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Published in: AIDS and Behavior 3/2018

01-03-2018 | Original Paper

HIV Linkage to Care and Retention in Care Rate Among MSM in Guangzhou, China

Authors: Ngai Sze Wong, Jessica Mao, Weibin Cheng, Weiming Tang, Myron S. Cohen, Joseph D. Tucker, Huifang Xu

Published in: AIDS and Behavior | Issue 3/2018

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Abstract

Quantifying HIV service provision along the HIV care continuum is increasingly important for monitoring and evaluating HIV interventions. We examined factors associated with linkage and retention in care longitudinally among MSM (n = 1974, 4933 person-years) diagnosed and living in Guangzhou, China, in 2008–2014. We measured longitudinal change of retention in care (≥2 CD4 tests per year) from linkage and antiretroviral therapy initiation (ART). We examined factors associated with linkage using logistic regression and with retention using generalized estimating equations. The rate of linkage to care was 89% in 2014. ART retention rate dropped from 71% (year 1) to 46% (year 2), suggesting that first-year retention measures likely overestimate retention over longer periods. Lower CD4 levels and older age predicted retention in ART care. These data can inform interventions to improve retention about some subgroups.
Literature
1.
go back to reference Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52(6):793–800.CrossRefPubMedPubMedCentral Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52(6):793–800.CrossRefPubMedPubMedCentral
2.
go back to reference Tang W, Han L, Best J, et al. Crowdsourcing HIV test promotion videos: a noninferiority randomized controlled trial in China. Clin Infect Dis. 2016;62(11):1436–42.CrossRefPubMedPubMedCentral Tang W, Han L, Best J, et al. Crowdsourcing HIV test promotion videos: a noninferiority randomized controlled trial in China. Clin Infect Dis. 2016;62(11):1436–42.CrossRefPubMedPubMedCentral
3.
4.
go back to reference Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Def Synd. 2005;39:446–53.CrossRef Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Def Synd. 2005;39:446–53.CrossRef
5.
go back to reference Maulsby C, Jain KM, Weir BW, et al. The cost and threshold analysis of retention in care (RiC): a Multi-Site National HIV Care Program. AIDS Behav. 2017;21(3):643–9.CrossRefPubMed Maulsby C, Jain KM, Weir BW, et al. The cost and threshold analysis of retention in care (RiC): a Multi-Site National HIV Care Program. AIDS Behav. 2017;21(3):643–9.CrossRefPubMed
6.
go back to reference Skarbinski J, Rosenberg E, Paz-Bailey G, et al. Human immunodeficiency virus transmission at each step of the care continuum in the United States. JAMA Intern Med. 2015;175(4):588–96.CrossRefPubMed Skarbinski J, Rosenberg E, Paz-Bailey G, et al. Human immunodeficiency virus transmission at each step of the care continuum in the United States. JAMA Intern Med. 2015;175(4):588–96.CrossRefPubMed
7.
go back to reference Koenig SP, Bernard D, Devieux JG, et al. Trends in CD4 count testing, retention in pre-ART care, and ART initiation rates over the first decade of expansion of HIV services in Haiti. PLoS ONE. 2016;11(2):e0146903.CrossRefPubMedPubMedCentral Koenig SP, Bernard D, Devieux JG, et al. Trends in CD4 count testing, retention in pre-ART care, and ART initiation rates over the first decade of expansion of HIV services in Haiti. PLoS ONE. 2016;11(2):e0146903.CrossRefPubMedPubMedCentral
8.
go back to reference Cornell M, Grimsrud A, Fairall L, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002–2007. AIDS. 2010;24(14):2263–70.CrossRefPubMedPubMedCentral Cornell M, Grimsrud A, Fairall L, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002–2007. AIDS. 2010;24(14):2263–70.CrossRefPubMedPubMedCentral
9.
go back to reference Westergaard RP, Hess T, Astemborski J, Mehta SH, Kirk GD. Longitudinal changes in engagement in care and viral suppression for HIV-infected injection drug users. AIDS. 2013;27(16):2559–66.CrossRefPubMedPubMedCentral Westergaard RP, Hess T, Astemborski J, Mehta SH, Kirk GD. Longitudinal changes in engagement in care and viral suppression for HIV-infected injection drug users. AIDS. 2013;27(16):2559–66.CrossRefPubMedPubMedCentral
10.
