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Published in: AIDS and Behavior 6/2018

01-06-2018 | Original Paper

Physical Activity is Associated with Metabolic Health in Men Living with HIV

Authors: Cuisle Forde, Aisling Loy, Siobhan O’Dea, Fiona Mulcahy, John Gormley, Caroline Daly

Published in: AIDS and Behavior | Issue 6/2018

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Abstract

Metabolic health is a cause for concern among those living with HIV, especially those on antiretroviral therapy. Physical activity (PA) is known to benefit metabolic health, however, few studies have objectively measured PA or investigated the relationship between PA and metabolic health among those living with HIV. In this study, PA and indices of metabolic health among twenty men living with HIV and twenty age matched HIV-negative men were measured. PA was measured using Actigraph accelerometers. Components of the metabolic syndrome and insulin resistance were measured using routine laboratory methods. Men living with HIV were significantly more physically active than HIV-negative men, and were reaching public PA guidelines. Significant inverse correlations between moderate PA and both insulin resistance (ρ −0.847; p < 0.001) and triglycerides (ρ −0.575; p = 0.013) were seen in those living with HIV. Results of this study emphasize the importance of an active lifestyle for those living with HIV.
Literature
1.
go back to reference Mayor AM, Gomez MA, Rios-Oliveras E, Hunter-Mellado RF. Mortality trends of HIV-infected patients after the introduction of highly active antiretroviral therapy: analysis of a cohort of 3,322 HIV-infected persons. Ethn Dis. 2005;15(4 Suppl 5):S5-57–62. Mayor AM, Gomez MA, Rios-Oliveras E, Hunter-Mellado RF. Mortality trends of HIV-infected patients after the introduction of highly active antiretroviral therapy: analysis of a cohort of 3,322 HIV-infected persons. Ethn Dis. 2005;15(4 Suppl 5):S5-57–62.
2.
go back to reference Leow MK, Addy CL, Mantzoros CS. Clinical review 159: human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab. 2003;88(5):1961–76.CrossRefPubMed Leow MK, Addy CL, Mantzoros CS. Clinical review 159: human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab. 2003;88(5):1961–76.CrossRefPubMed
3.
go back to reference Anuurad E, Semrad A, Berglund L. Human immunodeficiency virus and highly active antiretroviral therapy-associated metabolic disorders and risk factors for cardiovascular disease. Metab Syndr Relat Disord. 2009;7(5):401–10.CrossRefPubMedCentralPubMed Anuurad E, Semrad A, Berglund L. Human immunodeficiency virus and highly active antiretroviral therapy-associated metabolic disorders and risk factors for cardiovascular disease. Metab Syndr Relat Disord. 2009;7(5):401–10.CrossRefPubMedCentralPubMed
4.
go back to reference Lombo B, Alkhalil I, Golden MP, Fotjadhi I, Ravi S, Virata M, et al. Prevalence of metabolic syndrome in patients with HIV in the era of highly active antiretroviral therapy. Conn Med. 2015;79(5):277–81.PubMed Lombo B, Alkhalil I, Golden MP, Fotjadhi I, Ravi S, Virata M, et al. Prevalence of metabolic syndrome in patients with HIV in the era of highly active antiretroviral therapy. Conn Med. 2015;79(5):277–81.PubMed
5.
go back to reference Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59.CrossRefPubMed Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59.CrossRefPubMed
6.
go back to reference O’Brien K, Nixon S, Tynan AM, Glazier RH. Effectiveness of aerobic exercise in adults living with HIV/AIDS: systematic review. Med Sci Sports Exerc. 2004;36(10):1659–66.CrossRefPubMed O’Brien K, Nixon S, Tynan AM, Glazier RH. Effectiveness of aerobic exercise in adults living with HIV/AIDS: systematic review. Med Sci Sports Exerc. 2004;36(10):1659–66.CrossRefPubMed
7.
go back to reference Blashill AJ, Mayer KH, Crane H, Magidson JF, Grasso C, Mathews WC, et al. Physical activity and health outcomes among HIV-infected men who have sex with men: a longitudinal mediational analysis. Ann Behav Med. 2013;46(2):149–56.CrossRefPubMedCentralPubMed Blashill AJ, Mayer KH, Crane H, Magidson JF, Grasso C, Mathews WC, et al. Physical activity and health outcomes among HIV-infected men who have sex with men: a longitudinal mediational analysis. Ann Behav Med. 2013;46(2):149–56.CrossRefPubMedCentralPubMed
