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Esophagus
Published in: Esophagus 4/2020

Open Access 01-10-2020 | Review Article

Submucosal gland neoplasms of the esophagus: an update and review

Authors: Ling Nie, Wei Li, Liyan Xue, Lin Wang, Yonghua Shen, Xiangshan Fan

Published in: Esophagus | Issue 4/2020

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Abstract

Submucosal glands (SMGs) present throughout human esophagus with clusters at either the upper third or lower third of the organ. SMGs tend to atrophy with age, and neoplasms arising in these glands are rare. In order to bring convenience to diagnosis, we summarize the histopathologic characteristics of all esophageal submucosal gland tumors (SGTs). Due to the morphological similarity, the nomenclature of salivary tumors is adopted for SGTs. However, there is great confusion about the definition and histogenesis of these tumors, especially the malignant subtypes. In the literature, esophageal mucoepidermoid carcinoma and adenoid cystic carcinoma usually adjoin the surface squamous epithelium and coexist with intraepithelial neoplasia or invasive squamous cell carcinoma (SCC). In addition, the typical gene alterations of salivary tumors have not been reported in these SGTs. Therefore, we propose to apply stringent diagnostic criteria to esophageal SGTs so as to exclude mimickers that are SCCs with various degree of SMG differentiation.
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Metadata
Title
Submucosal gland neoplasms of the esophagus: an update and review
Authors
Ling Nie
Wei Li
Liyan Xue
Lin Wang
Yonghua Shen
Xiangshan Fan
Publication date
01-10-2020
Publisher
Springer Singapore
Published in
Esophagus / Issue 4/2020
Print ISSN: 1612-9059
Electronic ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-020-00758-1

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