go back to reference Zhu H, Napravnik S, Eron J, et al. Attrition among human immunodeficiency virus (HIV)- infected patients initiating antiretroviral therapy in China, 2003–2010. PLoS ONE. 2012;7(6):e39414.CrossRefPubMedPubMedCentral Zhu H, Napravnik S, Eron J, et al. Attrition among human immunodeficiency virus (HIV)- infected patients initiating antiretroviral therapy in China, 2003–2010. PLoS ONE. 2012;7(6):e39414.CrossRefPubMedPubMedCentral
11.
go back to reference McNairy ML, Lamb MR, Abrams EJ, et al. Use of a Comprehensive HIV care cascade for evaluating HIV Program Performance: findings from 4 Sub-Saharan African countries. J Acquir Immune Defic Syndr. 2015;70(2):e44–51.CrossRefPubMedPubMedCentral McNairy ML, Lamb MR, Abrams EJ, et al. Use of a Comprehensive HIV care cascade for evaluating HIV Program Performance: findings from 4 Sub-Saharan African countries. J Acquir Immune Defic Syndr. 2015;70(2):e44–51.CrossRefPubMedPubMedCentral
12.
go back to reference Clouse K, Pettifor AE, Maskew M, et al. Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary health care clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2013;62(2):e39–46.CrossRefPubMedPubMedCentral Clouse K, Pettifor AE, Maskew M, et al. Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary health care clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2013;62(2):e39–46.CrossRefPubMedPubMedCentral
13.
go back to reference Haas AD, Tenthani L, Msukwa MT, et al. Retention in care during the first 3 years of antiretroviral therapy for women in Malawi’s option B+ programme: an observational cohort study. Lancet HIV. 2016;3(4):e175–82.CrossRefPubMedPubMedCentral Haas AD, Tenthani L, Msukwa MT, et al. Retention in care during the first 3 years of antiretroviral therapy for women in Malawi’s option B+ programme: an observational cohort study. Lancet HIV. 2016;3(4):e175–82.CrossRefPubMedPubMedCentral
14.
go back to reference McFall AM, Mehta SH, Srikrishnan AK, et al. Getting to 90: linkage to HIV care among men who have sex with men and people who inject drugs in India. AIDS Care. 2016;28(10):1230–9.CrossRefPubMedPubMedCentral McFall AM, Mehta SH, Srikrishnan AK, et al. Getting to 90: linkage to HIV care among men who have sex with men and people who inject drugs in India. AIDS Care. 2016;28(10):1230–9.CrossRefPubMedPubMedCentral
15.
go back to reference Parchure R, Kulkarni V, Kulkarni S, Gangakhedkar R. Pattern of linkage and retention in HIV care continuum among patients attending referral HIV care clinic in private sector in India. AIDS Care. 2015;27(6):716–22.CrossRefPubMed Parchure R, Kulkarni V, Kulkarni S, Gangakhedkar R. Pattern of linkage and retention in HIV care continuum among patients attending referral HIV care clinic in private sector in India. AIDS Care. 2015;27(6):716–22.CrossRefPubMed
16.
go back to reference National Health and Family Planning Commission of the People’s Republic of China. 2015 China AIDS Response Progress Report. Beijing, China May 2015 2015. National Health and Family Planning Commission of the People’s Republic of China. 2015 China AIDS Response Progress Report. Beijing, China May 2015 2015.
17.
go back to reference Wu Z, Sullivan SG, Wang Y, Rotheram-Borus MJ, Detels R. Evolution of China’s response to HIV/AIDS. Lancet. 2007;369(9562):679–90.CrossRefPubMed Wu Z, Sullivan SG, Wang Y, Rotheram-Borus MJ, Detels R. Evolution of China’s response to HIV/AIDS. Lancet. 2007;369(9562):679–90.CrossRefPubMed
18.
