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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-04-2020 | Tetralogy of Fallot | Research Article

Severe pulmonary regurgitation in adolescents with tetralogy of Fallot leads to increased longitudinal strain

Authors: Pekka Ylitalo, Lauri Lehmonen, Kirsi Lauerma, Miia Holmström, Olli Pitkänen-Argillander, Eero Jokinen

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2020

Abstract

Objectives

Postoperative patients with tetralogy of Fallot (TOF) are often compromised by chronic pulmonary regurgitation and chronic right ventricular volume load. We sought to determine whether pulmonary regurgitation (PR) would affect right and left ventricle (RV and LV) strain.

Materials and methods

This cross-sectional analysis included 40 patients who had TOF with surgical repair, with an average follow-up period of 11.8 ± 3.0 years. Altogether, 44 healthy volunteers with similar age and gender distribution were recruited. A cardiovascular magnetic resonance imaging study with feature tracking analysis was performed on all patients and controls.

Results

RV peak longitudinal strain was increased in TOF patients with PR > 30 ml/m² when compared to those with PR < 30 ml/m² (− 22.5% ± 2.7% vs − 19.7% ± 3.5%, p = 0.018) and controls (p = 0.007). PR volume correlated with peak RV longitudinal strain (R = − 0.37, p = 0.030) and peak RV longitudinal strain rate (systolic: R = 0.37, p = 0.03; diastolic: R = 0.39, p = 0.021). The peak RV circumferential strain, from base to apex, increased more than in healthy controls (apex-base difference 7.6% ± 4.2% vs 3.3% ± 2.4%, p < 0.0001).

Conclusions

Pediatric patients with TOF and a severe pulmonary regurgitation show an enhanced longitudinal strain when compared to patients with milder regurgitation or to control subjects. In addition, mean RV circumferential strain of the patients is significantly enhanced compared to healthy individuals.

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Title: Severe pulmonary regurgitation in adolescents with tetralogy of Fallot leads to increased longitudinal strain
Authors: Pekka Ylitalo
Lauri Lehmonen
Kirsi Lauerma
Miia Holmström
Olli Pitkänen-Argillander
Eero Jokinen
Publication date: 01-04-2020
Publisher: Springer International Publishing
Keywords: Tetralogy of Fallot
Tetralogy of Fallot
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00780-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Severe pulmonary regurgitation in adolescents with tetralogy of Fallot leads to increased longitudinal strain

Abstract

Objectives

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

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