Top

Published in:

01-04-2009 | Original Paper

Associations Between Substance Use, Erectile Dysfunction Medication and Recent HIV Infection Among Men Who have Sex with Men

Authors: Lydia N. Drumright, Pamina M. Gorbach, Susan J. Little, Steffanie A. Strathdee

Published in: AIDS and Behavior | Issue 2/2009

Abstract

We conducted a case-control study to compare illicit substance and erectile dysfunction medication (EDM) use between recently HIV-infected and uninfected men who have sex with men (MSM). Eighty-six recently (previous 12 months) HIV-infected MSM (cases) and 59 MSM who recently tested HIV-negative (controls) completed computer-assisted self-interviews. There were no statistical differences in demographics or number of sexual partners by HIV status. Cases were more likely than controls to report methamphetamine or nitrite use, but not EDM, gamma hydroxybutyrate, 3,4 methylenedioxymethamphetamine, cocaine, or marijuana use, in the previous 12 months and with their last three sexual partners in multivariate logistic regression models. Use of nitrites and amphetamine may increase HIV risk among MSM.

Brewer, D. D., Golden, M. R., & Handsfield, H. H. (2006). Unsafe sexual behavior and correlates of risk in a probability sample of men who have sex with men in the era of highly active antiretroviral therapy. Sexually Transmitted Diseases, 33, 250–255.PubMedCrossRef

Buchbinder, S., Vittinghoff, E., Heagerty, P., Celum, C., Seage, G., Judson, F. N., et al. (2005). Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States. Journal of Acquired Immune Deficiency Syndromes, 39, 82–89.PubMedCrossRef

Burcham, J. L., Tindall, B., Marmor, M., Cooper, D. A., Berry, G., & Penny, R. (1989). Incidence and risk factors for human immunodeficiency virus seroconversion in a cohort of Sydney homosexual men. The Medical Journal of Australia, 150, 634–639.PubMed

Celentano, D. D., Valleroy, L. A., Sifakis, F., MacKellar, D. A., Hylton, J., Thiede, H., et al. (2006). Associations between substance use and sexual risk among very young men who have sex with men. Sexually Transmitted Diseases, 33, 265–271.PubMed

Chesney, M. A., Barrett, D. C., & Stall, R. (2005). Histories of substance use and risk behavior: Precursors to HIV seroconversion in homosexual men. American Journal of Public Health, 88, 113–116.CrossRef

Chmiel, J. S., Detels, R., Kaslow, R. A., van Raden, M., Kingsley, L. A., & Brookmeyer, R. (1987). Factors associated with prevalent human immunodeficiency virus (HIV) infection in the multicenter AIDS cohort study. American Journal of Epidemiology, 126, 568–575.PubMed

Choi, K. H., Operario, D., Gregorich, S. E., McFarland, W., MacKellar, D., & Valleroy, L. (2005). Substance use, substance choice, and unprotected anal intercourse among young Asian American and Pacific Islander men who have sex with men. Aids Education and Prevention, 17, 418–429.PubMedCrossRef

Chu, P. L., McFarland, W., Gibson, S., Weide, D., Henne, J., Miller, P., et al. (2003). Viagra use in a community-recruited sample of men who have sex with men, San Francisco. Journal of Acquired Immune Deficiency Syndromes, 33, 191–193.PubMedCrossRef

Clutterbuck, D. J., Gorman, D., McMillan, A., Lewis, R., & Macintyre, C. C. (2001). Substance use and unsafe sex amongst homosexual men in Edinburgh. AIDS Care, 13, 527–535.PubMedCrossRef

Colfax, G., Coates, T. J., Husnik, M. J., Huang, Y., Buchbinder, S., Koblin, B., et al. (2005). Longitudinal patterns of methamphetamine, popper (amyl nitrite), and cocaine use and high-risk sexual behavior among a cohort of San Francisco men who have sex with men. Journal of Urban Health, 82, i62–i70.PubMed

Colfax, G. N., Mansergh, G., Guzman, R., Vittinghoff, E., Marks, G., Rader, M., et al. (2001). Drug use and sexual risk behavior among gay and bisexual men who attend circuit parties: A venue-based comparison. Journal of Acquired Immune Deficiency Syndromes, 28, 373–379.PubMed

Crosby, R., & DiClemente, R. J. (2004). Use of recreational Viagra among men having sex with men. Sexually Transmitted Infections, 80, 466–468.PubMedCrossRef

Daar, E. S., Little, S., Pitt, J., Santangelo, J., Ho, P., Harawa, N., et al. (2001). Diagnosis of primary HIV-1 infection. Annals of Internal Medicine, 134, 25–29.PubMed

Drumright, L. N., Little, S. J., Strathdee, S. A., Slymen, D. J., Araneta, M. R. G., Malcarne, et al. (2006). Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infection. Journal of Acquired Immune Deficiency Syndromes, 43, 344–350.

