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Angiogenesis
Published in: Angiogenesis 4/2022

Open Access 20-07-2022 | Obesity | Review Paper

Angiogenesis in adipose tissue and obesity

Authors: Silvia Corvera, Javier Solivan-Rivera, Zinger Yang Loureiro

Published in: Angiogenesis | Issue 4/2022

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Abstract

While most tissues exhibit their greatest growth during development, adipose tissue is capable of additional massive expansion in adults. Adipose tissue expandability is advantageous when temporarily storing fuel for use during fasting, but becomes pathological upon continuous food intake, leading to obesity and its many comorbidities. The dense vasculature of adipose tissue provides necessary oxygen and nutrients, and supports delivery of fuel to and from adipocytes under fed or fasting conditions. Moreover, the vasculature of adipose tissue comprises a major niche for multipotent progenitor cells, which give rise to new adipocytes and are necessary for tissue repair. Given the multiple, pivotal roles of the adipose tissue vasculature, impairments in angiogenic capacity may underlie obesity-associated diseases such as diabetes and cardiometabolic disease. Exciting new studies on the single-cell and single-nuclei composition of adipose tissues in mouse and humans are providing new insights into mechanisms of adipose tissue angiogenesis. Moreover, new modes of intercellular communication involving micro vesicle and exosome transfer of proteins, nucleic acids and organelles are also being recognized to play key roles. This review focuses on new insights on the cellular and signaling mechanisms underlying adipose tissue angiogenesis, and on their impact on obesity and its pathophysiological consequences.
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Metadata
Title
Angiogenesis in adipose tissue and obesity
Authors
Silvia Corvera
Javier Solivan-Rivera
Zinger Yang Loureiro
Publication date
20-07-2022
Publisher
Springer Netherlands
Keywords
Obesity
Obesity
Published in
Angiogenesis / Issue 4/2022
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-022-09848-3

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