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01-07-2016 | Original Paper

Early Adopters: Correlates of HIV Chemoprophylaxis Use in Recent Online Samples of US Men Who Have Sex with Men

Authors: Kenneth H. Mayer, Catherine E. Oldenburg, David S. Novak, Steven A. Elsesser, Douglas S. Krakower, Matthew J. Mimiaga

Published in: AIDS and Behavior | Issue 7/2016

Abstract

To date, little data on pre-exposure prophylaxis (PrEP) users outside of the clinical trial setting are available. A repeated cross-sectional survey of one of the largest social and sexual networking websites for men who have sex with men (MSM) in the United States was conducted in August 2013 (Wave 1) and January 2014 (Wave 2). Multivariable logistic regression models were used to assess factors associated with having heard of and having taken post-exposure prophylaxis (PEP) and PrEP in Wave 1 (N = 4043) and Wave 2 (N = 2737) separately. In Wave 1, 147 (3.6 %) and 61 (1.5 %) reported using PEP and PrEP, respectively, compared to 119 (4.4 %) and 62 (2.3 %) in Wave 2. Higher-risk sexual behaviors were associated with having taken PEP and PrEP, and previous PEP use was associated with having taken PrEP. Understanding factors that are associated with early use of PrEP may help inform wider utilization of PrEP by at risk MSM.

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Prejean J, Song R, Hernandez A, et al. Estimated HIV incidence in the United States, 2006–2009. PLoS One. 2011;6:e17502.CrossRefPubMedPubMedCentral

Baral S, Logie CH, Grosso A, Wirtz AL, Beyrer C. Modified social ecological model: a tool to guide the assessment of the risks and risk contexts of HIV epidemics. BMC Public Health. 2013;13:482.CrossRefPubMedPubMedCentral

Mayer KH, Wheeler DP, Bekker LG, et al. Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men. J Acquir Immune Defic Syndr. 2013;63:S161–7.CrossRefPubMedPubMedCentral

Logie CH, Newman PA, Chakrapani V, Shunmugam M. Adapting the minority stress model: associations between gender non-conformity stigma, HIV-related stigma and depression among men who have sex with men in South India. Soc Sci Med. 2012;74:1261–8.CrossRefPubMed

Oldenburg C, Biello KB, Colby D, et al. Stigma related to sex work among men who engage in transactional sex with men in Ho Chi Minh City, Vietnam. Int J Public Health. 2014;59:833–40.CrossRefPubMedPubMedCentral

Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99.CrossRefPubMedPubMedCentral

Thigpen MC, Kebaabetswe PM, Paxton LA, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367:423–34.CrossRefPubMed

Choopanya K, Martin M, Suntharasamai P, et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet. 2013;381:2083–90.CrossRef

Baeten JM, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399–410.CrossRefPubMedPubMedCentral

10.

Smith DK, Grohskopf LA, Black RJ, et al. Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States. MMWR Recomm Rep. 2005;54:1–20.PubMed

11.

Schechter M, do Lago RF, Mendelson AB, et al. Behavioral impact, acceptability, and HIV incidence among homosexual men with access to postexposure chemoprophylaxis for HIV. J Acquir Immune Defic Syndr. 2004;35:519–25.CrossRefPubMed

12.

Oldenburg CE, Biello KB, Colby D, et al. Engagement with peer health educators is associated with willingness to use pre-exposure prophylaxis among male sex workers in Ho Chi Minh City, Vietnam. AIDS Patient Care STDs. 2014;28:109–12.CrossRefPubMedPubMedCentral

13.

Zhang Y, Peng B, She Y, et al. Attitudes toward HIV pre-exposure prophylaxis among men who have sex with men in Western China. AIDS Patient Care STDs. 2013;27:137–41.CrossRefPubMedPubMedCentral

14.

Yang D, Chariyalertsak C, Wongthanee A, et al. Acceptability of pre-exposure prophylaxis among men who have sex with men and transgender women in Northern Thailand. PLoS One. 2013;8:e76650.CrossRefPubMedPubMedCentral

15.

Aghaizu A, Mercey D, Copas A, Johnson AM, Hart G, Nardone A. Who would use PrEP? Factors associated with intention to use among MSM in London: a community survey. Sex Transm Infect. 2012;89:207–11.CrossRefPubMed

16.

Golub SA, Gamarel KE, Rendina HJ, Surace A, Lelutiu-Weinberger CL. From efficacy to effectiveness: facilitators and barriers to PrEP acceptability and motivations for adherence among MSM and transgender women in New York City. AIDS Patient Care STDs. 2013;27:248–54.CrossRefPubMedPubMedCentral

17.

Galea JT, Kinsler JJ, Salazar X, et al. Acceptability of pre-exposure prophylaxis as an HIV prevention strategy: barriers and facilitators to pre-exposure prophylaxis uptake among at-risk Peruvian populations. Int J STD AIDS. 2011;22:256–62.CrossRefPubMedPubMedCentral

18.

