Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
AIDS and Behavior
Published in: AIDS and Behavior 8/2013

01-10-2013 | Original Paper

A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study

Authors: Jane M. Simoni, John S. Wiebe, John A. Sauceda, David Huh, Giselle Sanchez, Virginia Longoria, C. Andres Bedoya, Steven A. Safren

Published in: AIDS and Behavior | Issue 8/2013

Login to get access

Abstract

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of “moderate” to “large” size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = −3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.
Literature
1.
2.
del Rio C. Latinos and HIV care in the southeastern United States: new challenges complicating longstanding problems. Clin Infect Dis. 2011;53(5):488–9.PubMedCrossRef
3.
Sanchez MA, Lemp GF, Magis-Rodríguez C, Bravo-García E, Carter S, Ruiz JD. The epidemiology of HIV among Mexican migrants and recent immigrants in California and Mexico. J Acquir Immune Defic Syndr. 2004;37(Suppl 4):S204–14.PubMedCrossRef
4.
Santos G, Puga AM, Medina C. HAART, adherence, and cultural issues in the US Latino community. AIDS Read. 2004;14(Suppl 10):S26–9.PubMed
5.
Murphy DA, Roberts KJ, Hoffman D, Molina A, Lu MC. Barriers and successful strategies to antiretroviral adherence among HIV-infected monolingual Spanish-speaking patients. AIDS Care. 2003;15(2):217–30.PubMedCrossRef
6.
Simoni JM, Amico KR, Pearson CR, Malow R. Strategies for promoting adherence to antiretroviral therapy: a review of the literature. Curr Infect Dis Rep. 2008;10(6):515–21.PubMedCrossRef
7.
Simoni JM, Amico KR, Smith L, Nelson K. Antiretroviral adherence interventions: translating research findings to the real world clinic. Curr HIV/AIDS Rep. 2010;7(1):44–51.PubMedCrossRef
8.
Simoni JM, Pearson CR, Pantalone DW, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr. 2006;43(Suppl 1):S23–35.PubMedCrossRef
9.
van Servellen G, Nyamathi A, Carpio F, et al. Effects of a treatment adherence enhancement program on health literacy, patient-provider relationships, and adherence to HAART among low-income HIV-positive Spanish-speaking Latinos. AIDS Patient Care STDS. 2005;19(11):745–59.PubMedCrossRef
10.
Ciesla JA, Roberts JE. Meta-analysis of the relationship between HIV infection and risk for depressive disorders. Am J Psychiatry. 2001;158(5):725–30.PubMedCrossRef
11.
Safren SA, Otto MW, Worth JL, et al. Two strategies to increase adherence to HIV antiretroviral medication: life-steps and medication monitoring. Behav Res Ther. 2001;39(10):1151–62.PubMedCrossRef
12.
Longoria V, Wiebe JS, Jones A. A nurse-based disease management model of HIV/AIDS care on the U.S./Mexico Border. In: Curiel H, editor. Innovative strategies for HIV/AIDS prevention & care along the U.S./Mexico Border. Washington: HRSA; 2007.
13.
Gonzalez JS, Batchelder AW, Psaros C, Safren SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58(2):181–7.PubMed
14.
Sherr L, Clucas C, Harding R, Sibley E, Catalan J. HIV and depression—a systematic review of interventions. Psychol Health Med. 2011;16(5):493–527.PubMedCrossRef
15.
16.
Wagner GJ, Goggin K, Remien RH, et al. A closer look at depression and its relationship to HIV antiretroviral adherence. Ann Behav Med. 2011;42(3):352–60.PubMedCrossRef
17.
Safren SA, Radomsky AS, Otto MW, Salomon E. Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy. Psychosomatics. 2002;43(6):478–85.PubMedCrossRef
18.
