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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-02-2018 | Research Article

Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study

Authors: Jianmin Yuan, Gregory Makris, Andrew Patterson, Ammara Usman, Tilak Das, Andrew Priest, Zhongzhao Teng, Sarah Hilborne, Dario Prudencio, Jonathan Gillard, Martin Graves

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2018

Abstract

Objective

This study aims to explore the relationship between plaque surface morphology and neovascularization using a high temporal and spatial resolution 4D contrast-enhanced MRI/MRA sequence.

Materials and methods

Twenty one patients with either recent symptoms or a carotid artery stenosis ≥40% were recruited in this study. Plaque surface morphology and luminal stenosis were determined from the arterial phase MRA images. Carotid neovascularization was evaluated by a previously validated pharmacokinetic (PK) modeling approach. K ^trans (transfer constant) and v _p (partial plasma volume) were calculated in both the adventitia and plaque.

Results

Image acquisition and analysis was successfully performed in 28 arteries. Mean luminal stenosis was 44% (range 11–82%). Both adventitial and plaque K ^trans in ulcerated/irregular plaques were significantly higher than smooth plaques (0.079 ± 0.018 vs. 0.064 ± 0.011 min⁻¹, p = 0.02; 0.065 ± 0.013 vs. 0.055 ± 0.010 min⁻¹, p = 0.03, respectively). Positive correlations between adventitial K ^trans and v _p against stenosis were observed (r = 0.44, p = 0.02; r = 0.55, p = 0.01, respectively).

Conclusion

This study demonstrates the feasibility of using a single sequence to acquire both high resolution 4D CE-MRA and DCE-MRI to evaluate both plaque surface morphology and function. The results demonstrate significant relationships between lumen surface morphology and neovascularization.

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Title: Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study
Authors: Jianmin Yuan
Gregory Makris
Andrew Patterson
Ammara Usman
Tilak Das
Andrew Priest
Zhongzhao Teng
Sarah Hilborne
Dario Prudencio
Jonathan Gillard
Martin Graves
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2018
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-017-0621-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study

Abstract

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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