Ekstrand, M. L., Stall, R. D., Paul, J. P., Osmond, D. H., & Coates, T. J. (1999). Gay men report high rates of unprotected anal sex with partners of unknown or discordant HIV status. AIDS, 13, 1525–1533.PubMedCrossRef

Ghanem, K. G., Hutton, H. E., Zenilman, J. M., Zimba, R., & Erbelding, E. J. (2005). Audio computer assisted self interview and face to face interview modes in assessing response bias among STD clinic patients. Sexually Transmitted Infections, 81, 421–425.PubMedCrossRef

Gillmore, M. R., Morrision, D. M., Leigh, B. C., Hoppe, M. J., Gaylord, J., & Rainey, D. T. (2002). Does “high = high risk”? An event-based analysis of the relationship between substance use and unprotected anal sex among gay and bisexual men. AIDS and Behavior, 6, 361–370.CrossRef

Harawa, N. T., Greenland, S., Bingham, T. A., Johnson, D. F., Cochran, S. D., Cunningham, W. E., et al. (2004). Associations of race/ethnicity with HIV prevalence and HIV-related behaviors among young men who have sex with men in 7 urban centers in the United States. Journal of Acquired Immune Deficiency Syndromes, 35, 526–536.PubMedCrossRef

Hayaki, J., Anderson, B., & Stein, M. (2006). Sexual risk behaviors among substance users: Relationship to impulsivity. Psychology of Addictive Behaviors, 20, 328–332.PubMedCrossRef

Hewitt, M. (2002). Attitudes toward interview mode and comparability of reporting sexual behavior by personal interview and audio computer-assisted self-interviewing—Analyses of the 1995 National Survey of Family Growth. Sociological Methods & Research, 31, 3–26.CrossRef

Hirshfield, S., Remien, R. H., Humberstone, M., Walavalkar, I., & Chiasson, M. A. (2004a). Substance use and high-risk sex among men who have sex with men: A national online study in the USA. AIDS Care, 16, 1036–1047.PubMedCrossRef

Hirshfield, S., Remien, R. H., Walavalkar, I., & Chiasson, M. A. (2004b). Crystal methamphetamine use predicts incident STD infection among men who have sex with men recruited online: A nested case-control study. Journal of Medical Internet Research, 6, 42–49.CrossRef

Kalichman, S. C., Heckman, T., & Kelly, J. A. (1996). Sensation seeking as an explanation for the association between substance use and HIV-related risky sexual behavior. Archives of Sexual Behavior, 25, 141–154.PubMedCrossRef

Kim, A. A., Kent, C. K., & Klausner, J. D. (2002). Increased risk of HIV and sexually transmitted disease transmission among gay or bisexual men who use Viagra, San Francisco 2000–2001. AIDS, 16, 1425–1428.PubMedCrossRef

Klitzman, R. L., Greenberg, J. D., Pollack, L. M., & Dolezal, C. (2002). MDMA (‘ecstasy’) use, and its association with high risk behaviors, mental health, and other factors among gay/bisexual men in New York City. Drug and Alcohol Dependence, 66, 115–125.PubMedCrossRef

Klitzman, R. L., Pope, H. G., & Hudson, J. I. (2000). MDMA (“ecstasy”) abuse and high-risk sexual behaviors among 169 gay and bisexual men. The American Journal of Psychiatry, 157, 1162–1164.PubMedCrossRef

Koblin, B. A., Husnik, M. J., Colfax, G., Huang, Y. J., Madison, M., Mayer, K., et al. (2006). Risk factors for HIV infection among men who have sex with men. AIDS, 20, 731–739.PubMedCrossRef

Kurth, A. E., Martin, D. P., Golden, M. R., Weiss, N. S., Heagerty, P. J., Spielberg, F., et al. (2004). A comparison between audio computer-assisted self-interviews and clinician interviews for obtaining the sexual history. Sexually Transmitted Diseases, 31, 719–726.PubMedCrossRef

