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01-12-2014 | Brief Report

The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Authors: Jane M. Simoni, David Huh, Yan Wang, Ira B. Wilson, Nancy R. Reynolds, Robert H. Remien, Kathy Goggin, Robert Gross, Marc I. Rosen, Neil Schneiderman, Julia Arnsten, Carol E. Golin, Judith A. Erlen, David R. Bangsberg, Honghu Liu

Published in: AIDS and Behavior | Issue 12/2014

Abstract

In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher’s aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.

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Title: The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study
Authors: Jane M. Simoni
David Huh
Yan Wang
Ira B. Wilson
Nancy R. Reynolds
Robert H. Remien
Kathy Goggin
Robert Gross
Marc I. Rosen
Neil Schneiderman
Julia Arnsten
Carol E. Golin
Judith A. Erlen
David R. Bangsberg
Honghu Liu
Publication date: 01-12-2014
Publisher: Springer US
Published in: AIDS and Behavior / Issue 12/2014
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-014-0905-x

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The Validity of Self-Reported Medication Adherence as an Outcome in Clinical Trials of Adherence-Promotion Interventions: Findings from the MACH14 Study

Abstract

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Abstract

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