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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-02-2018 | Research Article

Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T ₁ mapping: averaging to improve precision and correlation with collagen volume fraction

Authors: Vassilios S. Vassiliou, Katharina Wassilew, Donnie Cameron, Ee Ling Heng, Evangelia Nyktari, George Asimakopoulos, Anthony de Souza, Shivraman Giri, Iain Pierce, Andrew Jabbour, David Firmin, Michael Frenneaux, Peter Gatehouse, Dudley J. Pennell, Sanjay K. Prasad

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2018

Abstract

Objectives

Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T ₁ mapping versus assessment at a single ventricular level.

Materials and methods

For assessment of T ₁ mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T ₁ and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T ₁, allowing calculation of partition coefficient and ECV. To assess correlation of T ₁ mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction.

Results

A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T ₁ maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R ² = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T ₁ mapping.

Conclusion

T ₁ mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T ₁/ECV might affect clinical management.

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Title: Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction
Authors: Vassilios S. Vassiliou
Katharina Wassilew
Donnie Cameron
Ee Ling Heng
Evangelia Nyktari
George Asimakopoulos
Anthony de Souza
Shivraman Giri
Iain Pierce
Andrew Jabbour
David Firmin
Michael Frenneaux
Peter Gatehouse
Dudley J. Pennell
Sanjay K. Prasad
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2018
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-017-0630-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T ₁ mapping: averaging to improve precision and correlation with collagen volume fraction

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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