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Angiogenesis
Published in: Angiogenesis 2/2020

01-05-2020 | Perspective

Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis

Author: Coert Margadant

Published in: Angiogenesis | Issue 2/2020

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Abstract

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.
Literature
1.
Simons M, Gordon E, Claesson-Welsh L (2016) Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol 17(10):611–625CrossRef
2.
del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A (2010) Identification and functional analysis of endothelial tip cell-enriched genes. Blood 116(19):4025–4033CrossRef
3.
Dallinga MG, Yetkin-Arik B, Kayser RP, Vogels IMC, Nowak-Sliwinska P, Griffioen AW, van Noorden CJF, Klaassen I, Schlingemann RO (2018) IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers. Angiogenesis 21(4):823–836CrossRef
4.
Jakobsson L, Bentley K, Gerhardt H (2009) VEGFRs and Notch: a dynamic collaboration in vascular patterning. Biochem Soc Trans. 37(Pt 6):1233–1236CrossRef
5.
Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL, Chico TJA, Wilkinson RN (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nat Commun 10(1):732CrossRef
6.
Page DJ, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert SP (2019) Positive feedback defines the timing, magnitude, and robustness of angiogenesis. Cell Rep 27(11):3139–3151CrossRef
7.
Kim YH, Choi J, Yang MJ, Hong SP, Lee CK, Kubota Y, Lim DS, Koh GY (2019) A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis. Nat Commun 10(1):838CrossRef
8.
Fukumoto M, Kondo K, Uni K, Ishiguro T, Hayashi M, Ueda S, Mori I, Niimi K, Tashiro F, Miyazaki S, Miyazaki JI, Inagaki S, Furuyama T (2018) Tip-cell behavior is regulated by transcription factor FoxO1 under hypoxic conditions in developing mouse retinas. Angiogenesis 21(2):203–214CrossRef
9.
Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M (2018) aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun 9(1):5357CrossRef
10.
Pontes-Quero S, Fernández-Chacón M, Luo W, Lunella FF, Casquero-Garcia V, Garcia-Gonzalez I, Hermoso A, Rocha SF, Bansal M, Benedito R (2019) High mitogenic stimulation arrests angiogenesis. Nat Commun 10(1):2016CrossRef
Metadata
Title
Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis
Author
Coert Margadant
Publication date
01-05-2020
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 2/2020
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-020-09706-0

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