Skip to main content
Top
Published in: Japanese Journal of Ophthalmology 3/2018

01-05-2018 | Clinical Investigation

The effect of orthokeratology on axial length elongation in children with myopia: Contralateral comparison study

Authors: Miri Na, Aeri Yoo

Published in: Japanese Journal of Ophthalmology | Issue 3/2018

Login to get access

Abstract

Purpose

To evaluate the effectiveness of the orthokeratology (OK) lens slowing myopic progression compared with no intervention in pediatric eyes

Methods

A retrospective review of medical records was performed on 45 monocular myopic subjects 7 to 13 years of age who were treated with monocular ortho-k lens and followed-up for more than 12 months. The monocular myopia in the subjects’ eyes was -0.75 to -4.25 D (diopter), and near emmetropia in the contralateral and with-the-rule astigmatism no greater than -1.50 D. Axial elongation OU, reflecting the progression of myopia was measured at baseline using the same AL-Scan Optical Biometer and compared between the two eyes of each individual every six months for one year in all subjects and for two years in 9 subjects.

Results

After 12 months of lens wear, axial length had increased by 0.36 ± 0.23mm in the control eyes (P < 0.001) but showed far less change (+0.07 ± 0.21 mm) in the OK eyes (P = 0.038). The nine subjects followed-up for 2 years showed no axial length change (+0.16 ± 0.25 mm) in the OK eyes (P = 0.095) after 24 months and significant axial length growth (+0.38 ± 0.26 mm; P = 0.002) in the control eyes. Control eyes showed progressive axial length growth throughout the study compared with the one OK lens eye.

