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01-01-2018 | Original Paper

A Simple Risk Prediction Algorithm for HIV Transmission: Results from HIV Prevention Trials in KwaZulu Natal, South Africa (2002–2012)

Authors: Handan Wand, Tarylee Reddy, Sarita Naidoo, Suri Moonsamy, Samantha Siva, Neetha S. Morar, Gita Ramjee

Published in: AIDS and Behavior | Issue 1/2018

Abstract

We aimed to develop a HIV risk scoring algorithm for targeted screening among women in South Africa. We used data from five biomedical intervention trials (N = 8982 Cox regression models were used to create a risk prediction algorithm and it was internally and externally validated using standard statistical measures; 7-factors were identified as significant predictors of HIV infection: <25 years old, being single/not cohabiting, parity (<3), age at sexual debut (<16), 3+ sexual partners, using injectables and diagnosis with a sexually transmitted infection(s). A score of ≥25 (out of 50) was the optimum cut point with 83% (80%) sensitivity in the development (validation) dataset. Our tool can be used in designing future HIV prevention research and guiding recruitment strategies as well as in health care settings. Identifying, targeting and prioritising women at highest risk will have significant impact on preventing new HIV infections by scaling up testing and pre-exposure prophylaxis in conjunction with other HIV prevention modalities.

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Title: A Simple Risk Prediction Algorithm for HIV Transmission: Results from HIV Prevention Trials in KwaZulu Natal, South Africa (2002–2012)
Authors: Handan Wand
Tarylee Reddy
Sarita Naidoo
Suri Moonsamy
Samantha Siva
Neetha S. Morar
Gita Ramjee
Publication date: 01-01-2018
Publisher: Springer US
Published in: AIDS and Behavior / Issue 1/2018
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-017-1785-7

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