Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
AIDS and Behavior
Published in: AIDS and Behavior 2/2015

01-06-2015 | Original Paper

Development and Pilot Testing of Daily Interactive Voice Response (IVR) Calls to Support Antiretroviral Adherence in India: A Mixed-Methods Pilot Study

Authors: Dallas Swendeman, Smarajit Jana, Protim Ray, Deborah Mindry, Madhushree Das, Bhumi Bhakta

Published in: AIDS and Behavior | Special Issue 2/2015

Login to get access

Abstract

This two-phase pilot study aimed to design, pilot, and refine an automated interactive voice response (IVR) intervention to support antiretroviral adherence for people living with HIV (PLH), in Kolkata, India. Mixed-methods formative research included a community advisory board for IVR message development, 1-month pre-post pilot, post-pilot focus groups, and further message development. Two IVR calls are made daily, timed to patients’ dosing schedules, with brief messages (<1-min) on strategies for self-management of three domains: medical (adherence, symptoms, co-infections), mental health (social support, stress, positive cognitions), and nutrition and hygiene (per PLH preferences). Three ART appointment reminders are also sent each month. One-month pilot results (n = 46, 80 % women, 60 % sex workers) found significant increases in self-reported ART adherence, both within past three days (p = 0.05) and time since missed last dose (p = 0.015). Depression was common. Messaging content and assessment domains were expanded for testing in a randomized trial currently underway.
Literature
1.
2.
Bangsberg DR. Less than 95 % adherence to nonnucleoside reverse-transcriptase inhibitor therapy can lead to viral suppression. Clin Infect Dis. 2006;43(7):939–41.PubMedCrossRef
3.
Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Arch Intern Med. 1998;158(16):1789–95 sd.PubMedCrossRef
4.
Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, Wu AW. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care. 2000;12(3):255–66.PubMedCrossRef
5.
Coomes CM, Lewis MA, Uhrig JD, Furberg RD, Harris JL, Bann CM. Beyond reminders: a conceptual framework for using short message service to promote prevention and improve healthcare quality and clinical outcomes for people living with HIV. AIDS Care. 2012;24(3):348–57 Epub 2011 Sep 21.PubMedCrossRef
6.
Crepaz N, Tungol-Ashmon MV, Higa DH, Vosburgh W, Mullins MM, Barham T,… Lyles CM. A systematic review of interventions for reducing HIV risk behaviors among people living with HIV in the United States, 1988–2012. AIDS. 2014;28(5): 633–56.
7.
Finitsis DJ, Pellowski JA, Johnson BT. Text message intervention designs to promote adherence to antiretroviral therapy (ART): a meta-analysis of randomized controlled trials. PLoS One. 2014;9(2):e88166.PubMedCentralPubMedCrossRef
8.
Fisher JD, Fisher WA, Amico KR, Harman JJ. An information-motivation-behavioral skills model of adherence to antiretroviral therapy. Health Psychol. 2006;25(4):462.
9.
Garrett JJ. Elements of user experience, the: user-centered design for the web and beyond. London: Pearson Education; 2010.
10.
Genberg BL, Wilson IB, Bangsberg DR, Arnsten J, Goggin K, Remien RH,… MACH14 Investigators. Patterns of antiretroviral therapy adherence and impact on HIV RNA among patients in North America. AIDS (London, England). 2012;26(11):1415.
11.
Gentry S, van Velthoven MH, Tudor Car L, Car J. Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection. Cochrane Database System Rev. 2013;5:CD009189.
12.
Hardy H, Kumar V, Doros G, Farmer E, Drainoni ML, Rybin D,… Skolnik PR. Randomized controlled trial of a personalized cellular phone reminder system to enhance adherence to antiretroviral therapy. AIDS Patient Care St. 2011;25(3):153–61.
13.