Conclusions

Using a contralateral eye study design, which prevented the influence of potential confounding factors, Effectiveness of the OK lens was proved. Myopic progression within a subject was excellent compared with no intervention
Literature
1.
go back to reference Kempen JH, Mitchell P, Lee KE, Tielsch JM, Broman AT, Taylor HR, et al. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Arch Ophthalmol. 2004;122:495–505.CrossRefPubMed Kempen JH, Mitchell P, Lee KE, Tielsch JM, Broman AT, Taylor HR, et al. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Arch Ophthalmol. 2004;122:495–505.CrossRefPubMed
2.
go back to reference He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, et al. Effect of time spent outdoors at school on the development of myopia among children in china: a randomized clinical trial. JAMA. 2015;314:1142–8.CrossRefPubMed He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, et al. Effect of time spent outdoors at school on the development of myopia among children in china: a randomized clinical trial. JAMA. 2015;314:1142–8.CrossRefPubMed
4.
go back to reference Li SM, Ji YZ, Wu SS, Zhan SY, Wang B, Liu LR, et al. Multifocal versus single vision lenses intervention to slow progression of myopia in school-age children: a meta-analysis. Surv Ophthalmol. 2011;56:451–60.CrossRefPubMed Li SM, Ji YZ, Wu SS, Zhan SY, Wang B, Liu LR, et al. Multifocal versus single vision lenses intervention to slow progression of myopia in school-age children: a meta-analysis. Surv Ophthalmol. 2011;56:451–60.CrossRefPubMed
5.
go back to reference Li SM, Kang MT, Wu SS, Meng B, Sun YY, Wei SF, et al. Studies using concentric ring bifocal and peripheral add multifocal contact lenses to slow myopia progression in school-aged children: a meta-analysis. Ophthalmic Physiol Opt. 2017;37:51–9.CrossRefPubMed Li SM, Kang MT, Wu SS, Meng B, Sun YY, Wei SF, et al. Studies using concentric ring bifocal and peripheral add multifocal contact lenses to slow myopia progression in school-aged children: a meta-analysis. Ophthalmic Physiol Opt. 2017;37:51–9.CrossRefPubMed
7.
go back to reference Song YY, Wang H, Wang BS, Qi H, Rong ZX, Chen HZ. Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials. J Ocular Pharmacol. 2011;27:361–8.CrossRef Song YY, Wang H, Wang BS, Qi H, Rong ZX, Chen HZ. Atropine in ameliorating the progression of myopia in children with mild to moderate myopia: a meta-analysis of controlled clinical trials. J Ocular Pharmacol. 2011;27:361–8.CrossRef
8.
go back to reference Huang J, Wen D, Wang Q, McAlinden C, Flitcroft I, Chen H, et al. Efficacy comparison of 16 interventions for myopia control in children: a network meta-analysis. Ophthalmology. 2016;123:697–708.CrossRefPubMed Huang J, Wen D, Wang Q, McAlinden C, Flitcroft I, Chen H, et al. Efficacy comparison of 16 interventions for myopia control in children: a network meta-analysis. Ophthalmology. 2016;123:697–708.CrossRefPubMed
9.
go back to reference Si JK, Tang K, Bi HS, Guo DD, Guo JG, Wang XR. Orthokeratology for myopia control: a meta-analysis. Optom Vis Sci. 2015;92:252–7.CrossRefPubMed Si JK, Tang K, Bi HS, Guo DD, Guo JG, Wang XR. Orthokeratology for myopia control: a meta-analysis. Optom Vis Sci. 2015;92:252–7.CrossRefPubMed
10.
go back to reference He M, Du Y, Liu Q, Ren C, Liu J, Wang Q, et al. Effects of orthokeratology on the progression of low to moderate myopia in Chinese children. BMC ophthalmol. 2016;16:126.CrossRefPubMedPubMedCentral He M, Du Y, Liu Q, Ren C, Liu J, Wang Q, et al. Effects of orthokeratology on the progression of low to moderate myopia in Chinese children. BMC ophthalmol. 2016;16:126.CrossRefPubMedPubMedCentral
11.
12.
go back to reference Swarbrick HA, Alharbi A, Watt K, Lum E, Kang P. Myopia control during orthokeratology lens wear in children using a novel study design. Ophthalmology. 2015;122:620–30.CrossRefPubMed Swarbrick HA, Alharbi A, Watt K, Lum E, Kang P. Myopia control during orthokeratology lens wear in children using a novel study design. Ophthalmology. 2015;122:620–30.CrossRefPubMed
13.
go back to reference Cheung SW, Cho P, Fan D. Asymmetrical increase in axial length in the two eyes of a monocular orthokeratology patient. Vision Res. 2004;81:653–6. Cheung SW, Cho P, Fan D. Asymmetrical increase in axial length in the two eyes of a monocular orthokeratology patient. Vision Res. 2004;81:653–6.
14.
go back to reference Hashemi H, Khabazkhoob M, Emamian MH, Shariati M, Abdolahi-nia T, Fotouhi A. All biometric components are important in anisometropia, not just axial length. Br J Ophthalmol. 2013;97:1586–91.CrossRefPubMed Hashemi H, Khabazkhoob M, Emamian MH, Shariati M, Abdolahi-nia T, Fotouhi A. All biometric components are important in anisometropia, not just axial length. Br J Ophthalmol. 2013;97:1586–91.CrossRefPubMed
