Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Brain Topography
Published in: Brain Topography 3/2016

01-05-2016 | Original Paper

Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor

Authors: Wenjie Yin, Wei Lin, Wenbo Li, Shusen Qian, Xin Mou

Published in: Brain Topography | Issue 3/2016

Login to get access

Abstract

Individuals with essential tremor (ET) have postural and active movement abnormalities. Disturbances in the cerebello-thalamo-cortical circuit may contribute to the several motor symptoms of ET. Resting state fMRI provides a valuable, noninvasive tool to study intrinsic activation in the human brain, particularly in the brains of individuals with neuropsychiatric diseases. To investigate the low frequency oscillation features of intrinsic activation in ET in this study, we performed a resting state fMRI analysis in 24 patients with ET and 23 healthy controls. The amplitudes of low frequency fluctuation (ALFF) were analyzed. When compared with healthy controls, patients showed significantly enhanced ALFF in the bilateral cerebral cortex, which is related to motor function, including the pre- and post-central gyrus, supplementary motor area and paracentral lobule. The larger ALFF value in the right precentral gyrus is related to a longer duration of tremor. The decreased ALFF in the bilateral cerebellum was also observed in patients. In addition, aberrant ALFF in the right cerebellar tonsil was negatively associated with the duration of tremor. Our findings suggest that abnormalities exist in the intrinsic activation of brain regions in patients with ET. These findings provide noninvasive evidence that supports the hypothesis that the abnormality of intrinsic activity in the cerebello-cerebral cortex pathway could be associated with the motor-related symptoms of ET. Furthermore, the duration of a tremor might relate to the severity of the alterations to the motor system of ET.
Literature
Bagepally BS et al (2012) Decrease in cerebral and cerebellar gray matter in essential tremor: a voxel-based morphometric analysis under 3T MRI. J Neuroimaging 22(3):275–278CrossRefPubMed
Bhalsing KS, Saini J, Pal PK (2013) Understanding the pathophysiology of essential tremor through advanced neuroimaging: a review. J Neurol Sci 335(1–2):9–13CrossRefPubMed
Chen X et al (2015) Functional disconnection between the visual cortex and the sensorimotor cortex suggests a potential mechanism for self-disorder in schizophrenia. Schizophr Res 166:151–157CrossRefPubMed
Deuschl G, Bain P, Brin M (1998) Consensus statement of the Movement Disorder Society on tremor. Ad Hoc Scientific Committee. Mov Disord 13(Suppl 3):2–23PubMed
Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8(9):700–711CrossRefPubMed
Fox MD et al (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci USA 102(27):9673–9678CrossRefPubMedPubMedCentral
Gallea C et al (2015) Intrinsic signature of essential tremor in the cerebello-frontal network. Brain 138:2920–2933CrossRefPubMed
Grimaldi G, Manto M (2013) Is essential tremor a Purkinjopathy? The role of the cerebellar cortex in its pathogenesis. Mov Disord 28(13):1759–1761CrossRefPubMed
Haier RJ et al (2003) Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology 61(12):1673–1679CrossRefPubMed
Hansel C (2009) Reading the clock: how Purkinje cells decode the phase of olivary oscillations. Neuron 62(3):308–309CrossRefPubMed
Jarque CM, Bera AK (1980) Efficient tests for normality, homoscedasticity and serial independence of regression residuals. Econ Lett 6(3):255–259CrossRef
Jiang S et al (2016) Altered local spontaneous brain activity in juvenile myoclonic epilepsy: a preliminary resting-state fMRI study. Neural Plast 2016:7
Klein JC et al (2011) Diffusion tensor imaging of white matter involvement in essential tremor. Hum Brain Mapp 32(6):896–904CrossRefPubMed
Li Q et al (2015) Altered resting state functional network connectivity in children absence epilepsy. J Neurol Sci 354(1–2):79–85CrossRefPubMed
Louis ED (2010) Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry. Lancet Neurol 9(6):613–622CrossRefPubMed
Louis ED, Ferreira JJ (2010) How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 25(5):534–541CrossRefPubMed
Louis ED et al (2007) Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 130(Pt 12):3297–3307CrossRefPubMed
Luo C et al (2011) Altered functional connectivity in default mode network in absence epilepsy: a resting-state fMRI study. Hum Brain Mapp 32(3):438–449CrossRefPubMed
Luo C et al (2012a) Disrupted functional brain connectivity in partial epilepsy: a resting-state fMRI study. PLoS One 7(1):e28196CrossRefPubMedCentral
Luo C et al (2012b) Resting state basal ganglia network in idiopathic generalized epilepsy. Hum Brain Mapp 33(6):1279–1294CrossRefPubMed
Luo C et al (2015) Altered structural and functional feature of striato-cortical circuit in benign epilepsy with centrotemporal spikes. Int J Neural Syst 25:1550027CrossRefPubMed
Maier MA et al (2002) Differences in the corticospinal projection from primary motor cortex and supplementary motor area to macaque upper limb motoneurons: an anatomical and electrophysiological study. Cereb Cortex 12(3):281–296CrossRefPubMed
Menon RS (2002) Postacquisition suppression of large-vessel BOLD signals in high-resolution fMRI. Magn Reson Med 47(1):1–9CrossRefPubMed
Neely KA et al (2014) Functional brain activity relates to 0–3 and 3–8 Hz force oscillations in essential tremor. Cereb Cortex 25:4191–4202CrossRefPubMed
O’Hearn E, Molliver ME (1997) The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity. J Neurosci 17(22):8828–8841PubMed
Raethjen J, Deuschl G (2012) The oscillating central network of essential tremor. Clin Neurophysiol 123(1):61–64CrossRefPubMed
Tan Y et al (2015) Altered brain activation in early drug-naive Parkinson’s disease during heat pain stimuli: an fMRI study. Parkinsons Dis 2015:273019PubMedPubMedCentral
Wang Z et al (2011) Spatial patterns of intrinsic brain activity in mild cognitive impairment and Alzheimer’s disease: a resting-state functional MRI study. Hum Brain Mapp 32(10):1720–1740CrossRefPubMed
Xue K et al (2014) Diffusion tensor tractography reveals disrupted structural connectivity in childhood absence epilepsy. Epilepsy Res 108(1):125–138CrossRefPubMed
Zang YF et al (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 29(2):83–91CrossRefPubMed
Zhang Z et al (2010) fMRI study of mesial temporal lobe epilepsy using amplitude of low-frequency fluctuation analysis. Hum Brain Mapp 31(12):1851–1861CrossRefPubMed
Metadata
Title
Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor
Authors
Wenjie Yin
Wei Lin
Wenbo Li
Shusen Qian
Xin Mou
Publication date
01-05-2016
Publisher
Springer US
Published in
Brain Topography / Issue 3/2016
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI
https://doi.org/10.1007/s10548-016-0474-6

Other articles of this Issue 3/2016

Brain Topography 3/2016 Go to the issue

Original Paper

Modalities of Thinking: State and Trait Effects on Cross-Frequency Functional Independent Brain Networks

Original Paper

Attentional Network Differences Between Migraineurs and Non-migraine Controls: fMRI Evidence

Original Paper

Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome

Original Paper

Detectability of Fast Ripples (>250 Hz) on the Scalp EEG: A Proof-of-Principle Study with Subdermal Electrodes

Original Paper

Connectivity Analysis and Feature Classification in Attention Deficit Hyperactivity Disorder Sub-Types: A Task Functional Magnetic Resonance Imaging Study

Original Paper

Electrocortical Dynamics in Children with a Language-Learning Impairment Before and After Audiovisual Training