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AIDS and Behavior
Published in: AIDS and Behavior 7/2016

01-07-2016 | Original Paper

The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of The iPrEx OLE Study

Authors: Megha L. Mehrotra, David V. Glidden, Vanessa McMahan, K. Rivet Amico, Sybil Hosek, Patricia Defechereux, Kenneth H. Mayer, Valdilea G. Veloso, Linda-Gail Bekker, Vivian I. Avelino-Silva, Mauro Schechter, Robert M. Grant

Published in: AIDS and Behavior | Issue 7/2016

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Abstract

We assessed the role of depressive symptoms on adherence to daily oral FTC/TDF for HIV PrEP in cisgender men who have sex with men (MSM) and transgender women who have sex with men (TGW) using data from the iPrEx OLE study. A marginal structural logistic regression model was used to estimate the effect of time-varying CES-D scores on having protective levels of drug concentration, adjusting for confounding by sexual practices over time, prior adherence, and baseline demographic characteristics. We found a non-monotonic relationship between CES-D score and odds of protective FTC/TDF levels in MSM. We found evidence that the effect of depression on adherence varied between MSM and TGW, and that depressive symptoms did not contribute greatly to decreased adherence on a population scale. We recommend that depressive symptoms not preclude the prescription of PrEP, and that MSM and TGW be studied separately.
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Metadata
Title
The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of The iPrEx OLE Study
Authors
Megha L. Mehrotra
David V. Glidden
Vanessa McMahan
K. Rivet Amico
Sybil Hosek
Patricia Defechereux
Kenneth H. Mayer
Valdilea G. Veloso
Linda-Gail Bekker
Vivian I. Avelino-Silva
Mauro Schechter
Robert M. Grant
Publication date
01-07-2016
Publisher
Springer US
Published in
AIDS and Behavior / Issue 7/2016
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-016-1415-9

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