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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 6/2008

01-06-2008 | Short Communication

MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data

Authors: Thomas Beyer, Markus Weigert, Harald H. Quick, Uwe Pietrzyk, Florian Vogt, Christoph Palm, Gerald Antoch, Stefan P. Müller, Andreas Bockisch

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2008

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Abstract

Purpose

MR-based attenuation correction (AC) will become an integral part of combined PET/MR systems. Here, we propose a toolbox to validate MR-AC of clinical PET/MRI data sets.

Methods

Torso scans of ten patients were acquired on a combined PET/CT and on a 1.5-T MRI system. MR-based attenuation data were derived from the CT following MR–CT image co-registration and subsequent histogram matching. PET images were reconstructed after CT- (PETCT) and MR-based AC (PETMRI). Lesion-to-background (L/B) ratios were estimated on PETCT and PETMRI.

Results

MR–CT histogram matching leads to a mean voxel intensity difference in the CT- and MR-based attenuation images of 12% (max). Mean differences between PETMRI and PETCT were 19% (max). L/B ratios were similar except for the lung where local misregistration and intensity transformation leads to a biased PETMRI.

Conclusion

Our toolbox can be used to study pitfalls in MR-AC. We found that co-registration accuracy and pixel value transformation determine the accuracy of PETMRI.
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Metadata
Title
MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data
Authors
Thomas Beyer
Markus Weigert
Harald H. Quick
Uwe Pietrzyk
Florian Vogt
Christoph Palm
Gerald Antoch
Stefan P. Müller
Andreas Bockisch
Publication date
01-06-2008
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-0734-0

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