go back to reference Zhang F, Dou Z, Ma Y, et al. Five-year outcomes of the China National Free Antiretroviral Treatment Program. Ann Intern Med. 2009;151(4):241–51.CrossRefPubMed Zhang F, Dou Z, Ma Y, et al. Five-year outcomes of the China National Free Antiretroviral Treatment Program. Ann Intern Med. 2009;151(4):241–51.CrossRefPubMed
20.
go back to reference Zhang D, Li C, Meng S, Qi J, Fu X, Sun J. Attrition of MSM with HIV/AIDS along the continuum of care from screening to CD4 testing in China. AIDS Care. 2014;26(9):1118–21.CrossRefPubMed Zhang D, Li C, Meng S, Qi J, Fu X, Sun J. Attrition of MSM with HIV/AIDS along the continuum of care from screening to CD4 testing in China. AIDS Care. 2014;26(9):1118–21.CrossRefPubMed
21.
go back to reference Chow EP, Muessig KE, Yuan L, et al. Risk behaviours among female sex workers in China: a systematic review and data synthesis. PLoS ONE. 2015;10(3):e0120595.CrossRefPubMedPubMedCentral Chow EP, Muessig KE, Yuan L, et al. Risk behaviours among female sex workers in China: a systematic review and data synthesis. PLoS ONE. 2015;10(3):e0120595.CrossRefPubMedPubMedCentral
22.
go back to reference Yang GL, Yan J, Liu Y, Huang ZL, Long S. Retention in care and factors affecting it among people living with HIV/AIDS in Changsha City, China. Asia Pac J Public Health. 2015;27(2 Suppl):86s–92s.CrossRefPubMed Yang GL, Yan J, Liu Y, Huang ZL, Long S. Retention in care and factors affecting it among people living with HIV/AIDS in Changsha City, China. Asia Pac J Public Health. 2015;27(2 Suppl):86s–92s.CrossRefPubMed
23.
go back to reference Zhong F, Liang B, Xu H, et al. Increasing HIV and decreasing syphilis prevalence in a context of persistently high unprotected anal intercourse, six consecutive annual surveys among men who have sex with men in Guangzhou, China, 2008–2013. PLoS ONE. 2014;9(7):e103136.CrossRefPubMedPubMedCentral Zhong F, Liang B, Xu H, et al. Increasing HIV and decreasing syphilis prevalence in a context of persistently high unprotected anal intercourse, six consecutive annual surveys among men who have sex with men in Guangzhou, China, 2008–2013. PLoS ONE. 2014;9(7):e103136.CrossRefPubMedPubMedCentral
24.
go back to reference Zhang L, Chow EP, Zhang J, Jing J, Wilson DP. Describing the Chinese HIV surveillance system and the influences of political structures and social stigma. Open AIDS J. 2012;6:163–8.CrossRefPubMedPubMedCentral Zhang L, Chow EP, Zhang J, Jing J, Wilson DP. Describing the Chinese HIV surveillance system and the influences of political structures and social stigma. Open AIDS J. 2012;6:163–8.CrossRefPubMedPubMedCentral
25.
go back to reference Christopoulos KA, Das M, Colfax GN. Linkage and retention in HIV care among men who have sex with men in the United States. Clin Infect Dis. 2011;52(Suppl 2):S214–22.CrossRefPubMedPubMedCentral Christopoulos KA, Das M, Colfax GN. Linkage and retention in HIV care among men who have sex with men in the United States. Clin Infect Dis. 2011;52(Suppl 2):S214–22.CrossRefPubMedPubMedCentral
26.
go back to reference Hanley JA, Negassa A, Edwardes MD, Forrester JE. Statistical analysis of correlated data using generalized estimating equations: an orientation. Am J Epidemiol. 2003;157(4):364–75.CrossRefPubMed Hanley JA, Negassa A, Edwardes MD, Forrester JE. Statistical analysis of correlated data using generalized estimating equations: an orientation. Am J Epidemiol. 2003;157(4):364–75.CrossRefPubMed
27.
go back to reference Yan H, Zhang R, Wei C, et al. A peer-led, community-based rapid HIV testing intervention among untested men who have sex with men in China: an operational model for expansion of HIV testing and linkage to care. Sex Transm Infect. 2014;90(5):388–93.CrossRefPubMed Yan H, Zhang R, Wei C, et al. A peer-led, community-based rapid HIV testing intervention among untested men who have sex with men in China: an operational model for expansion of HIV testing and linkage to care. Sex Transm Infect. 2014;90(5):388–93.CrossRefPubMed
28.