Kelly JA, Murphy DA, Bahr GR, et al. Outcome of cognitive-behavioral and support group brief therapies for depressed, HIV-infected persons. Am J Psychiatry. 1993;150(11):1679–86.PubMed
19.
Mulder CL, Emmelkamp PM, Antoni MH, Mulder JW, Sandfort TG, de Vries MJ. Cognitive-behavioral and experiential group psychotherapy for HIV-infected homosexual men: a comparative study. Psychosom Med. 1994;56(5):423–31.PubMed
20.
Thomason BT, Bachanas PJ, Campos PE. Cognitive behavioral interventions with persons affected by HIV/AIDS. Cogn Behav Pract. 1996;3:417–42.CrossRef
21.
Balfour L, Kowal J, Silverman A, et al. A randomized controlled psycho-education intervention trial: improving psychological readiness for successful HIV medication adherence and reducing depression before initiating HAART. AIDS Care. 2006;18(7):830–8.PubMedCrossRef
22.
Laperriere A, Ironson GH, Antoni MH, et al. Decreased depression up to one year following CBSM+ intervention in depressed women with AIDS: the smart/EST women’s project. J Health Psychol. 2005;10(2):223–31.PubMedCrossRef
23.
Olatunji BO, Mimiaga MJ, O’Cleirigh C, Safren SA. Review of treatment studies of depression in HIV. Top HIV Med. 2006;14(3):112–24.PubMed
24.
Yun LWH, Maravi M, Kobayashi JS, Barton PL, Davidson AJ. Antidepressant treatment improves adherence to antiretroviral therapy among depressed HIV-infected patients. J Acquir Immune Defic Syndr. 2005;38(4):432–8.PubMedCrossRef
25.
Safren SA, Gonzalez JS, Soroudi N. Coping with chronic illness: cognitive behavioral therapy for adherence and depression in individuals with chronic illness, client workbook. New York: Oxford University Press; 2007.
26.
Safren SA, Gonzalez JS, Soroudi N. Coping with chronic illness: cognitive behavioral therapy for adherence and depression in individuals with chronic illness, therapist guide. New York: Oxford University Press; 2007.
27.
Nezu AM, Nezu CM, Friedman SH, Faddis S, Houts PS. Helping cancer patients cope: a problem-solving approach. Washington: American Psychological Association; 1998.CrossRef
28.
Nezu A, Nezu C, Friedman SH, Houts P, Faddis S. Project Genesis: application of problem-solving therapy to individuals with cancer. Behav Ther. 1997;9:155–8.
29.
Safren S, Otto M, Worth J. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cogn Behav Pract. 1999;6(4):332–41.CrossRef
30.
Safren SA, O’Cleirigh C, Tan JY, et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals. Health Psychol. 2009;28(1):1–10.PubMedCrossRef
31.
Brigido LF, Rodrigues R, Casseb J, et al. Impact of adherence to antiretroviral therapy in HIV-1-infected patients at a university public service in Brazil. AIDS Patient Care STDS. 2001;15(11):587–93.PubMedCrossRef
32.
Mills EJ, Nachega JB, Bangsberg DR, et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 2006;3(11):e438.PubMedCrossRef
33.
Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34(3):281–8.PubMedCrossRef
34.
Zogg JB, Woods SP, Sauceda JA, Wiebe JS, Simoni JM. The role of prospective memory in medication adherence: a review of an emerging literature. J Behav Med. 2011;35(1):47–62.PubMedCrossRef
35.
Andrade ASA, McGruder HF, Wu AW, et al. A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairment. Clin Infect Dis. 2005;41(6):875–82.PubMedCrossRef
36.
Safren SA, Hendriksen ES, Desousa N, Boswell SL, Mayer KH. Use of an on-line pager system to increase adherence to antiretroviral medications. AIDS Care. 2003;15(6):787–93.PubMedCrossRef
37.
Simoni JM, Huh D, Frick PA, et al. Peer support and pager messaging to promote antiretroviral modifying therapy in Seattle: a randomized controlled trial. J Acquir Immune Defic Syndr. 2009;52(4):465–73.PubMedCrossRef