Herrmann C. International experiences with the Hospital Anxiety and Depression Scale—a review of validation data and clinical results. J Psychosom Res. 1997;42(1):17–41.PubMedCrossRef
14.
Johnson MO, Charlebois E, Morin SF, Remien RH, Chesney MA, The NIMH Healthy Living Project Team. Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: The Healthy Living Project randomized controlled study. J Acquir Immune Defic Syndr. 2007;46(5):574–80.PubMedCentralPubMedCrossRef
15.
Joshi A, Rane M, Roy D, Emmadi N, Srinivasan P, Kumarasamy N,… Rutten R. Supporting treatment of people living with HIV/AIDS in resource limited settings with IVRs. In Proceedings of the 32nd annual ACM conference on Human factors in computing systems. 2014; pp. 1595–1604. ACM.
16.
Kalichman SC, Kalichman MO, Cherry C, Swetzes C, Amaral CM, White D, et al. Brief behavioural self-regulation counselling for HIV treatment adherence delivered by cell phone: an initial test of concept trial. AIDS Patient Care and STDs. 2011;25(5):303–10.PubMedCentralPubMedCrossRef
17.
Langebeek N, Gisolf EH, Reiss P, Vervoort SC, Thóra B, Richter C,… Nieuwkerk PT. Predictors and correlates of adherence to combination antiretroviral therapy (cART) for chronic HIV infection: a meta-analysis. BMC Med. 2014;12(1):142.
18.
Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH,… Plummer FA. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. The Lancet. 2010;376(9755):1838–1845.
19.
Malta M, Strathdee SA, Magnanini MM, Bastos FI. Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a systematic review. Addiction. 2008;103(8):1242–57.PubMedCrossRef
20.
Mbuagbaw L, Thabane L, Ongolo-Zogo P, Lester RT, Mills E J, Smieja M,… Kouanfack C. The Cameroon mobile phone SMS (CAMPS) trial: a randomized trial of text messaging versus usual care for adherence to antiretroviral therapy. PLoS One. 2012;7(12):e46909.
21.
Mbuagbaw L, van der Kop ML, Lester RT, Thirumurthy H, Pop-Eleches C, Ye C,… Thabane L. Mobile phone text messages for improving adherence to antiretroviral therapy (ART): an individual patient data meta-analysis of randomised trials. BMJ Open. 2013;3(12):e003950.
22.
Miles MB, Huberman AM. An expanded sourcebook: qualitative data analysis. 2nd ed. Thousand Oaks: Sage; 1994.
23.
Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S,… Bangsberg DR. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296(6):679–690
24.
Mhaskar R, Alandikar V, Emmanuel P, Djulbegovic B, Patel S, Patel A,… Kumar A. Adherence to antiretroviral therapy in India: a systematic review and meta-analysis. Indian J Community Med. 2013;38(2):74.
25.
26.
27.
Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses. 2004;20(10):1053–6.PubMedCrossRef
28.
Ortego C, Huedo-Medina TB, Llorca J, Sevilla L, Santos P, Rodríguez E,… Vejo J. Adherence to highly active antiretroviral therapy (HAART): a meta-analysis. AIDS Behav. 2011;15(7): 1381–1396.
29.
Parienti JJ, Das-Douglas M, Massari V, Guzman D, Deeks SG, Verdon R, Bangsberg DR. Not all missed doses are the same: sustained NNRTI treatment interruptions predict HIV rebound at low-to-moderate adherence levels. PLoS One. 2008;3(7):e2783.PubMedCentralPubMedCrossRef
30.
Pop-Eleches C, Thirumurthy H, Habyarimana JP, Zivin JG, Goldstein MP, De Walque D,… Bangsberg DR. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. AIDS (London, England). 2011;25(6):825.
31.
Reynolds NR, Testa MA, Su M, Chesney MA, Neidig JF, Frank I, et al. Telephone support to improve antiretroviral medications adherence: a multisite randomized controlled trial. J Acquir Immune Defic Syndr. 2008;47(1):62–8.PubMedCrossRef
32.
Rodrigues R, Shet A, Antony J, Sidney K, Arumugam K, Krishnamurthy S,… DeCosta A. Supporting adherence to antiretroviral therapy with mobile phone reminders: results from a cohort in South India. PloS One. 2012;7(8):e40723.
33.