go back to reference Eberhart MG, Yehia BR, Hillier A, et al. Behind the cascade: analyzing spatial patterns along the HIV care continuum. J Acquir Immune Defic Syndr. 2013;64(Suppl 1):S42–51.CrossRefPubMedPubMedCentral Eberhart MG, Yehia BR, Hillier A, et al. Behind the cascade: analyzing spatial patterns along the HIV care continuum. J Acquir Immune Defic Syndr. 2013;64(Suppl 1):S42–51.CrossRefPubMedPubMedCentral
29.
go back to reference Nosyk B, Montaner JS, Colley G, et al. The cascade of HIV care in British Columbia, Canada, 1996–2011: a population-based retrospective cohort study. Lancet Infect Dis. 2014;14(1):40–9.CrossRefPubMed Nosyk B, Montaner JS, Colley G, et al. The cascade of HIV care in British Columbia, Canada, 1996–2011: a population-based retrospective cohort study. Lancet Infect Dis. 2014;14(1):40–9.CrossRefPubMed
30.
go back to reference Belza MJ, Hoyos J, Fernandez-Balbuena S, et al. Assessment of an outreach street-based HIV rapid testing programme as a strategy to promote early diagnosis: a comparison with two surveillance systems in Spain, 2008–2011. Euro Surveill. 2015;20(14):23–33.CrossRef Belza MJ, Hoyos J, Fernandez-Balbuena S, et al. Assessment of an outreach street-based HIV rapid testing programme as a strategy to promote early diagnosis: a comparison with two surveillance systems in Spain, 2008–2011. Euro Surveill. 2015;20(14):23–33.CrossRef
31.
go back to reference Suthar AB, Ford N, Bachanas PJ, et al. Towards universal voluntary HIV testing and counselling: a systematic review and meta-analysis of community-based approaches. PLoS Med. 2013;10(8):e1001496.CrossRefPubMedPubMedCentral Suthar AB, Ford N, Bachanas PJ, et al. Towards universal voluntary HIV testing and counselling: a systematic review and meta-analysis of community-based approaches. PLoS Med. 2013;10(8):e1001496.CrossRefPubMedPubMedCentral
32.
go back to reference Robertson M, Wei SC, Beer L, et al. Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA. AIDS Care. 2016;28(3):325–33.CrossRefPubMed Robertson M, Wei SC, Beer L, et al. Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA. AIDS Care. 2016;28(3):325–33.CrossRefPubMed
33.
go back to reference Zhang D, Lu H, Zhuang M, et al. Enhancing HIV testing and treatment among men who have sex with men in China: a pilot model with two-rapid tests, single blood draw session, and intensified case management in six cities in 2013. PLoS ONE. 2016;11(12):e0166812.CrossRefPubMedPubMedCentral Zhang D, Lu H, Zhuang M, et al. Enhancing HIV testing and treatment among men who have sex with men in China: a pilot model with two-rapid tests, single blood draw session, and intensified case management in six cities in 2013. PLoS ONE. 2016;11(12):e0166812.CrossRefPubMedPubMedCentral
34.
go back to reference Tucker JD, Muessig KE, Cui R, et al. Organizational characteristics of HIV/syphilis testing services for men who have sex with men in South China: a social entrepreneurship analysis and implications for creating sustainable service models. BMC Infect Dis. 2014;14:601.CrossRefPubMedPubMedCentral Tucker JD, Muessig KE, Cui R, et al. Organizational characteristics of HIV/syphilis testing services for men who have sex with men in South China: a social entrepreneurship analysis and implications for creating sustainable service models. BMC Infect Dis. 2014;14:601.CrossRefPubMedPubMedCentral
35.
go back to reference Vinikoor MJ, Joseph J, Mwale J, et al. Age at antiretroviral therapy initiation predicts immune recovery, death, and loss to follow-up among HIV-infected adults in urban Zambia. AIDS Res Hum Retroviruses. 2014;30(10):949–55.CrossRefPubMedPubMedCentral Vinikoor MJ, Joseph J, Mwale J, et al. Age at antiretroviral therapy initiation predicts immune recovery, death, and loss to follow-up among HIV-infected adults in urban Zambia. AIDS Res Hum Retroviruses. 2014;30(10):949–55.CrossRefPubMedPubMedCentral
36.
