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Angiogenesis
Published in: Angiogenesis 3/2017

Open Access 01-08-2017 | Review Paper

The role of vasculature in bone development, regeneration and proper systemic functioning

Authors: Joanna Filipowska, Krzysztof A. Tomaszewski, Łukasz Niedźwiedzki, Jerzy A. Walocha, Tadeusz Niedźwiedzki

Published in: Angiogenesis | Issue 3/2017

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Abstract

Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients, hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is indispensable for appropriate bone development, regeneration and remodeling. Bone vasculature also orchestrates the process of hematopoiesis. Blood supply to the skeletal system is provided by the networks of arteries and arterioles, having distinct molecular characteristics and localizations within the bone structures. Blood vessels of the bone develop through the process of angiogenesis, taking place through different, bone-specific mechanisms. Impaired functioning of the bone blood vessels may be associated with the occurrence of some skeletal and systemic diseases, i.e., osteonecrosis, osteoporosis, atherosclerosis or diabetes mellitus. When a disease or trauma-related large bone defects appear, bone grafting or bone tissue engineering-based strategies are required. However, a successful bone regeneration in both approaches largely depends on a proper blood supply. In this paper, we review the most recent data on the functions, molecular characteristics and significance of the bone blood vessels, with a particular emphasis on the role of angiogenesis and blood vessel functioning in bone development and regeneration, as well as the consequences of its impairment in the course of different skeletal and systemic diseases.
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Metadata
Title
The role of vasculature in bone development, regeneration and proper systemic functioning
Authors
Joanna Filipowska
Krzysztof A. Tomaszewski
Łukasz Niedźwiedzki
Jerzy A. Walocha
Tadeusz Niedźwiedzki
Publication date
01-08-2017
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 3/2017
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-017-9541-1

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