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Open Access 01-05-2018 | Metabolomics

Advances in metabolome information retrieval: turning chemistry into biology. Part II: biological information recovery

Authors: Abdellah Tebani, Carlos Afonso, Soumeya Bekri

Published in: Journal of Inherited Metabolic Disease | Issue 3/2018

Abstract

This work reports the second part of a review intending to give the state of the art of major metabolic phenotyping strategies. It particularly deals with inherent advantages and limits regarding data analysis issues and biological information retrieval tools along with translational challenges. This Part starts with introducing the main data preprocessing strategies of the different metabolomics data. Then, it describes the main data analysis techniques including univariate and multivariate aspects. It also addresses the challenges related to metabolite annotation and characterization. Finally, functional analysis including pathway and network strategies are discussed. The last section of this review is devoted to practical considerations and current challenges and pathways to bring metabolomics into clinical environments.

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Title: Advances in metabolome information retrieval: turning chemistry into biology. Part II: biological information recovery
Authors: Abdellah Tebani
Carlos Afonso
Soumeya Bekri
Publication date: 01-05-2018
Publisher: Springer Netherlands
Published in: Journal of Inherited Metabolic Disease / Issue 3/2018
Print ISSN: 0141-8955
Electronic ISSN: 1573-2665
DOI: https://doi.org/10.1007/s10545-017-0080-0

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