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Magnetic Resonance Materials in Physics, Biology and Medicine

Published in:

01-10-2012 | Research Article

Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer’s disease

Authors: Mohammed A. Warsi, William Molloy, Michael D. Noseworthy

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2012

Abstract

Objectives

To correlate temporal fractal structure of resting state blood oxygen level dependent (rsBOLD) functional magnetic resonance imaging (fMRI) with in vivo proton magnetic resonance spectroscopy (¹H-MRS), in Alzheimer’s disease (AD) and healthy age-matched normal controls (NC).

Materials and methods

High temporal resolution (4 Hz) rsBOLD signal and single voxel (left putamen) magnetic resonance spectroscopy data was acquired in 33 AD patients and 13 NC. The rsBOLD data was analyzed using two types of fractal dimension (FD) analysis based on relative dispersion and frequency power spectrum. Comparisons in FD were performed between AD and NC, and FD measures were correlated with ¹H-MRS findings.

Results

Temporal fractal analysis of rsBOLD, was able to differentiate AD from NC subjects (P = 0.03). Low FD correlated with markers of AD severity including decreased concentrations of N-acetyl aspartate (R = 0.44, P = 0.015) and increased myoinositol (mI) (R = −0.45, P = 0.012).

Conclusion

Based on these results we suggest fractal analysis of rsBOLD could provide an early marker of AD.

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Title: Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer’s disease
Authors: Mohammed A. Warsi
William Molloy
Michael D. Noseworthy
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2012
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-012-0312-0

At a glance: The STEP trials

Springer Medicine

Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer’s disease

Abstract

Objectives

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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