38.
McKleroy VS, Galbraith JS, Cummings B, et al. Adapting evidence-based behavioral interventions for new settings and target populations. AIDS Educ Prev. 2006;18(4 Suppl A):59–73.PubMedCrossRef
39.
Nezu AM, Nezu CM, Felgoise SH, McClure KS, Houts PS. Project Genesis: assessing the efficacy of problem-solving therapy for distressed adult cancer patients. J Consult Clin Psychol. 2003;71(6):1036–48.PubMedCrossRef
40.
Organista K. Cognitive-behavioral therapy with Latinos and Latinas. In: Hays PA, Iwamasa GY, editors. Culturally responsive cognitive-behavior therapy: assessment, practice, and supervision. Washington: American Psychological Association; 2006. p. 73–96.CrossRef
41.
Bedoya CA, Safren SA. Capturing (and communicating) complexity: adapting CBT for clients with multiple diversity [commentary on the case of Felix: an example of gay-affirmative cognitive-behavioral therapy]. Pragmat Case Stud Psychother. 2009;5(2):22–7.
42.
Trinh NT, Bedoya CA, Chang TE, Flaherty K, Fava M, Yeung A. A study of a culturally focused psychiatric consultation service for Asian American and Latino American primary care patients with depression. BMC Psychiatry. 2011;11(1):166.PubMedCrossRef
43.
Brislin RW. Translation and content analysis of oral and written material. In: Triandis HC, Berry JW, editors. Handbook of cross-cultural psychology. Boston: Allyn & Bacon; 1980. p. 389–444.
44.
Amico KR, Fisher WA, Cornman DH, et al. Visual analog scale of ART adherence: association with 3-day self-report and adherence barriers. J Acquir Immune Defic Syndr. 2006;42(4):455–9.PubMedCrossRef
45.
Beck AT, Steer RA. Manual for the Beck Depression Inventory. San Antonio: Psychological Corporation; 1993.
46.
Bonicatto S, Dew AM, Soria JJ. Analysis of the psychometric properties of the Spanish version of the Beck Depression Inventory in Argentina. Psychiatry Res. 1998;79(3):277–85.PubMedCrossRef
47.
Sanz J, Vázquez C. Fiabilidad, validez, y datos normativos del inventario para la depresión de Beck [Reliability, validity, and normative data from the Beck Depression Inventory]. Psicothema. 1998;10:303–18.
48.
Suárez-Mendoza AA, Cardiel MH, Caballero-Uribe CV, Ortega-Soto HA, Márquez-Marín M. Measurement of depression in Mexican patients with rheumatoid arthritis: validity of the Beck Depression Inventory. Arthritis Care Res. 1997;10(3):194–9.PubMedCrossRef
49.
Kalichman SC, Rompa D, Cage M. Distinguishing between overlapping somatic symptoms of depression and HIV disease in people living with HIV-AIDS. J Nerv Ment Dis. 2000;188(10):662–70.PubMedCrossRef
50.
Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–9.PubMedCrossRef
51.
Lobo A, Chamorro L, Luque A, et al. Validation of the Spanish versions of the Montgomery–Asberg depression and Hamilton anxiety rating scales. Med Clin (Barc). 2002;118(13):493–9.PubMedCrossRef
52.
Kørner A, Nielsen BM, Eschen F, et al. Quantifying depressive symptomatology: inter-rater reliability and inter-item correlations. J Affect Disord. 1990;20(2):143–9.PubMedCrossRef
53.
Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73(1):13–22.CrossRef
54.
Huh D, Flaherty BP, Simoni JM. Optimizing the analysis of adherence interventions using logistic generalized estimating equations. AIDS Behav. 2011;16(2):422–31.CrossRef
55.
Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr. 2006;41(3):285–97.PubMedCrossRef
56.
