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Magnetic Resonance Materials in Physics, Biology and Medicine

Published in:

01-08-2015 | Short Communication

Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength

Authors: Gregory Chang, Alexandra Hotca-Cho, Henry Rusinek, Stephen Honig, Artem Mikheev, Kenneth Egol, Ravinder R. Regatte, Chamith S. Rajapakse

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 4/2015

Abstract

Introduction

Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.

Methods

This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.

Results

Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.

Conclusion

The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.

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Title: Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength
Authors: Gregory Chang
Alexandra Hotca-Cho
Henry Rusinek
Stephen Honig
Artem Mikheev
Kenneth Egol
Ravinder R. Regatte
Chamith S. Rajapakse
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 4/2015
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-014-0475-y

At a glance: The STEP trials

Springer Medicine

Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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