go back to reference Lall P, Lim SH, Khairuddin N, Kamarulzaman A. Review: an urgent need for research on factors impacting adherence to and retention in care among HIV-positive youth and adolescents from key populations. J Int AIDS Soc. 2015;18(2 Suppl 1):19393.PubMedPubMedCentral Lall P, Lim SH, Khairuddin N, Kamarulzaman A. Review: an urgent need for research on factors impacting adherence to and retention in care among HIV-positive youth and adolescents from key populations. J Int AIDS Soc. 2015;18(2 Suppl 1):19393.PubMedPubMedCentral
37.
go back to reference Wong NS, Reidpath DD, Wong KH, Lee SS. A multilevel approach to assessing temporal change of CD4 recovery following HAART initiation in a cohort of Chinese HIV positive patients. J Infect. 2015;70(6):676–8.CrossRefPubMed Wong NS, Reidpath DD, Wong KH, Lee SS. A multilevel approach to assessing temporal change of CD4 recovery following HAART initiation in a cohort of Chinese HIV positive patients. J Infect. 2015;70(6):676–8.CrossRefPubMed
38.
go back to reference Naftalin CM, Wong NS, Chan DP, Wong KH, Reidpath DD, Lee SS. Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy—a five-year observational study. Int J STD AIDS. 2015;2015(26):803–9.CrossRef Naftalin CM, Wong NS, Chan DP, Wong KH, Reidpath DD, Lee SS. Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy—a five-year observational study. Int J STD AIDS. 2015;2015(26):803–9.CrossRef
39.
go back to reference Wu Z, Zhao Y, Ge X, et al. Simplified HIV testing and treatment in China: analysis of mortality rates before and after a structural intervention. PLoS Med. 2015;12(9):e1001874.CrossRefPubMedPubMedCentral Wu Z, Zhao Y, Ge X, et al. Simplified HIV testing and treatment in China: analysis of mortality rates before and after a structural intervention. PLoS Med. 2015;12(9):e1001874.CrossRefPubMedPubMedCentral
40.
go back to reference State Council Office. [China’s 13th Five-year Action Plan for Reducing and Preventing the Spread of HIV/AIDS (2016–2020)]. Beijing. 2017. State Council Office. [China’s 13th Five-year Action Plan for Reducing and Preventing the Spread of HIV/AIDS (2016–2020)]. Beijing. 2017.
41.
go back to reference Zhou W, Zhao M, Wang X, et al. Treatment adherence and health outcomes in MSM with HIV/AIDS: patients enrolled in “one-stop” and standard care clinics in Wuhan China. PLoS ONE. 2014;9(12):e113736.CrossRefPubMedPubMedCentral Zhou W, Zhao M, Wang X, et al. Treatment adherence and health outcomes in MSM with HIV/AIDS: patients enrolled in “one-stop” and standard care clinics in Wuhan China. PLoS ONE. 2014;9(12):e113736.CrossRefPubMedPubMedCentral
42.
go back to reference Ning C, Smith KM, McCann CD, et al. Outcome of sentinel hospital-based and CDC-based ART service delivery: a prospective open cohort of people living with HIV in China. Sci Rep. 2017;7:42637.CrossRefPubMedPubMedCentral Ning C, Smith KM, McCann CD, et al. Outcome of sentinel hospital-based and CDC-based ART service delivery: a prospective open cohort of people living with HIV in China. Sci Rep. 2017;7:42637.CrossRefPubMedPubMedCentral
Metadata
Title
HIV Linkage to Care and Retention in Care Rate Among MSM in Guangzhou, China
Authors
Ngai Sze Wong
Jessica Mao
Weibin Cheng
Weiming Tang
Myron S. Cohen
Joseph D. Tucker
Huifang Xu
Publication date
01-03-2018
Publisher
Springer US
Published in
AIDS and Behavior / Issue 3/2018
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-017-1893-4

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