Saberi P, Gamarel KE, Neilands TB, et al. Ambiguity, ambivalence, and apprehensions of taking HIV-1 pre-exposure prophylaxis among male couples in San Francisco: a mixed methods study. PLoS One. 2012;7:e50061.CrossRefPubMedPubMedCentral

19.

Galindo GR, Walker JNJ, Hazelton P, et al. Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation. Implement Sci. 2012;7(1):116.CrossRefPubMedPubMedCentral

20.

Jain S, Oldenburg CE, Mimiaga MJ, Mayer KH. Longitudinal trends in HIV non-occupational post-exposure prophylaxis (NPEP) use at a Boston community health center between 1997 and 2013. J Acquir Immune Defic Syndr. 2015;68:97–101.CrossRefPubMedPubMedCentral

21.

Krakower DS, Mimiaga MJ, Rosenberger JG, et al. Limited awareness and low immediate uptake of pre-exposure prophylaxis among men who have sex with men using an internet social networking site. PLoS One. 2012;7:e33119.CrossRefPubMedPubMedCentral

22.

Lorente N, Fugon L, Carrieri MP, et al. Acceptability of an “on-demand” pre-exposure HIV prophylaxis trial among men who have sex with men living in France. AIDS Care. 2012;24(4):468–77. doi:10.1080/09540121.2011.626394.

23.

Peinado J, Lama JR, Galea JT, et al. Acceptability of oral versus rectal HIV preexposure prophylaxis among men who have sex with men and transgender women in Peru. J Int Assoc Provid AIDS Care. 2013;12:278–83.CrossRefPubMed

24.

Young I, Li J, McDaid L. Awareness and willingness to use HIV pre-exposure prophylaxis amongst gay and bisexual men in Scotland: implications for biomedical HIV prevention. PLoS One. 2013;8:e64038.CrossRefPubMedPubMedCentral

25.

Young I, McDaid L. How acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: a review of research on the acceptability of oral pre-exposure prophylaxis and treatment as prevention. AIDS Behav. 2013. doi:10.1007/s10461-013-0560-7.

26.

Van der Elst EM, Mbogua J, Operario D, et al. High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya. AIDS Behav. 2012;17:2162–72.CrossRef

27.

Steyerberg EW. Clinical prediction models: a practical approach to development, validation, and updating. New York: Springer; 2009.CrossRef

28.

Oldenburg CE, Perez-Brumer AG, Hatzenbuehler ML, et al. State-level structural sexual stigma and HIV prevention in a national online sample of HIV-uninfected MSM in the United States. AIDS. 2015;29:837–45.CrossRefPubMedPubMedCentral

29.

Oldenburg CE, Perez-Brumer AG, Reisner SL. Poverty matters: contextualizing the syndemic condition of psychological factors and newly diagnosed HIV infection in the United States. AIDS. 2014;28:2763–9.CrossRefPubMedPubMedCentral

30.

Jain S, Oldenburg CE, Mimiaga MJ, Mayer KH. Subsequent HIV infection among men who have sex with men who used non-occupational post-exposure prophylaxis at a Boston community health center: 1997–2013. AIDS Patient Care STDS. 2015;29(1):20–5. doi:10.1089/apc.2014.0154.CrossRefPubMedPubMedCentral

31.

Cahill S, Singal R, Grasso C, et al. Do ask, do tell: high levels of acceptability by patients of routine collection of sexual orientation and gender identity data in four diverse American Community Health Centers. PLoS One. 2014;9:e107104.CrossRefPubMedPubMedCentral

32.

Mayer KH. Do ask, do tell: clinicians and the U.S. National AIDS strategy. AIDS. 2014;28:1233–5.CrossRefPubMed

33.

US Public Health Service. Preexposure prophylaxis for the prevention of HIV infection in the United States-2014: a clinical practice guideline. Centers for Disease Control and Prevention.

34.

van der Elst EM, Okuku HS, Nakamya P, et al. Is audio computer-assisted self-interview (ACASI) useful in risk behaviour assessment of female and male sex workers, Mombasa, Kenya? PLoS One. 2009;4:e5340.CrossRefPubMedPubMedCentral

35.

Beauclair R, Meng F, Deprez N, et al. Evaluating audio computer assisted self-interviews in urban south African communities: evidence for good suitability and reduced social desirability bias of a cross-sectional survey on sexual behaviour. BMC Med Res Methodol. 2013;13(1):11.CrossRefPubMedPubMedCentral

Title: Early Adopters: Correlates of HIV Chemoprophylaxis Use in Recent Online Samples of US Men Who Have Sex with Men
Authors: Kenneth H. Mayer
Catherine E. Oldenburg
David S. Novak
Steven A. Elsesser
Douglas S. Krakower
Matthew J. Mimiaga
Publication date: 01-07-2016
Publisher: Springer US
Published in: AIDS and Behavior / Issue 7/2016
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-015-1237-1

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