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AIDS and Behavior
Published in: AIDS and Behavior 3/2015

01-03-2015 | Original Paper

Individualized Texting for Adherence Building (iTAB): Improving Antiretroviral Dose Timing Among HIV-Infected Persons with Co-occurring Bipolar Disorder

Authors: David J. Moore, Amelia Poquette, Kaitlin B. Casaletto, Ben Gouaux, Jessica L. Montoya, Carolina Posada, Alexandra S. Rooney, Jayraan Badiee, Reena Deutsch, Scott L. Letendre, Colin A. Depp, Igor Grant, J. Hampton Atkinson, The HIV Neurobehavioral Research Program (HNRP) Group

Published in: AIDS and Behavior | Issue 3/2015

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Abstract

HIV+ persons with co-occurring bipolar disorder (HIV+/BD+) have elevated rates of medication nonadherence. We conducted a 30-day randomized controlled trial of a two-way, text messaging system, iTAB (n = 25), compared to an active comparison (CTRL) (n = 25) to improve antiretroviral (ARV) and psychotropic (PSY) adherence and dose timing. Both groups received medication adherence psychoeducation and daily texts assessing mood. The iTAB group additionally received personalized medication reminder texts. Participants responded to over 90 % of the mood and adherence text messages. Mean adherence, as assessed via electronic monitoring caps, was high and comparable between groups for both ARV (iTAB 86.2 % vs. CTRL 84.8 %; p = 0.95, Cliff’s d = 0.01) and PSY (iTAB 78.9 % vs. CTRL 77.3 %; p = 0.43, Cliff’s d = −0.13) medications. However, iTAB participants took ARVs significantly closer to their intended dosing time than CTRL participants (iTAB: 27.8 vs. CTRL: 77.0 min from target time; p = 0.02, Cliff’s d = 0.37). There was no group difference on PSY dose timing. Text messaging interventions may represent a low-burden approach to improving timeliness of medication-taking behaviors among difficult-to-treat populations. The benefits of improved dose timing for long-term medication adherence require additional investigation.
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Metadata
Title
Individualized Texting for Adherence Building (iTAB): Improving Antiretroviral Dose Timing Among HIV-Infected Persons with Co-occurring Bipolar Disorder
Authors
David J. Moore
Amelia Poquette
Kaitlin B. Casaletto
Ben Gouaux
Jessica L. Montoya
Carolina Posada
Alexandra S. Rooney
Jayraan Badiee
Reena Deutsch
Scott L. Letendre
Colin A. Depp
Igor Grant
J. Hampton Atkinson
The HIV Neurobehavioral Research Program (HNRP) Group
Publication date
01-03-2015
Publisher
Springer US
Published in
AIDS and Behavior / Issue 3/2015
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0971-0

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