Lee, S. J., Galanter, M., Dermatis, H., & McDowell, D. (2003). Circuit parties and patterns of drug use in a subset of gay men. Journal of Addictive Diseases, 22, 47–60.PubMedCrossRef

Little, S. J., Daar, E. S., D’Aquila, R. T., Keiser, P. H., Connick, E., Whitcomb, J. M., et al. (1999). Reduced antiretroviral drug susceptibility among patients with primary HIV infection. Journal of the American Medical Association, 282, 1142–1149.PubMedCrossRef

Mansergh, G., Shouse, R. L., Marks, G., Guzman, R., Rader, M., Buchbinder, S., et al. (2006). Methamphetamine and sildenafil (Viagra) use are linked to unprotected receptive and insertive anal sex, respectively, in a sample of men who have sex with men. Sexually Transmitted Infections, 82, 131–134.PubMedCrossRef

Mccoul, M. D., & Haslam, N. (2001). Predicting high risk sexual behaviour in heterosexual and homosexual men: The roles of impulsivity and sensation seeking. Personality and Individual Differences, 31, 1303–1310.CrossRef

Molitor, F., Truax, S. R., Ruiz, J. D., & Sun, R. K. (1998). Associations with methamphetamine use during sex with risky sexual behaviors and HIV infection among non-injection drug users. Western Journal of Medicine, 168, 93–97.PubMed

Morin, S. F., Steward, W. T., Charlebois, E. D., Remien, R. H., Pinkerton, S. D., Johnson, M. O., et al. (2005). Predicting HIV transmission risk among HIV-infected men who have sex with men—Findings from the Healthy Living Project. Journal of Acquired Immune Deficiency Syndromes, 40, 226–235.PubMedCrossRef

Mulry, G., Kalichman, S. C., & Kelly, J. A. (1994). Substance use and unsafe sex among gay men—Global versus situational use of substances. Journal of Sex Education and Therapy, 20, 175–184.

Murphy, D. A., Durako, S., Muenz, L. R., & Wilson, C. M. (2000). Marijuana use among HIV-positive and high-risk adolescents: A comparison of self-report through audio computer-assisted self-administered interviewing and urinalysis. American Journal of Epidemiology, 152, 805–813.PubMedCrossRef

Ostrow, D. G., Beltran, E. D., Joseph, J. G., Difranceisco, W., Wesch, J., & Chmiel, J. S. (1993). Recreational drugs and sexual behavior in the Chicago MACS/CCS cohort of homosexually active men. Chicago Multicenter AIDS Cohort Study (MACS)/Coping and Change Study. Journal of Substance Abuse, 5, 311–325.PubMedCrossRef

Ostrow, D. G., DiFranceisco, W. J., Chmiel, J. S., Wagstaff, D. A., & Wesch, J. (1995). A case-control study of human immunodeficiency virus type 1 seroconversion and risk-related behaviors in the Chicago MACS/CCS Cohort, 1984–1992. Multicenter AIDS Cohort Study. Coping and Change Study. American Journal of Epidemiology, 142, 875–883.PubMed

PageShafer, K., Veugelers, P. J., Moss, A. R., Strathdee, S., Kaldor, J. M., & vanGriensven, G. J. P. (1997). Sexual risk behavior and risk factors for HIV-1 seroconversion in homosexual men participating in the tricontinental seroconverter study, 1982–1994. American Journal of Epidemiology, 146, 531–542.

Paschall, M. J., Ornstein, M. L., & Flewelling, R. L. (2001). African American male adolescents’ involvement in the criminal justice system: The criterion validity of self-report measures in a prospective study. Journal of Research in Crime and Delinquency, 38, 174–187.CrossRef

Patterson, T. L., Semple, S. J., Zians, J. K., & Strathdee, S. A. (2005). Methamphetamine-using HIV-positive men who have sex with men: Correlates of polydrug use. Journal of Urban Health, 82, I120–I126.PubMed

Paul, J. P., Pollack, L., Osmond, D., & Catania, J. A. (2005). Viagra (sildenafil) use in a population-based sample of U.S. men who have sex with men. Sexually Transmitted Diseases, 32, 531–533.PubMedCrossRef

Perlis, T. E., Des Jarlais, D. C., Friedman, S. R., Arasteh, K., & Turner, C. F. (2004). Audio-computerized self-interviewing versus face-to-face interviewing for research data collection at drug abuse treatment programs. Addiction, 99, 885–896.PubMedCrossRef