8.
go back to reference Alencastro PR, Fuchs SC, Wolff FH, Ikeda ML, Brandao AB, Barcellos NT. Independent predictors of metabolic syndrome in HIV-infected patients. AIDS Patient Care STDs. 2011;25(11):627–34.CrossRefPubMed Alencastro PR, Fuchs SC, Wolff FH, Ikeda ML, Brandao AB, Barcellos NT. Independent predictors of metabolic syndrome in HIV-infected patients. AIDS Patient Care STDs. 2011;25(11):627–34.CrossRefPubMed
9.
go back to reference Schuelter-Trevisol F, Wolff FH, Alencastro PR, Grigoletti S, Ikeda ML, Brandao AB, et al. Physical activity: do patients infected with HIV practice? How much? A systematic review. Curr HIV Res. 2012;10(6):487–97.CrossRefPubMed Schuelter-Trevisol F, Wolff FH, Alencastro PR, Grigoletti S, Ikeda ML, Brandao AB, et al. Physical activity: do patients infected with HIV practice? How much? A systematic review. Curr HIV Res. 2012;10(6):487–97.CrossRefPubMed
10.
go back to reference van Poppel MN, Chinapaw MJ, Mokkink LB, van Mechelen W, Terwee CB. Physical activity questionnaires for adults: a systematic review of measurement properties. Sports Med. 2010;40(7):565–600.CrossRefPubMed van Poppel MN, Chinapaw MJ, Mokkink LB, van Mechelen W, Terwee CB. Physical activity questionnaires for adults: a systematic review of measurement properties. Sports Med. 2010;40(7):565–600.CrossRefPubMed
11.
go back to reference Tierney M, Fraser A, Kennedy N. Criterion validity of the international physical activity questionnaire short form (IPAQ-SF) for use in patients with rheumatoid arthritis: comparison with the SenseWear Armband. Physiotherapy. 2015;101(2):193–7.CrossRefPubMed Tierney M, Fraser A, Kennedy N. Criterion validity of the international physical activity questionnaire short form (IPAQ-SF) for use in patients with rheumatoid arthritis: comparison with the SenseWear Armband. Physiotherapy. 2015;101(2):193–7.CrossRefPubMed
12.
go back to reference Siebeling L, Wiebers S, Beem L, Puhan MA, Ter Riet G. Validity and reproducibility of a physical activity questionnaire for older adults: questionnaire versus accelerometer for assessing physical activity in older adults. Clin Epidemiol. 2012;4:171–80.CrossRefPubMedCentralPubMed Siebeling L, Wiebers S, Beem L, Puhan MA, Ter Riet G. Validity and reproducibility of a physical activity questionnaire for older adults: questionnaire versus accelerometer for assessing physical activity in older adults. Clin Epidemiol. 2012;4:171–80.CrossRefPubMedCentralPubMed
13.
go back to reference Ramirez-Marrero FA, Rivera-Brown AM, Nazario CM, Rodriguez-Orengo JF, Smit E, Smith BA. Self-reported physical activity in Hispanic adults living with HIV: comparison with accelerometer and pedometer. J Assoc Nurses AIDS Care. 2008;19(4):283–94.CrossRefPubMed Ramirez-Marrero FA, Rivera-Brown AM, Nazario CM, Rodriguez-Orengo JF, Smit E, Smith BA. Self-reported physical activity in Hispanic adults living with HIV: comparison with accelerometer and pedometer. J Assoc Nurses AIDS Care. 2008;19(4):283–94.CrossRefPubMed
14.
go back to reference Jaggers JR, Prasad VK, Dudgeon WD, Blair SN, Sui X, Burgess S, et al. Associations between physical activity and sedentary time on components of metabolic syndrome among adults with HIV. AIDS Care. 2014;26(11):1387–92.CrossRefPubMedCentralPubMed Jaggers JR, Prasad VK, Dudgeon WD, Blair SN, Sui X, Burgess S, et al. Associations between physical activity and sedentary time on components of metabolic syndrome among adults with HIV. AIDS Care. 2014;26(11):1387–92.CrossRefPubMedCentralPubMed
15.
go back to reference Bopp CM, Phillips KD, Fulk LJ, Dudgeon WD, Sowell R, Hand GA. Physical activity and immunity in HIV-infected individuals. AIDS Care. 2004;16(3):387–93.CrossRefPubMed Bopp CM, Phillips KD, Fulk LJ, Dudgeon WD, Sowell R, Hand GA. Physical activity and immunity in HIV-infected individuals. AIDS Care. 2004;16(3):387–93.CrossRefPubMed
16.
go back to reference Smit E, Crespo CJ, Semba RD, Jaworowicz D, Vlahov D, Ricketts EP, et al. Physical activity in a cohort of HIV-positive and HIV-negative injection drug users. AIDS Care. 2006;18(8):1040–5.CrossRefPubMed Smit E, Crespo CJ, Semba RD, Jaworowicz D, Vlahov D, Ricketts EP, et al. Physical activity in a cohort of HIV-positive and HIV-negative injection drug users. AIDS Care. 2006;18(8):1040–5.CrossRefPubMed
