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European Surgery

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01-05-2016 | ICS congress 2015

Resectability of rectal cancer after neoadjuvant treatment – current status

Authors: M. Sabol, MD PhD, R. Donát, P. Chvalný, J. Palaj, D. Dyttert, P. Mračna, Š. Durdík

Published in: European Surgery | Special Issue 2/2016

Abstract

Background

The purpose of the study was to compare our experience to recent trends of multimodal treatment of patients with locally advanced rectal cancer.

Patients and methods

209 patients with histologically proven adenocarcinoma of the rectum were treated for 3 years by a multimodal approach in a single center. Patients were evaluated for clinical and pathologic response. The type of surgical procedure and the number of retrieved lymph nodes and postoperative complications were recorded.

Results

Neoadjuvant Chemoradiotherapy (CRT) had a downstaging effect in more than half of our patients (50.61 %), and about one quarter of them achieved a complete pathologic response (22.22 %).

Conclusions

Preoperative CRT produced an encouraging down-staging effect with acceptable toxicity and perioperative complications.

Ferenschild FT, Dawson I, de Graaf EJ, de Wilt JH, Tetteroo GW. Preoperative radiotherapy has no value for patients with T2–3, N0 adenocarcinomas of the rectum. Dig Surg. 2009;26(4):291–296. doi:10.1159/000227771..CrossRefPubMed

Rödel C, Trojan J, Bechstein WO, Woeste G. Neoadjuvant short- or long-term radio(chemo)therapy for rectal cancer: how and who should be treated? Dig Dis. 2012;30(2):102–108. doi:10.1159/000342038.CrossRefPubMed

Van Gijn, et al. Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol. 2011;12:575–582.CrossRefPubMed

Valentini V. Tumor regression grading in rectal cancer: is it time to move forward? J Clin Oncol. 2014;32(15):1534–1536.CrossRefPubMed

Kulu Y, Ulrich A, Buchler MW. Resectable rectal cancer: Which patient does not need preoperative radiotherapy? Dig Dis. 2012;30(2):118–125.CrossRefPubMed

Title: Resectability of rectal cancer after neoadjuvant treatment – current status
Authors: M. Sabol, MD PhD
R. Donát
P. Chvalný
J. Palaj
D. Dyttert
P. Mračna
Š. Durdík
Publication date: 01-05-2016
Publisher: Springer Vienna
Published in: European Surgery / Issue Special Issue 2/2016
Print ISSN: 1682-8631
Electronic ISSN: 1682-4016
DOI: https://doi.org/10.1007/s10353-016-0404-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Resectability of rectal cancer after neoadjuvant treatment – current status

Abstract

Background

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusions

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