Sikkema KJ, Watt MH, Drabkin AS, Meade CS, Hansen NB, Pence BW. Mental health treatment to reduce HIV transmission risk behavior: a positive prevention model. AIDS Behav. 2010;14(2):252–62.PubMedCrossRef
57.
58.
Kazdin AE, Blase SL. Rebooting psychotherapy research and practice to reduce the burden of mental illness. Perspect Psychol Sci. 2011;6(1):21–37.CrossRef
59.
60.
Robbins RN, D’Aquila E, Morgello S, Byrd D, Remien RH, Mindt MR. Cultural influences on antiretroviral therapy adherence among HIV-infected Puerto Ricans. J Assoc Nurses AIDS Care. 2012;23(6):531–8.PubMedCrossRef
61.
De Las Nueces D, Hacker K, DiGirolamo A, Hicks LS. A systematic review of community-based participatory research to enhance clinical trials in racial and ethnic minority groups. Health Serv Res. 2012;47(2):1363–86.CrossRef
62.
Becker MA, Martinez-Tyson D, DiGennaro J, Ochshorn E. Do Latino and non-Latino White Medicaid-enrolled adults differ in utilization of evidence-based treatment for major depressive disorder? J Immigr Minor Health. 2011;13(6):1048–54.PubMedCrossRef
63.
Keyes KM, Martins SS, Hatzenbuehler ML, Blanco C, Bates LM, Hasin DS. Mental health service utilization for psychiatric disorders among Latinos living in the United States: the role of ethnic subgroup, ethnic identity, and language/social preferences. Soc Psychiatry Psychiatr Epidemiol. 2012;47(3):383–94.PubMedCrossRef
64.
Soller M, Kharrazi N, Prentiss D, et al. Utilization of psychiatric services among low-income HIV-infected patients with psychiatric comorbidity. AIDS Care. 2011;23(11):1351–9.PubMedCrossRef
65.
Brown SD, Lee K, Schoffman DE, King AC, Crawley LM, Kiernand M. Minority recruitment into clinical trials: experimental findings and practical implications. Contemp Clin Trials. 2012;33(4):620–3.PubMedCrossRef
66.
Rivera-Goba MV, Dominguez DC, Stoll P, Grady C, Ramos C, Mican JM. Exploring decision-making of HIV-infected Hispanics and African Americans participating in clinical trials. J Assoc Nurses AIDS Care. 2011;22(4):295–306.PubMedCrossRef
67.
Gonzalez JS, Hendriksen ES, Collins EM, Durán RE, Safren SA. Latinos and HIV/AIDS: examining factors related to disparity and identifying opportunities for psychosocial intervention research. AIDS Behav. 2008;13(3):582–602.PubMedCrossRef
Metadata
Title
A Preliminary RCT of CBT-AD for Adherence and Depression Among HIV-Positive Latinos on the U.S.-Mexico Border: The Nuevo Día Study
Authors
Jane M. Simoni
John S. Wiebe
John A. Sauceda
David Huh
Giselle Sanchez
Virginia Longoria
C. Andres Bedoya
Steven A. Safren
Publication date
01-10-2013
Publisher
Springer US
Published in
AIDS and Behavior / Issue 8/2013
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-013-0538-5

Other articles of this Issue 8/2013

AIDS and Behavior 8/2013 Go to the issue

Original Paper

Adherence to HIV Treatment and Care Among Previously Homeless Jail Detainees

Original Paper

The Influence of Stigma and Discrimination on Female Sex Workers’ Access to HIV Services in St. Petersburg, Russia

Original Paper

Condom Distribution in Jail to Prevent HIV Infection

Original Paper

Law Enforcement Practices Associated with HIV Infection Among Injection Drug Users in Odessa, Ukraine

Original Paper

Routine Depression Screening in an HIV Clinic Cohort Identifies Patients with Complex Psychiatric Co-morbidities Who Show Significant Response to Treatment

Original Paper

Incarceration and Sexual Risk: Examining the Relationship Between Men’s Involvement in the Criminal Justice System and Risky Sexual Behavior
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits