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Published in: Angiogenesis 2/2013

01-04-2013 | Original Paper

The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action

Authors: Avner Adini, Irit Adini, Kaustabh Ghosh, Ofra Benny, Elke Pravda, Ron Hu, Dema Luyindula, Robert J. D’Amato

Published in: Angiogenesis | Issue 2/2013

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Abstract

Prominin-1, a pentaspan transmembrane protein, is a unique cell surface marker commonly used to identify stem cells, including endothelial progenitor cells and cancer stem cells. However, recent studies have shown that prominin-1 expression is not restricted to stem cells but also occurs in modified forms in many mature adult human cells. Although prominin-1 has been studied extensively as a stem cell marker, its physiological function of the protein has not been elucidated. We investigated prominin-1 function in two cell lines, primary human endothelial cells and B16-F10 melanoma cells, both of which express high levels of prominin-1. We found that prominin-1 directly interacts with the angiogenic and tumor survival factor vascular endothelial growth factor (VEGF) in both the primary endothelial cells and the melanoma cells. Knocking down prominin-1 in the endothelial cells disrupted capillary formation in vitro and decreased angiogenesis in vivo. Similarly, tumors derived from prominin-1 knockdown melanoma cells had a reduced growth rate in vivo. Further, melanoma cells with knocked down prominin-1 had diminished ability to interact with VEGF, which was associated with decreased bcl-2 protein levels and increased apoptosis. In vitro studies with soluble prominin-1 showed that it stabilized dimer formation of VEGF164, but not VEGF121. Taken together, our findings support the notion that prominin-1 plays an active role in cell growth through its ability to interact and potentiate the anti-apoptotic and pro-angiogenic activities of VEGF. Additionally, prominin-1 promotes tumor growth by supporting angiogenesis and inhibiting tumor cell apoptosis.
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Metadata
Title
The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action
Authors
Avner Adini
Irit Adini
Kaustabh Ghosh
Ofra Benny
Elke Pravda
Ron Hu
Dema Luyindula
Robert J. D’Amato
Publication date
01-04-2013
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 2/2013
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-012-9323-8

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