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Angiogenesis
Published in: Angiogenesis 1/2008

01-03-2008 | Original Paper

Hedgehog signalling in vascular development

Authors: Takashi Nagase, Miki Nagase, Masafumi Machida, Toshiro Fujita

Published in: Angiogenesis | Issue 1/2008

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Abstract

The Hedgehog family of proteins are powerful morphogens mediating embryonic development as well as adult morphogenesis and carcinogenesis. For example, excess hedgehog activity has been implicated in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma. More recently, hedgehog signalling has been implicated in angiogenesis. While hedgehog signalling in adult angiogenesis may constitute a simple recapitulation of that in embryonic development, it should be appreciated that Hedgehog signalling occurs in embryonic angiogenesis in different developmental contexts. This article reviews the role of Hedgehog signalling in both embryonic and postnatal vascular development. The temporal importance of a window of hedgehog dependent angiogenesis during development is emphasised and illustrated using a whole mouse embryo culture system.
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Metadata
Title
Hedgehog signalling in vascular development
Authors
Takashi Nagase
Miki Nagase
Masafumi Machida
Toshiro Fujita
Publication date
01-03-2008
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 1/2008
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-008-9105-5

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