17.
go back to reference Mohammed SS, Aghdassi E, Salit IE, Avand G, Sherman M, Guindi M, et al. HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients. J Acquir Immune Defic Syndr. 2007;45(4):432–8.CrossRefPubMed Mohammed SS, Aghdassi E, Salit IE, Avand G, Sherman M, Guindi M, et al. HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients. J Acquir Immune Defic Syndr. 2007;45(4):432–8.CrossRefPubMed
18.
go back to reference Fillipas S, Bowtell-Harris CA, Oldmeadow LB, Cicuttini F, Holland AE, Cherry CL. Physical activity uptake in patients with HIV: who does how much? Int J STD AIDS. 2008;19(8):514–8.CrossRefPubMed Fillipas S, Bowtell-Harris CA, Oldmeadow LB, Cicuttini F, Holland AE, Cherry CL. Physical activity uptake in patients with HIV: who does how much? Int J STD AIDS. 2008;19(8):514–8.CrossRefPubMed
19.
go back to reference Jacobson DL, Tang AM, Spiegelman D, Thomas AM, Skinner S, Gorbach SL, et al. Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey). J Acquir Immune Defic Syndr. 2006;43(4):458–66.CrossRefPubMed Jacobson DL, Tang AM, Spiegelman D, Thomas AM, Skinner S, Gorbach SL, et al. Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey). J Acquir Immune Defic Syndr. 2006;43(4):458–66.CrossRefPubMed
20.
go back to reference Mustafa T, Sy FS, Macera CA, Thompson SJ, Jackson KL, Selassie A, et al. Association between exercise and HIV disease progression in a cohort of homosexual men. Ann Epidemiol. 1999;9(2):127–31.CrossRefPubMed Mustafa T, Sy FS, Macera CA, Thompson SJ, Jackson KL, Selassie A, et al. Association between exercise and HIV disease progression in a cohort of homosexual men. Ann Epidemiol. 1999;9(2):127–31.CrossRefPubMed
21.
go back to reference Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.CrossRefPubMed Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.CrossRefPubMed
22.
go back to reference Colley R, Connor Gorber S, Tremblay MS. Quality control and data reduction procedures for accelerometry-derived measures of physical activity. Health Rep. 2010;21(1):63–9.PubMed Colley R, Connor Gorber S, Tremblay MS. Quality control and data reduction procedures for accelerometry-derived measures of physical activity. Health Rep. 2010;21(1):63–9.PubMed
23.
go back to reference Tudor-Locke C, Johnson WD, Katzmarzyk PT. U.S. population profile of time-stamped accelerometer outputs: impact of wear time. J Phys Act Health. 2011;8(5):693–8.CrossRefPubMed Tudor-Locke C, Johnson WD, Katzmarzyk PT. U.S. population profile of time-stamped accelerometer outputs: impact of wear time. J Phys Act Health. 2011;8(5):693–8.CrossRefPubMed
24.
go back to reference Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, et al. 2011 Compendium of physical activities: a second update of codes and MET values. Med Sci Sport Exerc. 2011;43(8):1575–81.CrossRef Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, et al. 2011 Compendium of physical activities: a second update of codes and MET values. Med Sci Sport Exerc. 2011;43(8):1575–81.CrossRef
25.
go back to reference Same RV, Feldman DI, Shah N, Martin SS, Al Rifai M, Blaha MJ, et al. Relationship between sedentary behavior and cardiovascular risk. Curr Cardiol Rep. 2016;18(1):6.CrossRefPubMed Same RV, Feldman DI, Shah N, Martin SS, Al Rifai M, Blaha MJ, et al. Relationship between sedentary behavior and cardiovascular risk. Curr Cardiol Rep. 2016;18(1):6.CrossRefPubMed
26.
go back to reference Greer AE, Sui X, Maslow AL, Greer BK, Blair SN. The effects of sedentary behavior on metabolic syndrome independent of physical activity and cardiorespiratory fitness. J Phys Act Health. 2015;12(1):68–73.CrossRefPubMed Greer AE, Sui X, Maslow AL, Greer BK, Blair SN. The effects of sedentary behavior on metabolic syndrome independent of physical activity and cardiorespiratory fitness. J Phys Act Health. 2015;12(1):68–73.CrossRefPubMed
27.
go back to reference Zhou Y, Zhao H, Peng C. Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Ann Epidemiol. 2015;25(9):687–97.CrossRefPubMed Zhou Y, Zhao H, Peng C. Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Ann Epidemiol. 2015;25(9):687–97.CrossRefPubMed
28.
