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Angiogenesis
Published in: Angiogenesis 2/2013

01-04-2013 | Review Paper

PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow

Authors: Hakan Orbay, Hao Hong, Yin Zhang, Weibo Cai

Published in: Angiogenesis | Issue 2/2013

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Abstract

Peripheral artery disease (PAD) is a result of the atherosclerotic narrowing of blood vessels to the extremities, and the subsequent tissue ischemia can lead to the up-regulation of angiogenic growth factors and formation of new vessels as a recovery mechanism. Such formation of new vessels can be evaluated with various non-invasive molecular imaging techniques, where serial images from the same subjects can be obtained to allow the documentation of disease progression and therapeutic response. The most commonly used animal model for preclinical studies of PAD is the murine hindlimb ischemia model, and a number of radiotracers have been investigated for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of PAD. In this review article, we summarize the PET/SPECT tracers that have been tested in the murine hindlimb ischemia model as well as those used clinically to assess the extremity blood flow.
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Metadata
Title
PET/SPECT imaging of hindlimb ischemia: focusing on angiogenesis and blood flow
Authors
Hakan Orbay
Hao Hong
Yin Zhang
Weibo Cai
Publication date
01-04-2013
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 2/2013
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-012-9319-4

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