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AIDS and Behavior
Published in: AIDS and Behavior 6/2011

Open Access 01-08-2011 | Original Paper

Neurocognitive Consequences of HIV Infection in Older Adults: An Evaluation of the “Cortical” Hypothesis

Authors: J. Cobb Scott, Steven Paul Woods, Catherine L. Carey, Erica Weber, Mark W. Bondi, Igor Grant, The HIV Neurobehavioral Research Center (HNRC) Group

Published in: AIDS and Behavior | Issue 6/2011

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Abstract

The incidence and prevalence of older adults living with HIV infection is increasing. Recent reports of increased neuropathologic and metabolic alterations in older HIV+ samples, including increased cortical beta-amyloid, have led some researchers to suggest that aging with HIV may produce a neuropsychological profile akin to that which is observed in “cortical” dementias (e.g., impairment in memory consolidation). To evaluate this possibility, we examined four groups classified by HIV serostatus and age (i.e., younger ≤40 years and older ≥50 years): (1) Younger HIV− (n = 24); (2) Younger HIV+ (n = 24); (3) Older HIV− (n = 20); and (4) Older HIV+ (n = 48). Main effects of aging were observed on episodic learning and memory, executive functions, and visuoconstruction, and main effects of HIV were observed on measures of verbal learning and memory. The interaction of age and HIV was observed on a measure of verbal recognition memory, which post hoc analyses showed to be exclusively attributed to the superior performance of the younger HIV seronegative group. Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a “cortical” pattern of cognitive deficits.
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Metadata
Title
Neurocognitive Consequences of HIV Infection in Older Adults: An Evaluation of the “Cortical” Hypothesis
Authors
J. Cobb Scott
Steven Paul Woods
Catherine L. Carey
Erica Weber
Mark W. Bondi
Igor Grant
The HIV Neurobehavioral Research Center (HNRC) Group
Publication date
01-08-2011
Publisher
Springer US
Published in
AIDS and Behavior / Issue 6/2011
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-010-9815-8

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