15.
go back to reference Zeng J, Cui Y, Li J, Xie W, Li Z, Zhang L, et al. Correlation of axial length and corneal curvature with diopter in eyes of adults with anisometropia. Int J Clin Exp Med. 2015;8:13639–43.PubMedPubMedCentral Zeng J, Cui Y, Li J, Xie W, Li Z, Zhang L, et al. Correlation of axial length and corneal curvature with diopter in eyes of adults with anisometropia. Int J Clin Exp Med. 2015;8:13639–43.PubMedPubMedCentral
16.
go back to reference Smith EL 3rd, Hung LF, Huang J. Relative peripheral hyperopic defocus alters central refractive development in infant monkeys. Vision Res. 2009;49:2386–92.CrossRefPubMedPubMedCentral Smith EL 3rd, Hung LF, Huang J. Relative peripheral hyperopic defocus alters central refractive development in infant monkeys. Vision Res. 2009;49:2386–92.CrossRefPubMedPubMedCentral
17.
go back to reference Liu Y, Wildsoet C. The effect of two-zone concentric bifocal spectacle lenses on refractive error development and eye growth in young chicks. Invest Ophthalmol Vis Sci. 2011;52:1078–86.CrossRefPubMedPubMedCentral Liu Y, Wildsoet C. The effect of two-zone concentric bifocal spectacle lenses on refractive error development and eye growth in young chicks. Invest Ophthalmol Vis Sci. 2011;52:1078–86.CrossRefPubMedPubMedCentral
18.
go back to reference Zhu MJ, Feng HY, He XG, Zou HD, Zhu JF. The control effect of orthokeratology on axial length elongation in Chinese children with myopia. BMC ophthalmol. 2014;14:141.CrossRefPubMedPubMedCentral Zhu MJ, Feng HY, He XG, Zou HD, Zhu JF. The control effect of orthokeratology on axial length elongation in Chinese children with myopia. BMC ophthalmol. 2014;14:141.CrossRefPubMedPubMedCentral
19.
go back to reference Paune J, Morales H, Armengol J, Quevedo L, Faria-Ribeiro M, Gonzalez-Meijome JM. Myopia control with a novel peripheral gradient soft lens and orthokeratology: a 2-year clinical trial. Biomed Res Int. 2015;2015:507572.CrossRefPubMedPubMedCentral Paune J, Morales H, Armengol J, Quevedo L, Faria-Ribeiro M, Gonzalez-Meijome JM. Myopia control with a novel peripheral gradient soft lens and orthokeratology: a 2-year clinical trial. Biomed Res Int. 2015;2015:507572.CrossRefPubMedPubMedCentral
20.
go back to reference Chan KY, Cheung SW, Cho P. Orthokeratology for slowing myopic progression in a pair of identical twins. Cont Lens Anterior Eye. 2014;37:116–9.CrossRefPubMed Chan KY, Cheung SW, Cho P. Orthokeratology for slowing myopic progression in a pair of identical twins. Cont Lens Anterior Eye. 2014;37:116–9.CrossRefPubMed
21.
go back to reference Deng L, Gwiazda J, Manny RE, Scheiman M, Weissberg E, Fern KD, et al. Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci. 2014;55:2097–105.CrossRefPubMedPubMedCentral Deng L, Gwiazda J, Manny RE, Scheiman M, Weissberg E, Fern KD, et al. Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci. 2014;55:2097–105.CrossRefPubMedPubMedCentral
22.
go back to reference Kang P, Swarbrick H. Peripheral refraction in myopic children wearing orthokeratology and gas-permeable lenses. Optom Vis Sci. 2011;88:476–82.CrossRefPubMed Kang P, Swarbrick H. Peripheral refraction in myopic children wearing orthokeratology and gas-permeable lenses. Optom Vis Sci. 2011;88:476–82.CrossRefPubMed
23.
go back to reference Lyu Byul, Hwang Kyu Yeon, Kim Sun Young, Kim Su Young, Na Kyung Sun. Effectiveness of toric orthokeratology in the treatment of patients with combined myopia and astigmatism. Korean J Ophthalmol. 2016;30:434–42.CrossRefPubMedPubMedCentral Lyu Byul, Hwang Kyu Yeon, Kim Sun Young, Kim Su Young, Na Kyung Sun. Effectiveness of toric orthokeratology in the treatment of patients with combined myopia and astigmatism. Korean J Ophthalmol. 2016;30:434–42.CrossRefPubMedPubMedCentral
24.
go back to reference Chen Z, Xue F, Zhou J, Qu X, Zhou X. Effects of orthokeratology on choroidal thickness and axial length. Optom Vis Sci. 2016;93:1064–71.CrossRefPubMed Chen Z, Xue F, Zhou J, Qu X, Zhou X. Effects of orthokeratology on choroidal thickness and axial length. Optom Vis Sci. 2016;93:1064–71.CrossRefPubMed
Metadata
Title
The effect of orthokeratology on axial length elongation in children with myopia: Contralateral comparison study
Authors
Miri Na
Aeri Yoo
Publication date
01-05-2018
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 3/2018
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-018-0573-x

Other articles of this Issue 3/2018

Japanese Journal of Ophthalmology 3/2018 Go to the issue