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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-06-2020 | Magnetic Resonance Imaging | Research Article

Quantification of sodium T1 in abdominal tissues at 3 T

Authors: Ryszard Stefan Gomolka, Alexander Ciritsis, Andreas Meier, Cristina Rossi

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2020

Abstract

Introduction

Although relevant for assessment of sodium in multiple endocrine pathways, ²³Na-T1 quantification is challenging due to technical limitations (SAR, B1 inhomogeneity) or influence of tissue’s local molecular dynamics. Hereby, we propose T1 quantification of ²³Na-MRI signal acquired over the abdomen using a centric-reordered saturation-recovery (SR) true fast imaging with steady state precession (TrueFISP) sequence.

Materials and methods

Measurements were performed at 3T using a dual-tunable ²³Na/¹H coil in 7 healthy volunteers (TR/TE = 858–928/1.57 ms; flip angle = 90°; bandwidth = 450 Hz/px; voxel size = 5 × 5 × 10 mm³). Variable T1-weighting was achieved applying non-selective saturation pre-pulses delayed from the centre of the k-space acquisition by 25, 40, 60, 120 and 250 ms. T1-curve fitting was performed slice-wise, separately for average intensity values from the manually segmented areas of the renal parenchyma and spinal canal, over the increasing SR times- assuming monoexponential signal pattern.

Results

Mean ± standard deviation of ²³Na-T1 was found as 29 ± 10 ms and 35 ± 8 ms for the renal parenchyma and the spinal canal, respectively.

Discussion

²³Na-T1 quantification using a SR-TrueFISP is feasible in clinical settings, in the images constrained by clinically applicable acquisition time of reduced spatial resolution or averages.

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Title: Quantification of sodium T1 in abdominal tissues at 3 T
Authors: Ryszard Stefan Gomolka
Alexander Ciritsis
Andreas Meier
Cristina Rossi
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00786-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Quantification of sodium T1 in abdominal tissues at 3 T

Abstract

Introduction

Materials and methods

Results

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and methods

Results

Discussion

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