Plankey, M. W., Ostrow, D. G., Stall, R., Cox, C., Li, X., Peck, J.A., et al. (2007). The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study. Journal of Acquired Immune Deficiency Syndromes, 45, 85–92.PubMedCrossRef

Purcell, D. W., Wolitski, R. J., Hoff, C. C., Parsons, J. T., Woods W. J., & Halkitis, P. N. (2005). Predicotrs of the use of Viagra, testosterone, and antidepressants among HIV-seropositive gay and bisexual men. AIDS, 19, S57–S66.PubMedCrossRef

Rogers, S. M., Willis, G., Al Tayyib, A., Villarroel, M. A., Turner, C. F., Ganapathi, L., et al. (2005). Audio computer assisted interviewing to measure HIV risk behaviours in a clinic population. Sexually Transmitted Infections, 81, 501–507.PubMedCrossRef

Rusch, M., Lampinen, T. M., Schilder, A., & Hogg, R. S. (2004). Unprotected anal intercourse associated with recreational drug use among young men who have sex with men depends on partner type and intercourse role. Sexually Transmitted Diseases, 31, 492–498.PubMedCrossRef

Sanchez, T. H., & Gallagher, K. M. (2006). Factors associated with recent sildenafil (Viagra) use among men who have sex with men in the United States. Journal of Acquired Immune Deficiency Syndromes, 42, 95–100.PubMedCrossRef

Schlesselman, J. J. (1982). Case-control studies: Design, conduct, analysis. New York: Oxford University Press.

Simoes, A. A., Bastos, F. I., Moreira, R. I., Lynch, K. G., & Metzger, D. S. (2006). A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil. Journal of Substance Abuse Treatment, 30, 237–243.PubMedCrossRef

Strathdee, S. A., Hogg, R. S., Martindale, S. L., Cornelisse, P. G., Craib, K. J., Montaner, J. S., et al. (1998). Determinants of sexual risk-taking among young HIV-negative gay and bisexual men. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 19, 61–66.PubMed

van Griensven, F., Naorat, S., Kilmarx, P. H., Jeeyapant, S., Manopaiboon, C., Chaikummao, S., et al. (2006). Palmtop-assisted self-interviewing for the collection of sensitive behavioral data: Randomized trial with drug use urine testing. American Journal of Epidemiology, 163, 271–278.PubMedCrossRef

Waldo, C. R., McFarland, W., Katz, M. H., MacKellar, D., & Valleroy, L. A. (2000). Very young gay and bisexual men are at risk for HIV infection: The San Francisco Bay Area Young Men's Survey II. Journal of Acquired Immune Deficiency Syndromes, 24, 168–174.PubMed

Wong, W., Chaw, J. K., Kent, C. K., & Klausner, J. D. (2005). Risk factors for early syphilis among gay and bisexual men seen in an STD clinic: San Francisco, 2002–2003. Sexually Transmitted Diseases, 32, 458–463.PubMedCrossRef

Woody, G. E., Donnell, D., Seage, G. R., Metzger, D., Marmor, M., Koblin, B. A., et al. (1999). Non-injection substance use correlates with risky sex among men having sex with men: Data from HIVNET. Drug and Alcohol Dependence, 53, 197–205.PubMedCrossRef

Title: Associations Between Substance Use, Erectile Dysfunction Medication and Recent HIV Infection Among Men Who have Sex with Men
Authors: Lydia N. Drumright
Pamina M. Gorbach
Susan J. Little
Steffanie A. Strathdee
Publication date: 01-04-2009
Publisher: Springer US
Published in: AIDS and Behavior / Issue 2/2009
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-007-9330-8

ACC 2024 Congress Coverage

Cardiology Video

Highlights from the ACC 2024 Congress

Watch now

Watch official videos from the ACC congress summarizing key highlights from the last year in heart failure, cardiomyopathies, valvular disease, pulmonary vascular disease, and pediatric cardiology.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

ACC 2024 Congress

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2009

Factors Associated with Low Early Uptake of a National Program to Prevent Mother to Child Transmission of HIV (PMTCT): Results of a Survey of Mothers and Providers, Botswana, 2003

Implementation Challenges to Using Respondent-Driven Sampling Methodology for HIV Biological and Behavioral Surveillance: Field Experiences in International Settings

Sexual Behavior and Risk Factors for HIV Infection Among Homosexual and Bisexual Men in Thailand

The Influence of Personality Disorder Indication, Social Support, and Grief on Alcohol and Cocaine Use among HIV-Positive Adults Coping with AIDS-Related Bereavement