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AIDS and Behavior
Published in: AIDS and Behavior 6/2010

01-12-2010 | Original Paper

Physiological and Psychosocial Factors that Predict HIV-Related Fatigue

Authors: Julie Barroso, Bradley G. Hammill, Jane Leserman, Naima Salahuddin, James L. Harmon, Brian Wells Pence

Published in: AIDS and Behavior | Issue 6/2010

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Abstract

Fatigue is one of the most common and debilitating symptoms experienced by HIV-infected people. We report the results of our longitudinal analysis of physiological and psychosocial factors that were thought to predict changes in HIV-related fatigue in 128 participants over a 1-year period, in an effort to sort out the complex interplay among a comprehensive set of physiological and psychosocial variables. Physiological measures included hepatic function (aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase, total bilirubin, hepatitis C status), thyroid function (thyroid stimulating hormone, thyroxine), HIV viral load, immunologic function (CD4, CD8, CD4/CD8 ratio, CD16, CD8CD38), gonadal function (testosterone, dehydroepiandrosterone), hematologic function (hemoglobin, hematocrit, serum erythropoietin), and cellular injury (lactic acid). Psychosocial measures included childhood and adult trauma, anxiety, depression, social support, stressful life events, and post-traumatic stress disorder (PTSD). Unemployment, not being on antiretroviral therapy, having fewer years since HIV diagnosis, more childhood trauma, more stressful life events, less social support, and more psychological distress (e.g., PTSD, anxiety and depression) put HIV-infected persons at risk for greater fatigue intensity and fatigue-related impairment in functioning during 1-year follow-up. Physiological variables did not predict greater fatigue. Stressful life events had both direct and indirect effects on fatigue.
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Metadata
Title
Physiological and Psychosocial Factors that Predict HIV-Related Fatigue
Authors
Julie Barroso
Bradley G. Hammill
Jane Leserman
Naima Salahuddin
James L. Harmon
Brian Wells Pence
Publication date
01-12-2010
Publisher
Springer US
Published in
AIDS and Behavior / Issue 6/2010
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-010-9691-2

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