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Journal of Medical Ultrasonics

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01-07-2015 | Original Article

Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results

Authors: Seiji Mabuchi, Tomoyuki Sasano, Hiromasa Kuroda, Ryoko Takahashi, Satoshi Nakagawa, Tadashi Kimura

Published in: Journal of Medical Ultrasonics | Issue 3/2015

Abstract

Purpose

To investigate the utility of real-time sonoelastography (RTE) for predicting treatment response during the course of definitive radiotherapy in patients with cervical cancer.

Methods

Cervical cancer patients were prospectively evaluated with RTE by a single operator during the course of definitive radiotherapy to analyze the associations between the change in their tumor’s strain ratio (SR) and the treatment response.

Results

The SR of the cervical tumors was significantly higher than that of the normal cervical tissue (mean 3.8 vs 1.2; median 3.4 vs 1.1, p < 0.01). Treating the cervical tumors with definitive radiotherapy significantly reduced their SR to the same level as the normal cervix among patients who achieved a complete response to definitive radiotherapy. In contrast, among patients who developed residual disease after radiotherapy, the SR of the tumor did not decrease significantly after definitive radiotherapy. Moreover, the reduction in the tumor SR detected by RTE preceded the reduction in tumor volume as assessed by transvaginal ultrasonography.

Conclusion

RTE is a rapid and effective method for predicting treatment response during the course of definitive radiotherapy, potentially facilitating early and personalized treatment adaptation in patients with cervical cancer.

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Title: Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results
Authors: Seiji Mabuchi
Tomoyuki Sasano
Hiromasa Kuroda
Ryoko Takahashi
Satoshi Nakagawa
Tadashi Kimura
Publication date: 01-07-2015
Publisher: Springer Japan
Published in: Journal of Medical Ultrasonics / Issue 3/2015
Print ISSN: 1346-4523
Electronic ISSN: 1613-2254
DOI: https://doi.org/10.1007/s10396-015-0616-6

At a glance: The STEP trials

Springer Medicine

Real-time tissue sonoelastography for early response monitoring in cervical cancer patients treated with definitive chemoradiotherapy: preliminary results

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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