Rotheram-Borus MJ, Swendeman D, Chorpita BF. Disruptive innovations for designing and diffusing evidence-based interventions. Am Psychol. 2012;67(6):463–76.
34.
Rotheram-Borus MJ, Swendeman D, Comulada WS, Weiss RE, Lee M, Lightfoot M. Prevention for substance-using HIV-positive young people: telephone and in-person delivery. J Acquir Immune Defic Syndr. 2004;37(Suppl 2):S68.PubMedCentralPubMedCrossRef
35.
Rotheram-Borus MJ, Swendeman D, Flannery D, Rice E, Adamson DM, Ingram B. Common factors in effective HIV prevention programs. AIDS Behav. 2009;13(3):399–408.
36.
Ryan RM, Deci EL. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. Am Psychol. 2000;55(1):68.PubMedCrossRef
37.
Rueda S, Park-Wyllie LY, Bayoumi AM, Tynan AM, Antoniou TA, Rourke SB, Glazier RH. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. Cochrane Database Syst Rev. 2006;3(3):CD001442.PubMed
38.
39.
SAS Institute Inc, Cary, N.C: SAS Institute Inc.
40.
Shilton, Katie, et al. “Participatory design of sensing networks: strengths and challenges.” Proceedings of the Tenth Anniversary Conference on Participatory Design 2008. Indiana University, 2008.
41.
Simoni JM, Amico KR, Smith L, Nelson K. Antiretroviral adherence interventions: translating research findings to the real world clinic. Curr HIV/AIDS Rep. 2010;7(1):44–51.PubMedCentralPubMedCrossRef
42.
Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr. 2006;43(01):S23.PubMedCentralPubMedCrossRef
43.
44.
Swendeman D, Ingram BL, Rotheram-Borus MJ. Common elements in self-management of HIV and other chronic illnesses: an integrative framework. AIDS Care. 2009;21(10):1321–34.PubMedCentralPubMedCrossRef
45.
46.
Thomas BC, Devi N, Sarita GP, Rita K, Ramdas K, Hussain BM, Rejnish R, Pandey M. Reliability & validity of the Malayalam hospital anxiety & depression scale (HADS) in cancer patients. Indian J Med Res. 2005;122:395–9.PubMed
47.
48.
Vervloet M, Linn AJ, van Weert JC, De Bakker DH, Bouvy ML, Van Dijk L. The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature. J Am Med Inform Assoc. 2012;19(5):696–704.
49.
Wise J, Operario D. Use of electronic reminder devices to improve adherence to antiretroviral therapy: a systematic review. AIDS Patient Care STDs. 2008;22(6):495–504.PubMedCrossRef
50.
Whittaker R, Merry S, Stasiak K, McDowell H, Doherty I, Shepherd M, … Rodgers A. MEMO—A mobile phone depression prevention intervention for adolescents: development process and post-program findings on acceptability from a randomized controlled trial. J Med Internet Res. 2012;14(1):e13. doi:10.​2196/​jmir.​1857.
Metadata
Title
Development and Pilot Testing of Daily Interactive Voice Response (IVR) Calls to Support Antiretroviral Adherence in India: A Mixed-Methods Pilot Study
Authors
Dallas Swendeman
Smarajit Jana
Protim Ray
Deborah Mindry
Madhushree Das
Bhumi Bhakta
Publication date
01-06-2015
Publisher
Springer US
Published in
AIDS and Behavior / Issue Special Issue 2/2015
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0983-9

Other articles of this Special Issue 2/2015

AIDS and Behavior 2/2015 Go to the issue

Original Paper

A Remotely-Delivered CBT and Contingency Management Therapy for Substance Using People with HIV

Original Paper

Antiretroviral Therapy Adherence and Use of an Electronic Shared Medical Record Among People Living with HIV

Original Paper

Feasibility of Recruiting Peer Educators to Promote HIV Testing Using Facebook Among Men Who have Sex with Men in Peru

Original Paper

Exposure to Theory-Driven Text Messages is Associated with HIV Risk Reduction Among Methamphetamine-Using Men Who have Sex with Men

Original Paper

Social Media Use and High-Risk Sexual Behavior Among Black Men Who Have Sex with Men: A Three-City Study

Guest Editorial

Re-shaping HIV Interventions with Technology
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits