) Temporal kinetics of prefrontal modulation of the extrastriate cortex during visual attention. Cogn Affect Behav Neurosci 4:609–617CrossRefPubMed
Yan C, Zang Y (2010) DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI. Front Syst Neurosci 4:13
Yin Y, Jin C, Hu X, Duan L, Li Z, Song M, Chen H, Feng B, Jiang T, Jin H (2011) Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study. Brain Res 1411:98–107PubMed
Zang Y, Jiang T, Lu Y, He Y, Tian L (2004) Regional homogeneity approach to fMRI data analysis. Neuroimage 22:394–400CrossRefPubMed
Zatzick DF, Marmar CR, Weiss DS, Browner WS, Metzler TJ, Golding JM, Stewart A, Schlenger WE, Wells KB (1997) Posttraumatic stress disorder and functioning and quality of life outcomes in a nationally representative sample of male Vietnam veterans. Am J Psychiatry 154:1690–1695CrossRefPubMed
Zhang Z, Liu Y, Jiang T, Zhou B, An N, Dai H, Wang P, Niu Y, Wang L, Zhang X (2012) Altered spontaneous activity in Alzheimer’s disease and mild cognitive impairment revealed by Regional Homogeneity. Neuroimage 59:1429–1440CrossRefPubMed
Zuo X-N, Xing X-X (2014) Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. Neurosci Biobehav R 45:100–118CrossRef
Metadata
Title
Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder
Authors
Youxue Zhang
Bing Xie
Heng Chen
Meiling Li
Feng Liu
Huafu Chen
Publication date
01-05-2016
Publisher
Springer US
Published in
Brain Topography / Issue 3/2016
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI
https://doi.org/10.1007/s10548-016-0472-8

Other articles of this Issue 3/2016

Brain Topography 3/2016 Go to the issue

Original Paper

Connectivity Analysis and Feature Classification in Attention Deficit Hyperactivity Disorder Sub-Types: A Task Functional Magnetic Resonance Imaging Study

Original Paper

A Permutation Test for Unbalanced Paired Comparisons of Global Field Power

Original Paper

Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome

Original Paper

Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor

Original Paper

Attentional Network Differences Between Migraineurs and Non-migraine Controls: fMRI Evidence

Original Paper

Functional Connectivity and Quantitative EEG in Women with Alcohol Use Disorders: A Resting-State Study