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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-06-2020 | Magnetic Resonance Imaging | Research Article

Intravascular signal suppression and microvascular signal mapping using delays alternating with nutation for tailored excitation (DANTE) pulse for arterial spin labeling perfusion imaging

Authors: Yasuhiro Fujiwara, Hirohiko Kimura, Shota Ishida, Masayuki Kanamoto, Naoyuki Takei, Tsuyoshi Matsuda, Nobuyuki Kosaka, Toshiki Adachi

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2020

Abstract

Objective

To optimize the delays alternating with nutation for tailored excitation (DANTE) pulse as a vascular crushing gradient to eliminate macro-and micro-vascular signals and to generate a macrovascular space-related map by applying DANTE with multiple conditions.

Materials and methods

Numerical simulation was performed to estimate the optimal flip angle (FA) of the DANTE. A phantom study was conducted to evaluate the impact of the FA and gradient area (GA) of the DANTE with three flow velocities and various parameters of the DANTE. Finally, an in vivo study was performed to assess the optimal DANTE parameters and to map the estimated macrovascular signal of the arterial spin labeling (ASL) signal.

Results

Numerical simulation revealed that the decrease of magnetization plateaued at 12.5° of FA. The phantom study showed that the setting of larger FA or GA decreased the ASL signals. The decrease of the ASL signal depended on the flow velocity, and the dependence increased with decreasing GA. The in vivo study revealed that larger FA and GA decreased the perfusion signal.

Discussion

An optimized DANTE makes it possible to efficiently suppress the macro-and-micro vascular signals depending on the flow velocity. Moreover, macrovascular signal mapping may be useful to assess altered hemodynamic states.

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Title: Intravascular signal suppression and microvascular signal mapping using delays alternating with nutation for tailored excitation (DANTE) pulse for arterial spin labeling perfusion imaging
Authors: Yasuhiro Fujiwara
Hirohiko Kimura
Shota Ishida
Masayuki Kanamoto
Naoyuki Takei
Tsuyoshi Matsuda
Nobuyuki Kosaka
Toshiki Adachi
Publication date: 01-06-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00785-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intravascular signal suppression and microvascular signal mapping using delays alternating with nutation for tailored excitation (DANTE) pulse for arterial spin labeling perfusion imaging

Abstract

Objective

Materials and methods

Results

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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