go back to reference Edwardson CL, Gorely T, Davies MJ, Gray LJ, Khunti K, Wilmot EG, et al. Association of sedentary behaviour with metabolic syndrome: a meta-analysis. PLoS ONE. 2012;7(4):e34916.CrossRefPubMedCentralPubMed Edwardson CL, Gorely T, Davies MJ, Gray LJ, Khunti K, Wilmot EG, et al. Association of sedentary behaviour with metabolic syndrome: a meta-analysis. PLoS ONE. 2012;7(4):e34916.CrossRefPubMedCentralPubMed
29.
go back to reference Hallal PC, Andersen LB, Bull FC, Guthold R, Haskell W, Ekelund U, et al. Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet. 2012;380(9838):247–57.CrossRefPubMed Hallal PC, Andersen LB, Bull FC, Guthold R, Haskell W, Ekelund U, et al. Global physical activity levels: surveillance progress, pitfalls, and prospects. Lancet. 2012;380(9838):247–57.CrossRefPubMed
30.
go back to reference Rowan SE, Burman WJ, Johnson SC, Connick E, Reirden D, Daniloff E, et al. Engagement-in-care during the first 5 years after HIV diagnosis: data from a cohort of newly HIV-diagnosed individuals in a large US city. AIDS Patient Care STDs. 2014;28(9):475–82.CrossRefPubMedCentralPubMed Rowan SE, Burman WJ, Johnson SC, Connick E, Reirden D, Daniloff E, et al. Engagement-in-care during the first 5 years after HIV diagnosis: data from a cohort of newly HIV-diagnosed individuals in a large US city. AIDS Patient Care STDs. 2014;28(9):475–82.CrossRefPubMedCentralPubMed
31.
go back to reference Villegas R, Creagh D, Hinchion R, O’Halloran D, Perry IJ. Prevalence and lifestyle determinants of the metabolic syndrome. Ir Med J. 2004;97(10):300–3.PubMed Villegas R, Creagh D, Hinchion R, O’Halloran D, Perry IJ. Prevalence and lifestyle determinants of the metabolic syndrome. Ir Med J. 2004;97(10):300–3.PubMed
32.
go back to reference Gavrila A, Tsiodras S, Doweiko J, Nagy GS, Brodovicz K, Hsu W, et al. Exercise and vitamin E intake are independently associated with metabolic abnormalities in human immunodeficiency virus-positive subjects: a cross-sectional study. Clin Infect Dis. 2003;36(12):1593–601.CrossRefPubMed Gavrila A, Tsiodras S, Doweiko J, Nagy GS, Brodovicz K, Hsu W, et al. Exercise and vitamin E intake are independently associated with metabolic abnormalities in human immunodeficiency virus-positive subjects: a cross-sectional study. Clin Infect Dis. 2003;36(12):1593–601.CrossRefPubMed
33.
go back to reference Shah M, Tierney K, Adams-Huet B, Boonyavarakul A, Jacob K, Quittner C, et al. The role of diet, exercise and smoking in dyslipidaemia in HIV-infected patients with lipodystrophy. HIV Med. 2005;6(4):291–8.CrossRefPubMed Shah M, Tierney K, Adams-Huet B, Boonyavarakul A, Jacob K, Quittner C, et al. The role of diet, exercise and smoking in dyslipidaemia in HIV-infected patients with lipodystrophy. HIV Med. 2005;6(4):291–8.CrossRefPubMed
34.
go back to reference Jones SP, Doran DA, Leatt PB, Maher B, Pirmohamed M. Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy. AIDS. 2001;15(15):2049–51.CrossRefPubMed Jones SP, Doran DA, Leatt PB, Maher B, Pirmohamed M. Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy. AIDS. 2001;15(15):2049–51.CrossRefPubMed
35.
go back to reference Thoni GJ, Fedou C, Brun JF, Fabre J, Renard E, Reynes J, et al. Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemia. Diabetes Metab. 2002;28(5):397–404.PubMed Thoni GJ, Fedou C, Brun JF, Fabre J, Renard E, Reynes J, et al. Reduction of fat accumulation and lipid disorders by individualized light aerobic training in human immunodeficiency virus infected patients with lipodystrophy and/or dyslipidemia. Diabetes Metab. 2002;28(5):397–404.PubMed
36.
go back to reference Yarasheski KE, Tebas P, Stanerson B, Claxton S, Marin D, Bae K, et al. Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy. J Appl Physiol (1985). 2001;90(1):133–8.CrossRef Yarasheski KE, Tebas P, Stanerson B, Claxton S, Marin D, Bae K, et al. Resistance exercise training reduces hypertriglyceridemia in HIV-infected men treated with antiviral therapy. J Appl Physiol (1985). 2001;90(1):133–8.CrossRef
Metadata
Title
Physical Activity is Associated with Metabolic Health in Men Living with HIV
Authors
Cuisle Forde
Aisling Loy
Siobhan O’Dea
Fiona Mulcahy
John Gormley
Caroline Daly
Publication date
01-06-2018
Publisher
Springer US
Published in
AIDS and Behavior / Issue 6/2018
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-017-1715-8

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